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Cops6 Gene Detail
Summary
  • Symbol
    Cops6
  • Name
    COP9 signalosome subunit 6
  • Synonyms
    COP9 complex S6, Sgn3, VIP/MOV34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349439
    NCBI Gene: 26893
  • Gene Overview
    MyGene.info: COPS6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:138161102-138163984 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.97 cM, cytoband G1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349439
protein coding gene Chr5:138161071-138164646 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030256
protein coding gene Chr5:142956152-142959727 (+)
A/J MGP_AJ_G0030224
protein coding gene Chr5:136775441-136779016 (+)
AKR/J MGP_AKRJ_G0030156
protein coding gene Chr5:141222774-141226349 (+)
BALB/cJ MGP_BALBcJ_G0030238
protein coding gene Chr5:138135053-138138628 (+)
C3H/HeJ MGP_C3HHeJ_G0029951
protein coding gene Chr5:141855532-141859107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030685
protein coding gene Chr5:148310362-148313937 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027903
protein coding gene Chr5:130909623-130913108 (+)
CAST/EiJ MGP_CASTEiJ_G0029357
protein coding gene Chr5:141234815-141238415 (+)
CBA/J MGP_CBAJ_G0029922
protein coding gene Chr5:154187170-154190745 (+)
DBA/2J MGP_DBA2J_G0030070
protein coding gene Chr5:136674319-136677894 (+)
FVB/NJ MGP_FVBNJ_G0030028
protein coding gene Chr5:135837641-135841216 (+)
LP/J MGP_LPJ_G0030159
protein coding gene Chr5:143491256-143495187 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030059
protein coding gene Chr5:157010908-157014483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030726
protein coding gene Chr5:141063645-141067220 (+)
PWK/PhJ MGP_PWKPhJ_G0029071
protein coding gene Chr5:135733616-135737187 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028907
protein coding gene Chr5:138624519-138628146 (+)
WSB/EiJ MGP_WSBEiJ_G0029432
protein coding gene Chr5:141750889-141754463 (+)



Homology
more
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSN6, MOV34-34KD
  • Links
    NCBI Gene ID: 10980
    neXtProt AC: NX_Q7L5N1
    UniProt: Q7L5N1

  • Chr Location
    7q22.1; chr7:100088960-100092200 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    4 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele or a transgenic gene disruption exhibit embryonic lethality. Mice heterozygous for a gene trap allele exhibit increased sensitivity to irradiation and decreased incidence of ionizing radiation-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26893 NCBI Gene Model | MGI Sequence Detail 2883 C57BL/6J ±  kb
transcript NM_012002 RefSeq | MGI Sequence Detail 1094 C57BL/6  
polypeptide O88545 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 144
    cDNA 144

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:225145 Chen J, et al., CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory