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Tlx3
Gene Detail
Symbol

Name
ID
Tlx3
T cell leukemia, homeobox 3
MGI:1351209
Synonyms
Hox11l2, Rnx, Tlx1l2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.21 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:33200752-33203589 bp, - strand
From VEGA annotation of GRCm38

  2838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23181  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Tlx3

Human
homologs
Human Homolog TLX3, T-cell leukemia homeobox 3
NCBI Gene ID 30012
neXtProt AC  NX_O43711
Human Synonyms  HOX11L2, RNX
Human Chr (Location)  5q35.1; chr5:171309284-171312134 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements.
 
Human Diseases Modeled Using Mouse Tlx3 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Tlx3 interacts with 91 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell fate specification, central nervous system development, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (134)    Tissues (105)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 120
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(3) cDNA(11) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005392 (Evidence)
Ensembl Gene ModelENSMUSG00000040610 (Evidence)
Entrez Gene27140 (Evidence)
UniGene25362
DFCITC1600761
DoTSDT.527379
NIA Mouse Gene IndexU032642
Consensus CDS ProjectCCDS24533.1
International Mouse Knockout Project StatusTlx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005392 VEGA Gene Model | MGI Sequence Detail 2838 C57BL/6J ±  kb
transcript OTTMUST00000012022 VEGA | MGI Sequence Detail 1533 Not Applicable 
polypeptide OTTMUSP00000005571 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016385 T-cell leukemia homeobox protein 3
References
(Earliest) J:11834 Dear TN, et al., The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4431-5
(Latest) J:206629 Marklund U, et al., Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem Cells Dev. 2014 Jan 1;23(1):5-15
All references(87)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory