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Podxl Gene Detail
Summary
  • Symbol
    Podxl
  • Name
    podocalyxin-like
  • Synonyms
    Ly102, PC, Pclp1, podocalyxin, Podxl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351317
    NCBI Gene: 27205
  • Gene Overview
    MyGene.info: PODXL
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:31519493-31563937 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351317
protein coding gene Chr6:31519488-31563981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030549
protein coding gene Chr6:29455460-29500997 (-)
A/J MGP_AJ_G0030522
protein coding gene Chr6:28202179-28252316 (-)
AKR/J MGP_AKRJ_G0030449
protein coding gene Chr6:29139578-29190227 (-)
BALB/cJ MGP_BALBcJ_G0030532
protein coding gene Chr6:28324235-28369040 (-)
C3H/HeJ MGP_C3HHeJ_G0030245
protein coding gene Chr6:29151557-29197108 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030986
protein coding gene Chr6:30271037-30322732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028197
protein coding gene Chr6:26367237-26411858 (-)
CAST/EiJ MGP_CASTEiJ_G0029647
protein coding gene Chr6:28938588-28983291 (-)
CBA/J MGP_CBAJ_G0030223
protein coding gene Chr6:31440813-31489300 (-)
DBA/2J MGP_DBA2J_G0030367
protein coding gene Chr6:28107015-28155474 (-)
FVB/NJ MGP_FVBNJ_G0030321
protein coding gene Chr6:27896189-27941786 (-)
LP/J MGP_LPJ_G0030454
protein coding gene Chr6:29630832-29681723 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030357
protein coding gene Chr6:33834248-33885488 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031016
protein coding gene Chr6:29037334-29085141 (-)
PWK/PhJ MGP_PWKPhJ_G0029361
protein coding gene Chr6:27690873-27736867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029197
protein coding gene Chr6:28734180-28779389 (-)
WSB/EiJ MGP_WSBEiJ_G0029723
protein coding gene Chr6:28957899-29005868 (-)



Homology
more
  • Human Ortholog
    PODXL, podocalyxin like
  • Vertebrate Orthologs
    2
  • Human Ortholog
    PODXL, podocalyxin like
    Orthology source: HGNC
  • Synonyms
    Gp200, PC, PCLP, PCLP-1
  • Links
    NCBI Gene ID: 5420
    neXtProt AC: NX_O00592
    UniProt: O00592

  • Chr Location
    7q32.3; chr7:131500262-131556617 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality and severe kidney defects including absence of the podocyte slit diaphragm and foot processes and anuria. While a subset display edema and/or omphalocele, most mice appear normal at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27205 NCBI Gene Model | MGI Sequence Detail 44445 C57BL/6J ±  kb
    transcript NM_013723 RefSeq | MGI Sequence Detail 5330 C57BL/6  
    polypeptide Q9R0M4 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 104
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141647
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 49
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:58693 Hara T, et al., Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region. Immunity. 1999 Nov;11(5):567-78
    • Latest
      J:260459 Azizoglu DB, et al., Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory