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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ecsit
ECSIT signalling integrator
MGI:1349469
43 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ecsitmpc178H/Ecsit+
involves: 129S6/SvEvTac * BALB/c * C3H/HeH * C57BL/6J 		normal cardiovascular system phenotype J:388975
Ecsitmpc178H/Ecsitmpc178H
C3H.Cg-Pde6b+ Ecsitmpc178H/H 		abnormal heart echocardiography feature J:388975
abnormal mitochondrial biogenesis J:388975
abnormal mitochondrial physiology J:388975
abnormal myocardial fiber mitochondrial morphology J:388975
abnormal myocardial fiber morphology J:388975
abnormal respiratory electron transport chain J:388975
cardiomyopathy J:388975
decreased cardiac muscle contractility J:388975
decreased cardiac output J:388975
decreased cardiac stroke volume J:388975
decreased heart rate J:388975
decreased liver weight J:388975
decreased lymphocyte cell number J:388975
decreased macrophage cell number J:388975
decreased muscle cell respiration J:388975
decreased skeletal muscle fiber diameter J:388975
disorganized mitochondrial cristae J:388975
heart left ventricle hypertrophy J:388975
normal immune system phenotype J:388975
increased heart left ventricle anterior wall thickness J:388975
increased heart left ventricle posterior wall thickness J:388975
increased heart left ventricle size J:388975
increased heart left ventricle weight J:388975
increased heart weight J:388975
increased lung weight J:388975
increased myocardial fiber mitochondrial DNA content J:388975
increased myocardial fiber size J:388975
myocardial fiber degeneration J:388975
myocardial fiber disarray J:388975
premature death J:388975
Ecsitmpc178H/Ecsitmpc178H
involves: BALB/c * C3H/HeH * C57BL/6J 		abnormal coat appearance J:388975
abnormal myocardial fiber morphology J:388975
cardiomyopathy J:234901, J:388975
enlarged heart J:388975
hunched posture J:388975
hypoactivity J:388975
increased myocardial fiber size J:388975
myocardial fiber degeneration J:388975
myocardial fiber disarray J:388975
premature death J:388975
weight loss J:388975
Ecsitmpc178H/Ecsittm1Gho
involves: 129S6/SvEvTac * BALB/c * C3H/HeH * C57BL/6J 		cardiac hypertrophy J:388975
increased heart weight J:388975
Ecsittm1Gho/Ecsit+
involves: 129S6/SvEvTac * BALB/c * C3H/HeH * C57BL/6J 		normal cardiovascular system phenotype J:388975
Ecsittm1Gho/Ecsittm1Gho
involves: 129S6/SvEvTac * C57BL/6 		abnormal mesoderm development J:86912
absent mesoderm J:86912
decreased cell proliferation J:86912
decreased embryo size J:86912
embryonic lethality during organogenesis, complete penetrance J:86912
thick embryonic epiblast J:86912
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/14/2026
MGI 6.24 		The Jackson Laboratory