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Cadps
Gene Detail
Symbol

Name
ID
Cadps
Ca2+-dependent secretion activator
MGI:1350922
Synonyms
CAPS1, mKIAA1121
Feature Type
protein coding gene
Genetic Map
Chromosome 14
6.37 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:12372563-12823079 bp, - strand
From Ensembl annotation of GRCm38

  450517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CADPS
Gene Tree: Cadps

Human
homologs
CADPS, Ca++-dependent secretion activator
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8618
neXtProt AC: NX_Q9ULU8

Human Synonyms: CADPS1, CAPS, CAPS1

Human Chr (Location): 3p14.2; chr3:62398346-62875389 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display neonatal lethality, respiratory failure and abnormal adrenal gland physiology. Adult heterozygous null mice display abnormal adrenal gland physiology that is different from that seen in homozygous neonates.
 
Interactions
Cadps interacts with 286 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process catecholamine secretion, positive regulation of calcium ion-dependent exocytosis, ...
Component cell, cell junction, ...
Function calcium ion binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (335)    Tissues (124)    Images (80)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 114
RNA in situ 202
Western blot 13
RT-PCR 6
cDNA source data(63)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cadps    NEW 
Molecular
reagents
All nucleic(67) cDNA(64) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000054423 (Evidence)
Entrez Gene 27062 (Evidence)
UniGene 260881
DFCI TC1601834, TC1601483, TC1580076
DoTS DT.40185468, DT.101381380, DT.101333074, DT.99838872, DT.94293365, DT.91370728
NIA Mouse Gene Index U035240
Consensus CDS Project CCDS36806.1, CCDS36807.1
International Mouse Phenotyping Consortium Status Cadps
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054423 Ensembl Gene Model | MGI Sequence Detail 450517 C57BL/6J ±  kb
transcript ENSMUST00000067491 Ensembl | MGI Sequence Detail 5478 Not Applicable 
polypeptide ENSMUSP00000064706 Ensembl | MGI Sequence Detail 1361 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(51) UniProt(3)
Polymorphisms
SNPs within 2kb(4132 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4134)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR010439 Calcium-dependent secretion activator
InterPro IPR014770 Munc13 homology 1
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000004964 calcium-dependent secretion activator 1
References
(Earliest) J:80393 Cisternas FA, et al., Cloning and characterization of human CADPS and CADPS2, new members of the Ca(2+)-dependent activator for secretion protein family. Genomics. 2003 Mar;81(3):279-91
(Latest) J:220237 Farina M, et al., CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. Elife. 2015;4
All references(50)
Other
accession IDs
MGI:2145766

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory