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Ppp2r5c Gene Detail
Summary
  • Symbol
    Ppp2r5c
  • Name
    protein phosphatase 2, regulatory subunit B', gamma
  • Synonyms
    2610043M05Rik, 2700063L20Rik, B56/PP2A gamma, Band 8A, D12Bwg0916e, mKIAA0044
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349475
    NCBI Gene: 26931
  • Gene Overview
    MyGene.info: PPP2R5C
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110447179-110583075 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 60.56 cM, cytoband F2
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1277 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349475
protein coding gene Chr12:110447120-110583075 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020117
protein coding gene Chr12:112747517-112889642 (+)
A/J MGP_AJ_G0020071
protein coding gene Chr12:108411256-108508216 (+)
AKR/J MGP_AKRJ_G0020047
protein coding gene Chr12:111550200-111687528 (+)
BALB/cJ MGP_BALBcJ_G0020057
protein coding gene Chr12:108856138-108993163 (+)
C3H/HeJ MGP_C3HHeJ_G0019859
protein coding gene Chr12:111999242-112138076 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020502
protein coding gene Chr12:116185587-116335844 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018114
protein coding gene Chr12:104874274-105023481 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019826
protein coding gene Chr12:120727570-120880465 (+)
DBA/2J MGP_DBA2J_G0019943
protein coding gene Chr12:107925916-108057800 (+)
FVB/NJ MGP_FVBNJ_G0019928
protein coding gene Chr12:106683393-106853989 (+)
LP/J MGP_LPJ_G0020018
protein coding gene Chr12:112578608-112725099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019966
protein coding gene Chr12:123858916-124009478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020531
protein coding gene Chr12:111077292-111176286 (+)
PWK/PhJ MGP_PWKPhJ_G0019160
protein coding gene Chr12:102540667-102679449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018964
protein coding gene Chr12:105239832-105340047 (+)
WSB/EiJ MGP_WSBEiJ_G0019458
protein coding gene Chr12:111947580-112084722 (+)



Homology
more
  • Human Ortholog
    PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP2R5C, protein phosphatase 2 regulatory subunit B'gamma
    Orthology source: HGNC
  • Synonyms
    B56G, B56gamma, PR61G
  • Links
    NCBI Gene ID: 5527
    neXtProt AC: NX_Q13362
    UniProt: Q13362

  • Chr Location
    14q32.31; chr14:101760573-101927992 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele show partial neonatal lethality, hypoactivity, and abnormal ventricular septum formation associated with increased fetal cardiomyocyte apoptosis. Surviving homozygotes develop obesity and show an abnormal gait, decreased grip strength, and impaired balance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26931 NCBI Gene Model | MGI Sequence Detail 135897 C57BL/6J ±  kb
    transcript NM_001364204 RefSeq | MGI Sequence Detail 4492 C57BL/6  
    polypeptide Q60996 UniProt | EBI | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013145 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 28
      Primer pair 5

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-34036, MGI:106344, MGI:1917494, MGI:1922861, MGI:2144759, MGI:2145038, MGI:3034420
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:51733 Francia G, et al., Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression. Cancer Res. 1996 Sep 1;56(17):3855-8
    • Latest
      J:252307 Sents W, et al., PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development. Cancer Res. 2017 Dec 15;77(24):6825-6837

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory