About   Help   FAQ
Figla
Gene Detail
 Symbol
Name
ID
Figla
folliculogenesis specific basic helix-loop-helix
MGI:1349421
Synonyms bHLHc8, FIG alpha
Feature Type protein coding gene
Genetic Map
Chromosome 6
37.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:86017191-86020996 bp, + strand
From NCBI annotation of GRCm38

  3806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Figla

Human
homologs
Human Homolog FIGLA, folliculogenesis specific basic helix-loop-helix
NCBI Gene ID 344018
neXtProt AC  NX_Q6QHK4
Human Synonyms  BHLHC8, FIGALPHA, POF6
Human Chr (Location)  2p13.3; chr2:70777310-70790643 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FIGLA
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Inactivation of this locus results in female sterility owing to an absence of primordial follicles and oocyte depletion. Mutant males are fertile and exhibit no apparent defects of the reproductive system.
 
Interactions
Figla interacts with 25 markers (Mir92-1, Mir144, Mir182, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (107)    Tissues (105)    Images (2)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
RT-PCR 13
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(3) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030001 (Evidence)
Entrez Gene26910 (Evidence)
UniGene8024
DFCITC1595489
DoTSDT.91332922
Consensus CDS ProjectCCDS20307.1
International Mouse Knockout Project StatusFigla
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26910 NCBI Gene Model | MGI Sequence Detail 3806 C57BL/6J ±  kb
transcript NM_012013 RefSeq | MGI Sequence Detail 759 Not Specified 
polypeptide O55208 UniProt | EBI | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000007521 factor in the germline alpha
Graphical View of Protein Domain Structure
References (Earliest) J:51735 Liang L, et al., FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec;124(24):4939-47
(Latest) J:209947 Lin RS, et al., Figla-Cre transgenic mice expressing myristoylated EGFP in germ cells provide a model for investigating perinatal oocyte dynamics. PLoS One. 2014;9(1):e84477
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory