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Cadps
Gene Detail
 Symbol
Name
ID
Cadps
Ca2+-dependent secretion activator
MGI:1350922
Synonyms CAPS1, mKIAA1121
Feature Type protein coding gene
Genetic Map
Chromosome 14
6.37 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:12372563-12823079 bp, - strand
From NCBI annotation of GRCm38

  450517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cadps

Human
homologs
Human Homolog CADPS, Ca++-dependent secretion activator
NCBI Gene ID 8618
neXtProt AC  NX_Q9ULU8
Human Synonyms  CADPS1, CAPS, CAPS1
Human Chr (Location)  3p14.2; chr3:62398346-62875389 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality, respiratory failure and abnormal adrenal gland physiology. Adult heterozygous null mice display abnormal adrenal gland physiology that is different from that seen in homozygous neonates.
 
Interactions
Cadps interacts with 287 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process catecholamine secretion, positive regulation of calcium ion-dependent exocytosis, ...
Component cell, cell junction, ...
Function calcium ion binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (329)    Tissues (122)    Images (77)
Theiler Stages: 19, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 114
RNA in situ 202
Western blot 13
cDNA source data(63)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) cDNA(64) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054423 (Evidence)
Entrez Gene27062 (Evidence)
UniGene260881
DFCITC1580076, TC1601483, TC1601834
DoTSDT.101333074, DT.101381380, DT.40185468, DT.91370728, DT.94293365, DT.99838872
NIA Mouse Gene IndexU035240
Consensus CDS ProjectCCDS36806.1, CCDS36807.1
International Mouse Knockout Project StatusCadps
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27062 NCBI Gene Model | MGI Sequence Detail 450517 C57BL/6J ±  kb
transcript NM_012061 RefSeq | MGI Sequence Detail 5478 C57BL/6 
polypeptide Q80TJ1 UniProt | EBI | MGI Sequence Detail 1355 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(55) UniProt(3)
Polymorphisms SNPs within 2kb(4132 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4134)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR010439 Calcium-dependent secretion activator
InterPro IPR014770 Munc13 homology 1
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000004964 calcium-dependent secretion activator 1
Graphical View of Protein Domain Structure
References (Earliest) J:80393 Cisternas FA, et al., Cloning and characterization of human CADPS and CADPS2, new members of the Ca(2+)-dependent activator for secretion protein family. Genomics. 2003 Mar;81(3):279-91
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(48)
Other
accession IDs
MGI:2145766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory