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Sh2d1b1 Gene Detail
Summary
  • Symbol
    Sh2d1b1
  • Name
    SH2 domain containing 1B1
  • Synonyms
    Eat2, EAT-2, Eat2a, Sh2d1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349420
    NCBI Gene: 26904
  • Gene Overview
    MyGene.info: SH2D1B
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:170277324-170285662 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349420
protein coding gene Chr1:170277320-170286769 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016728
protein coding gene Chr1:175967400-175979195 (+)
A/J MGP_AJ_G0016708
protein coding gene Chr1:168791028-168803470 (+)
AKR/J MGP_AKRJ_G0016674
protein coding gene Chr1:173857601-173868133 (+)
BALB/cJ MGP_BALBcJ_G0016669
protein coding gene Chr1:169278132-169287738 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0017130
protein coding gene Chr1:181800541-181813734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014839
protein coding gene Chr1:160489641-160541499 (+)
CAST/EiJ MGP_CASTEiJ_G0016073
protein coding gene Chr1:173735640-173744064 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0016574
protein coding gene Chr1:167653018-167664240 (+)
FVB/NJ MGP_FVBNJ_G0016571
protein coding gene Chr1:166016997-166026304 (+)
LP/J MGP_LPJ_G0016645
protein coding gene Chr1:177088949-177102568 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016597
protein coding gene Chr1:195606255-195618082 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017167
protein coding gene Chr1:173751354-173766195 (+)
PWK/PhJ MGP_PWKPhJ_G0015859
protein coding gene Chr1:166889916-166902074 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016135
protein coding gene Chr1:173878101-173891389 (+)



Homology
more
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAT2
  • Links
    NCBI Gene ID: 117157
    neXtProt AC: NX_O14796
    UniProt: O14796

  • Chr Location
    1q23.3; chr1:162395266-162412138 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit NK cells with enhanced cytolytic capacity and an increased IFN-gamma secretion. Mice homozygous for a different knock-out allele exhibit impaired NK cell cytolysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26904 NCBI Gene Model | MGI Sequence Detail 8339 C57BL/6J ±  kb
transcript NM_012009 RefSeq | MGI Sequence Detail 2546 C57BL/6  
polypeptide O35324 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:51754 Thompson AD, et al., EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene. 1996 Dec 19;13(12):2649-58
  • Latest
    J:259468 Wu N, et al., A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nat Immunol. 2016 Apr;17(4):387-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory