Ror1 MGI Mouse Gene Detail - MGI:1347520 - receptor tyrosine kinase-like orphan receptor 1

Symbol

Ror1
Name

receptor tyrosine kinase-like orphan receptor 1
Synonyms

2810404D04Rik, Ntrkr1

Feature Type

protein coding gene
IDs

MGI:1347520
NCBI Gene: 26563
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:99952988-100301962 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 45.71 cM, cytoband C6
Mapping Data

4 experiments

SNPs within 2kb

9701 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347520	protein coding gene	Chr4:99952988-100302003 (+)
129S1/SvImJ	ENSMUSG00200026636	protein coding gene	Chr4:94934267-95313781 (+)
A/J	ENSMUSG00195008208	protein coding gene	Chr4:95497770-95857557 (+)
AKR/J	ENSMUSG00220006490	protein coding gene	Chr4:94938254-95295769 (+)
BALB/cJ	ENSMUSG00180029417	protein coding gene	Chr4:94426765-94786571 (+)
C3H/HeJ	ENSMUSG00175013114	protein coding gene	Chr4:95388928-95748675 (+)
C57BL/6NJ	ENSMUSG00215008925	protein coding gene	Chr4:95326713-95675792 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026198	protein coding gene	Chr4:92191190-92539811 (+)
CAST/EiJ	ENSTCUG00005006916	protein coding gene	Chr4:94633808-94983020 (+)
CBA/J	ENSMUSG00210028423	protein coding gene	Chr4:94961121-95320905 (+)
DBA/2J	ENSMUSG00185021139	protein coding gene	Chr4:95723194-96072258 (+)
FVB/NJ	ENSMUSG00205010455	protein coding gene	Chr4:93929139-94283600 (+)
JF1/MsJ	ENSUMUG00000040611	protein coding gene	Chr4:95826889-96179797 (+)
LP/J	ENSMUSG00230018946	protein coding gene	Chr4:99043670-99403283 (+)
NOD/ShiLtJ	ENSMUSG00190023479	protein coding gene	Chr4:94400524-94760168 (+)
NZO/HlLtJ	ENSMUSG00225032170	protein coding gene	Chr4:104165802-104525643 (+)
PWK/PhJ	ENSLUMG00010018316	protein coding gene	Chr4:93520462-93877188 (+)
SPRET/EiJ	ENSMSPG00010007981	protein coding gene	Chr4:95750783-96109317 (+)
WSB/EiJ	ENSIUOG00005002585	protein coding gene	Chr4:94723633-95080300 (+)

Human Ortholog

ROR1, ROR family WNT receptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ROR1, ROR family WNT receptor 1
Synonyms

dJ537F10.1, NTRKR1
Links

HGNC:10256

NCBI Gene ID: 4919

UniProt: Q01973
Chr Location

1p31.3; chr1:63774017-64181498 (+) GRCh38

MGI Vertebrate Homology

Ror1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ROR1
Protein SuperFamily

TyrPK_TMrec_ROR
Gene Tree

Ror1

Diseases

1 with human ROR1 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 108 IDs autosomal recessive nonsyndromic deafness 108 DOID:0080263 OMIM:617654

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

26 phenotypes from 3 alleles in 4 genetic backgrounds
20 phenotypes from multigenic genotypes
4 images
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

3
Radiation induced

1
Targeted

8
Genomic Mutations

4 involving Ror1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for some disruptions in this gene die within the first day after birth from respiratory defects.

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All GO Annotations

42
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

952
Tissues

293
cDNA Data

13
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ROR1

Xenbase ror1

ZFIN ror1

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All Sequences

46
RefSeq

6
UniProt

3
CCDS

CCDS18389.1

Ensembl

ENSMUSG00000035305 (Evidence)
NCBI Gene

26563

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035305	Ensembl Gene Model \| MGI Sequence Detail	348975	C57BL/6J	± kb
transcript	ENSMUST00000039630	Ensembl \| MGI Sequence Detail	5762	Not Applicable
polypeptide	ENSMUSP00000048171	Ensembl \| MGI Sequence Detail	937	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014161 tyrosine-protein kinase transmembrane receptor ROR1

(term hierarchy)
InterPro Domains

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR003599 Immunoglobulin domain subtype

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR000001 Kringle

IPR018056 Kringle, conserved site

IPR013806 Kringle-like fold

IPR038178 Kringle superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR016247 Tyrosine-protein kinase, receptor ROR
GlyGen

Q9Z139 5 sites, 2 N-linked glycans (2 sites)

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All nucleic 20

cDNA 13

Primer pair 5

Other 2

Antibodies 1

Microarray probesets 6

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MGI:1919426

Summaries

All 84

Developmental Gene Expression 23

Gene Ontology 12

Phenotypes 31
Earliest

J:57217 Oishi I, et al., Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells. 1999 Jan;4(1):41-56
Latest

J:391808 Haykir B, et al., ROR1/ROR2 regulate aldosterone production from the zona glomerulosa. Endocrinology. 2026 Jul 8;167(8)

TSS for Ror1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37957	Chr4:99953000-99953064 (+)	44 bp
Tssr37958	Chr4:99953074-99953086 (+)	92 bp
Tssr37959	Chr4:100002272-100002278 (+)	49,287 bp
Tssr37960	Chr4:100017322-100017326 (+)	64,336 bp
Tssr37961	Chr4:100084927-100084928 (+)	131,940 bp
Tssr37962	Chr4:100162851-100162856 (+)	209,866 bp
Tssr37963	Chr4:100194055-100194058 (+)	241,069 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24