Tlx3
Gene Detail

Symbol Name ID

Tlx3 T cell leukemia, homeobox 3 MGI:1351209

Synonyms

Hox11l2, Rnx, Tlx1l2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

19.21 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:33200752-33203588 bp, - strand From VEGA annotation of GRCm38   2837 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23181  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tlx3

Human homologs

Human Homolog		TLX3, T-cell leukemia homeobox 3
NCBI Gene ID		30012
neXtProt AC		NX_O43711
Human Synonyms		HOX11L2, RNX
Human Chr (Location)		5q35.1; chr5:170736288-170739138 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome.

 
Human Diseases Modeled Using Mouse Tlx3 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell fate specification, central nervous system development, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (46 records)
Data Summary: Results (116)    Tissues (91)    Images (14)
Theiler Stages: 15, 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	116

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(3) cDNA(11) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005392 (Evidence)
Ensembl Gene Model	ENSMUSG00000040610 (Evidence)
Entrez Gene	27140 (Evidence)
UniGene	25362
DFCI	TC1600761
DoTS	DT.527379
NIA Mouse Gene Index	U032642
Consensus CDS Project	CCDS24533.1
International Mouse Knockout Project Status	Tlx3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005392	VEGA Gene Model | MGI Sequence Detail	2837	C57BL/6J
transcript	OTTMUST00000012022	VEGA | MGI Sequence Detail	1532	Not Applicable
polypeptide	OTTMUSP00000005571	VEGA | MGI Sequence Detail	291	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000016385	T-cell leukemia homeobox protein 3

References

(Earliest) J:11834 Dear TN, et al., The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4431-5
(Latest) J:186470 Lopes C, et al., Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012 Jul 11;32(28):9706-15
All references(77)