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Tlx3
Gene Detail
Symbol

Name
ID
Tlx3
T cell leukemia, homeobox 3
MGI:1351209
Synonyms
Hox11l2, Rnx, Tlx1l2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.21 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:33200752-33203589 bp, - strand
From VEGA annotation of GRCm38

  2838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23181  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TLX3
Gene Tree: Tlx3

Human
homologs
TLX3, T-cell leukemia homeobox 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 30012
neXtProt AC: NX_O43711

Human Synonyms: HOX11L2, RNX

Human Chr (Location): 5q35.1; chr5:171309284-171312134 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements.
 
Human Diseases Modeled in Mice Using Tlx3 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Tlx3 interacts with 91 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell fate specification, central nervous system development, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (56 records)
Data Summary: Results (134)    Tissues (105)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 120
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tlx3 ; ZFIN tlx3b    NEW 
Molecular
reagents
All nucleic(16) Genomic(3) cDNA(11) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005392 (Evidence)
Ensembl Gene Model ENSMUSG00000040610 (Evidence)
Entrez Gene 27140 (Evidence)
UniGene 25362
DFCI TC1600761
DoTS DT.527379
NIA Mouse Gene Index U032642
Consensus CDS Project CCDS24533.1
International Mouse Phenotyping Consortium Status Tlx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005392 VEGA Gene Model | MGI Sequence Detail 2838 C57BL/6J ±  kb
transcript OTTMUST00000012022 VEGA | MGI Sequence Detail 1533 Not Applicable 
polypeptide OTTMUSP00000005571 VEGA | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016385 T-cell leukemia homeobox protein 3
References
(Earliest) J:11834 Dear TN, et al., The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4431-5
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(87)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory