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Ror1
Gene Detail
 Symbol
Name
ID
Ror1
receptor tyrosine kinase-like orphan receptor 1
MGI:1347520
Synonyms 2810404D04Rik, Ntrkr1
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.71 cM, cytoband C6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:100095791-100444765 bp, + strand
From VEGA annotation of GRCm38

  348975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase transmembrane receptor ROR
Gene Tree: Ror1

Human
homologs
Human Homolog ROR1, receptor tyrosine kinase-like orphan receptor 1
NCBI Gene ID 4919
neXtProt AC  NX_Q01973
Human Synonyms  dJ537F10.1, NTRKR1
Human Chr (Location)  1p32-p31; chr1:63774019-64181498 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for some disruptions in this gene die within the first day after birth from respiratory defects.
 
Phenotype Images(4)
Interactions
Ror1 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process peptidyl-tyrosine phosphorylation, phosphorylation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (251)    Tissues (247)    Images (33)
Theiler Stages: 11, 13, 15, 17, 20, 21, 22, 25, 26, 28
Assay TypeResults
RNA in situ 251
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000008027 (Evidence)
Ensembl Gene ModelENSMUSG00000035305 (Evidence)
Entrez Gene26563 (Evidence)
DFCITC1582654, TC1672998, TC1756683
DoTSDT.110802590, DT.110802647, DT.55256966, DT.91306656
NIA Mouse Gene IndexU004540
EC2.7.10.1
Consensus CDS ProjectCCDS18389.1
International Mouse Knockout Project StatusRor1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008027 VEGA Gene Model | MGI Sequence Detail 348975 C57BL/6J ±  kb
transcript OTTMUST00000018165 VEGA | MGI Sequence Detail 5762 Not Applicable 
polypeptide OTTMUSP00000008344 VEGA | MGI Sequence Detail 937 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2788 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016247 Tyrosine-protein kinase, receptor ROR
Protein Ontology PR:000014161 tyrosine-protein kinase transmembrane receptor ROR1
References (Earliest) J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(44)
Other
accession IDs
MGI:1919426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory