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Sh2d1b1 Gene Detail
Summary
  • Symbol
    Sh2d1b1
  • Name
    SH2 domain containing 1B1
  • Synonyms
    Eat2, EAT-2, Eat2a, Sh2d1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349420
    NCBI Gene: 26904
  • Gene Overview
    MyGene.info: SH2D1B
Location & Maps
more
  • Sequence Map
    Chr1:170277320-170286769 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9450 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
    Orthology source: HomoloGene
  • Synonyms
    EAT2
  • Links
    NCBI Gene ID: 117157
    neXtProt AC: NX_O14796

  • Chr Location
    1q23.3; chr1:162395266-162412138 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    2 involving Sh2d1b1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit NK cells with enhanced cytolytic capacity and an increased IFN-gamma secretion. Mice homozygous for a different knock-out allele exhibit impaired NK cell cytolysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049940 VEGA Gene Model | MGI Sequence Detail 9450 C57BL/6J ±  kb
transcript OTTMUST00000127120 VEGA | MGI Sequence Detail 2544 Not Applicable  
polypeptide OTTMUSP00000068669 VEGA | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    161 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:51754 Thompson AD, et al., EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Oncogene. 1996 Dec 19;13(12):2649-58
  • Latest
    J:212410 Perez-Quintero LA, et al., EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cgamma, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014 Apr 7;211(4):727-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory