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Ecsit
Gene Detail
 Symbol
Name
ID
Ecsit
ECSIT homolog (Drosophila)
MGI:1349469
Synonyms Sitpec
Feature Type protein coding gene
Genetic Map
Chromosome 9
8.23 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:22072246-22085438 bp, - strand
From VEGA annotation of GRCm38

  13193 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ecsit

Human
homologs
Human Homolog ECSIT, ECSIT signalling integrator
NCBI Gene ID 51295
neXtProt AC  NX_Q9BQ95
Human Synonyms  SITPEC
Human Chr (Location)  19p13.2; chr19:11505916-11529172 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice die around the stage of gastrulation showing abnormal epiblast patterning.
 
Interactions
Ecsit interacts with 5 markers (Mir141, Mir191, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process BMP signaling pathway, immune system process, ...
Component cytoplasm, mitochondrion, ...
Function oxidoreductase activity, acting on NAD(P)H, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042363 (Evidence)
Ensembl Gene ModelENSMUSG00000066839 (Evidence)
Entrez Gene26940 (Evidence)
UniGene425568
DFCITC1577071, TC1594923, TC1629459
NIA Mouse Gene IndexU030602
Consensus CDS ProjectCCDS22920.1
International Mouse Knockout Project StatusEcsit
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042363 VEGA Gene Model | MGI Sequence Detail 13193 C57BL/6J ±  kb
transcript OTTMUST00000111647 VEGA | MGI Sequence Detail 1462 Not Applicable 
polypeptide OTTMUSP00000062548 VEGA | MGI Sequence Detail 435 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010418 ECSIT
Protein Ontology PR:000006884 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
References (Earliest) J:57233 Kopp E, et al., ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 1999 Aug 15;13(16):2059-71
(Latest) J:184896 Kondo T, et al., TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and IRF-3/7-mediated signal pathways. Biochem Biophys Res Commun. 2012 Jun 8;422(3):501-7
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory