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Tlx3 Gene Detail
Summary
  • Symbol
    Tlx3
  • Name
    T cell leukemia, homeobox 3
  • Synonyms
    Hox11l2, Rnx, Tlx1l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351209
    NCBI Gene: 27140
  • Gene Overview
    MyGene.info: TLX3
Location & Maps
more
  • Sequence Map
    Chr11:33200752-33203589 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2838 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.21 cM, cytoband A5
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TLX3, T-cell leukemia homeobox 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TLX3, T-cell leukemia homeobox 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HOX11L2, RNX
  • Links
    NCBI Gene ID: 30012
    neXtProt AC: NX_O43711

  • Chr Location
    5q35.1; chr5:171309284-171312134 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tlx3 mouse models

Human Disease Mouse Models
       Central Hypoventilation Syndrome, Congenital; CCHS   OMIM: 209880 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Tlx3
  • Incidental Mutations
Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005392 VEGA Gene Model | MGI Sequence Detail 2838 C57BL/6J ±  kb
transcript OTTMUST00000012022 VEGA | MGI Sequence Detail 1533 Not Applicable  
polypeptide OTTMUSP00000005571 VEGA | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 3
    cDNA 11
    Other 3

    Microarray probesets 3
References
more
  • Summaries
    All 87
    Developmental Gene Expression 58
    Diseases 2
    Gene Ontology 10
    Phenotypes 21
  • Earliest
    J:11834 Dear TN, et al., The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4431-5
  • Latest
    J:231591 Iskusnykh IY, et al., Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory