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Podxl
Gene Detail
Symbol

Name
ID
Podxl
podocalyxin-like
MGI:1351317
Synonyms
Ly102, PC, Pclp1, podocalyxin
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:31519488-31563981 bp, - strand
From VEGA annotation of GRCm38

  44494 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137260  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: PODXL
Protein SuperFamily: podocalyxin-like protein 1
Gene Tree: Podxl

Human
homologs
PODXL, podocalyxin-like
Orthology source: HGNC

IDs:
NCBI Gene ID: 5420
neXtProt AC: NX_O00592

Human Synonyms: Gp200, PC, PCLP, PCLP-1

Human Chr (Location): 7q32-q33; chr7:131500262-131556617 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit complete neonatal lethality and anuric renal failure associated with podocyte structural malformations. A subset of homozygotes display hydrops fetalis and omphalocele.
 
Phenotype Images(3)
Interactions
Podxl interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, cell migration, ...
Component apical plasma membrane, cell body, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (532)    Tissues (263)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 518
Northern blot 12
cDNA source data(103)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PODXL ZFIN podxl    NEW 
Molecular
reagents
All nucleic(106) cDNA(103) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000014732 (Evidence)
Ensembl Gene Model ENSMUSG00000025608 (Evidence)
Entrez Gene 27205 (Evidence)
UniGene 89918
DFCI TC1583287, TC1694019, TC1651792, TC1608237
DoTS DT.490377, DT.94344845
NIA Mouse Gene Index U027136
Consensus CDS Project CCDS19983.1
International Mouse Phenotyping Consortium Status Podxl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014732 VEGA Gene Model | MGI Sequence Detail 44494 C57BL/6J ±  kb
transcript OTTMUST00000034974 VEGA | MGI Sequence Detail 5379 Not Applicable 
polypeptide OTTMUSP00000015620 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013836 CD34/Podocalyxin
InterPro IPR017403 Podocalyxin-like protein 1
Protein Ontology PR:000012955 podocalyxin-like protein 1
References
(Earliest) J:58693 Hara T, et al., Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region. Immunity. 1999 Nov;11(5):567-78
(Latest) J:206768 Zhang H, et al., Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm. Stem Cells. 2014 Jan;32(1):191-203
All references(65)
Other
accession IDs
MGI:2141647

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory