Figla
Gene Detail

Symbol Name ID

Figla folliculogenesis specific basic helix-loop-helix MGI:1349421

Synonyms

bHLHc8, FIG alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 6

37.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:86017191-86020996 bp, + strand From NCBI annotation of GRCm38   3806 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Figla

Human homologs

Human Homolog		FIGLA, folliculogenesis specific basic helix-loop-helix
NCBI Gene ID		344018
neXtProt AC		NX_Q6QHK4
Human Synonyms		BHLHC8, FIGALPHA, POF6
Human Chr (Location)		2p13.3; chr2:71004442-71017775 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FIGLA

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Inactivation of this locus results in female sterility owing to an absence of primordial follicles and oocyte depletion. Mutant males are fertile and exhibit no apparent defects of the reproductive system.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (107)    Tissues (105)    Images (2)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	13

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(3) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030001 (Evidence)
Entrez Gene	26910 (Evidence)
UniGene	8024
DFCI	TC1595489
DoTS	DT.91332922
Consensus CDS Project	CCDS20307.1
International Mouse Knockout Project Status	Figla

Sequences

Length	Strain/Species
genomic	26910	NCBI Gene Model | MGI Sequence Detail	3806	C57BL/6J
transcript	NM_012013	RefSeq | MGI Sequence Detail	759	Not Specified
polypeptide	O55208	UniProt | EBI | MGI Sequence Detail	194	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000007521	factor in the germline alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:51735 Liang L, et al., FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec;124(24):4939-47
(Latest) J:172213 Gill ME, et al., Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7443-8
All references(40)