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Map4k4 Gene Detail
Summary
  • Symbol
    Map4k4
  • Name
    mitogen-activated protein kinase kinase kinase kinase 4
  • Synonyms
    9430080K19Rik, Nik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349394
    NCBI Gene: 26921
  • Gene Overview
    MyGene.info: MAP4K4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:39900913-40026310 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 18.53 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1185 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349394
protein coding gene Chr1:39900912-40026310 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015963
protein coding gene Chr1:38670239-38805652 (+)
A/J MGP_AJ_G0015947
protein coding gene Chr1:37577624-37705815 (+)
AKR/J MGP_AKRJ_G0015902
protein coding gene Chr1:38077173-38201530 (+)
BALB/cJ MGP_BALBcJ_G0015901
protein coding gene Chr1:37230785-37364259 (+)
C3H/HeJ MGP_C3HHeJ_G0015734
protein coding gene Chr1:38352097-38481390 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016354
protein coding gene Chr1:40267371-40400663 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014076
protein coding gene Chr1:34532666-34657413 (+)
CAST/EiJ MGP_CASTEiJ_G0015315
protein coding gene Chr1:38253345-38393133 (+)
CBA/J MGP_CBAJ_G0015706
protein coding gene Chr1:41442947-41583880 (+)
DBA/2J MGP_DBA2J_G0015807
protein coding gene Chr1:36868381-36994725 (+)
FVB/NJ MGP_FVBNJ_G0015809
protein coding gene Chr1:36403770-36538619 (+)
LP/J MGP_LPJ_G0015877
protein coding gene Chr1:39006740-39138980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015829
protein coding gene Chr1:43485192-43612478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016401
protein coding gene Chr1:38213367-38346724 (+)
PWK/PhJ MGP_PWKPhJ_G0015098
protein coding gene Chr1:36688055-36820319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014880
protein coding gene Chr1:38148728-38289974 (+)
WSB/EiJ MGP_WSBEiJ_G0015377
protein coding gene Chr1:38173576-38303634 (+)



Homology
more
  • Human Ortholog
    MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP4K4, mitogen-activated protein kinase kinase kinase kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FLH21957, HEL-S-31, HGK, MEKKK4, NIK
  • Links
    NCBI Gene ID: 9448
    neXtProt AC: NX_O95819
    UniProt: O95819

  • Chr Location
    2q11.2; chr2:101697703-101894690 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7442
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MAP4K4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos around day E9.5-10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026074 Ensembl Gene Model | MGI Sequence Detail 125398 C57BL/6J ±  kb
    transcript ENSMUST00000195860 Ensembl | MGI Sequence Detail 3960 Not Applicable  
    polypeptide ENSMUSP00000141400 Ensembl | MGI Sequence Detail 1288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-39589, MGI:109590, MGI:1915370, MGI:2138498, MGI:2138507, MGI:2138541
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:39300 Su YC, et al., NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997 Mar 17;16(6):1279-90
    • Latest
      J:254075 Larhammar M, et al., The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. J Neurosci. 2017 Nov 15;37(46):11074-11084

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory