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Cops6 Gene Detail
Summary
  • Symbol
    Cops6
  • Name
    COP9 signalosome subunit 6
  • Synonyms
    COP9 complex S6, Sgn3, VIP/MOV34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349439
    NCBI Gene: 26893
  • Gene Overview
    MyGene.info: COPS6
Location & Maps
more
  • Sequence Map
    Chr5:138161071-138164646 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3576 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.97 cM, cytoband G1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COPS6, COP9 signalosome subunit 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSN6, MOV34-34KD
  • Links
    NCBI Gene ID: 10980
    neXtProt AC: NX_Q7L5N1

  • Chr Location
    7q22.1; chr7:100088960-100092200 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    15
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a gene trap allele or a transgenic gene disruption exhibit embryonic lethality. Mice heterozygous for a gene trap allele exhibit increased sensitivity to irradiation and decreased incidence of ionizing radiation-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022638 VEGA Gene Model | MGI Sequence Detail 3576 C57BL/6J ±  kb
transcript OTTMUST00000054245 VEGA | MGI Sequence Detail 1787 Not Applicable  
polypeptide OTTMUSP00000025868 VEGA | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005743 COP9 signalosome complex subunit 6
  • InterPro Domains
    IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
    IPR024969 Rpn11/EIF3F, C-terminal
Molecular
Reagents
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  • All nucleic 143
    cDNA 143

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:225145 Chen J, et al., CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory