About   Help   FAQ
Figla Gene Detail
Summary
  • Symbol
    Figla
  • Name
    folliculogenesis specific basic helix-loop-helix
  • Synonyms
    bHLHc8, FIG alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349421
    NCBI Gene: 26910
  • Gene Overview
    MyGene.info: FIGLA
Location & Maps
more
  • Sequence Map
    Chr6:86016171-86020996 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4826 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BHLHC8, FIGALPHA, POF6
  • Links
    NCBI Gene ID: 344018
    neXtProt AC: NX_Q6QHK4

  • Chr Location
    2p13.3; chr2:70777310-70790643 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FIGLA associations

Human Disease Mouse Models
       Premature Ovarian Failure 6; POF6   OMIM: 612310
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Figla
Inactivation of this locus results in female sterility owing to an absence of primordial follicles and oocyte depletion. Mutant males are fertile and exhibit no apparent defects of the reproductive system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056193 VEGA Gene Model | MGI Sequence Detail 4826 C57BL/6J ±  kb
transcript OTTMUST00000138922 VEGA | MGI Sequence Detail 759 Not Applicable  
polypeptide OTTMUSP00000072970 VEGA | MGI Sequence Detail 194 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007521 factor in the germline alpha
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 3
    Primer pair 4
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 18
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:51735 Liang L, et al., FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec;124(24):4939-47
  • Latest
    J:213801 Padua MB, et al., Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary. Biol Reprod. 2014 Jul;91(1):24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory