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Ror1
Gene Detail
Symbol

Name
ID
Ror1
receptor tyrosine kinase-like orphan receptor 1
MGI:1347520
Synonyms
2810404D04Rik, Ntrkr1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
45.71 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:100095791-100444765 bp, + strand
From VEGA annotation of GRCm38

  348975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ROR1
Protein SuperFamily: tyrosine-protein kinase transmembrane receptor ROR
Gene Tree: Ror1

Human
homologs
ROR1, receptor tyrosine kinase-like orphan receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4919
neXtProt AC: NX_Q01973

Human Synonyms: dJ537F10.1, NTRKR1

Human Chr (Location): 1p31.3; chr1:63774019-64181498 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(7) Transgenic(1)
Genomic Mutations involving Ror1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some disruptions in this gene die within the first day after birth from respiratory defects.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Ror1 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process peptidyl-tyrosine phosphorylation, phosphorylation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (251)    Tissues (247)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 251
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ror1    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000008027 (Evidence)
Ensembl Gene Model ENSMUSG00000035305 (Evidence)
Entrez Gene 26563 (Evidence)
DFCI TC1672998, TC1582654, TC1756683
DoTS DT.91306656, DT.55256966, DT.110802647, DT.110802590
NIA Mouse Gene Index U004540
EC 2.7.10.1
Consensus CDS Project CCDS18389.1
International Mouse Phenotyping Consortium Status Ror1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008027 VEGA Gene Model | MGI Sequence Detail 348975 C57BL/6J ±  kb
transcript OTTMUST00000018165 VEGA | MGI Sequence Detail 5762 Not Applicable 
polypeptide OTTMUSP00000008344 VEGA | MGI Sequence Detail 937 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(2788 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016247 Tyrosine-protein kinase, receptor ROR
Protein Ontology PR:000014161 tyrosine-protein kinase transmembrane receptor ROR1
References
(Earliest) J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
(Latest) J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
All references(43)
Other
accession IDs
MGI:1919426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory