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Figla Gene Detail
Summary
  • Symbol
    Figla
  • Name
    folliculogenesis specific basic helix-loop-helix
  • Synonyms
    bHLHc8, FIG alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349421
    NCBI Gene: 26910
  • Gene Overview
    MyGene.info: FIGLA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:86016171-86020996 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4826 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.55 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BHLHC8, FIGALPHA, POF6
  • Links
    NCBI Gene ID: 344018
    neXtProt AC: NX_Q6QHK4
    UniProt: Q6QHK4

  • Chr Location
    2p13.3; chr2:70777310-70790643 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human FIGLA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in female sterility owing to an absence of primordial follicles and oocyte depletion. Mutant males are fertile and exhibit no apparent defects of the reproductive system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000056193 VEGA Gene Model | MGI Sequence Detail 4826 C57BL/6J ±  kb
    transcript OTTMUST00000138922 VEGA | MGI Sequence Detail 759 Not Applicable  
    polypeptide OTTMUSP00000072970 VEGA | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      123 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 3
      Primer pair 5
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 18
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:51735 Liang L, et al., FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec;124(24):4939-47
    • Latest
      J:238887 Park MW, et al., Associations among Sebox and other MEGs and its effects on early embryogenesis. PLoS One. 2015;10(2):e0115050

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory