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Figla Gene Detail
Summary
  • Symbol
    Figla
  • Name
    folliculogenesis specific basic helix-loop-helix
  • Synonyms
    bHLHc8, FIG alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349421
    NCBI Gene: 26910
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85993476-85997978 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.55 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349421
 protein coding gene Chr6:85993153-85997978 (+)
129S1/SvImJ ENSMUSG00200043013
 protein coding gene Chr6:82950849-82954659 (+)
A/J ENSMUSG00195038212
 protein coding gene Chr6:82635163-82638974 (+)
AKR/J ENSMUSG00220027671
 protein coding gene Chr6:81545640-81549445 (+)
BALB/cJ ENSMUSG00180014960
 protein coding gene Chr6:83020477-83024282 (+)
C3H/HeJ ENSMUSG00175037014
 protein coding gene Chr6:94390340-94394151 (-)
C57BL/6NJ ENSMUSG00215024766
 protein coding gene Chr6:83015869-83019674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028589
 protein coding gene Chr6:82069412-82073368 (+)
CAST/EiJ ENSTCUG00005018073
 protein coding gene Chr6:82951470-82955305 (+)
CBA/J ENSMUSG00210037668
 protein coding gene Chr6:82826346-82830157 (+)
DBA/2J ENSMUSG00185043383
 protein coding gene Chr6:83373485-83377296 (+)
FVB/NJ ENSMUSG00205025934
 protein coding gene Chr6:82004354-82008165 (+)
JF1/MsJ ENSUMUG00000017558
 protein coding gene Chr6:82324249-82328091 (+)
LP/J ENSMUSG00230047140
 protein coding gene Chr6:84507500-84511310 (+)
NOD/ShiLtJ ENSMUSG00190042723
 protein coding gene Chr6:82450097-82453908 (+)
NZO/HlLtJ ENSMUSG00225018893
 protein coding gene Chr6:86471370-86475182 (+)
PWK/PhJ ENSLUMG00010006230
 protein coding gene Chr6:81730239-81734038 (+)
SPRET/EiJ ENSMSPG00010034683
 protein coding gene Chr6:83880217-83884030 (+)
WSB/EiJ ENSIUOG00005031207
 protein coding gene Chr6:83355337-83359148 (+)



Homology
more
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIGLA, folliculogenesis specific bHLH transcription factor
  • Synonyms
    BHLHC8, FIGALPHA, POF6
  • Links
    NCBI Gene ID: 344018
    UniProt: Q6QHK4

  • Chr Location
    2p13.3; chr2:70777310-70790643 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FIGLA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in female sterility owing to an absence of primordial follicles and oocyte depletion. Mutant males are fertile and exhibit no apparent defects of the reproductive system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    120
  • cDNA Data
    4
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26910 NCBI Gene Model | MGI Sequence Detail 4503 C57BL/6J ±  kb
    transcript NM_012013 RefSeq | MGI Sequence Detail 759 C57BL/6  
    polypeptide O55208 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007521 factor in the germline alpha
      (term hierarchy)
    • InterPro Domains
      IPR050283 E-box Binding Transcriptional Regulators
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 4
      Primer pair 7
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 22
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:51735 Liang L, et al., FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development. 1997 Dec;124(24):4939-47
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory