Foxm1
Gene Detail

Symbol Name ID

Foxm1 forkhead box M1 MGI:1347487

Synonyms

Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN

Feature Type

protein coding gene

Genetic Map

Chromosome 6

62.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:128362967-128375893 bp, + strand From VEGA annotation of GRCm38   12927 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxm1

Human homologs

Human Homolog		FOXM1, forkhead box M1
NCBI Gene ID		2305
neXtProt AC		NX_Q08050
Human Synonyms		FKHL16, FOXM1B, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TGT3, TRIDENT
Human Chr (Location)		12p13; chr12:2966847-2986321 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardial defects and polyploidy in heart and liver.

 
Human Diseases Modeled Using Mouse Foxm1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	cell cycle, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (34 records)
Data Summary: Results (248)    Tissues (218)    Images (33)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	195
Northern blot	15
RT-PCR	15

cDNA source data(108)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(112) Genomic(2) cDNA(108) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023770 (Evidence)
Ensembl Gene Model	ENSMUSG00000001517 (Evidence)
Entrez Gene	14235 (Evidence)
UniGene	42148
DoTS	DT.101407943, DT.490469, DT.91288950, DT.91332014
Consensus CDS Project	CCDS20570.1
International Mouse Knockout Project Status	Foxm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023770	VEGA Gene Model | MGI Sequence Detail	12927	C57BL/6J
transcript	OTTMUST00000058073	VEGA | MGI Sequence Detail	4399	Not Applicable
polypeptide	OTTMUSP00000028087	VEGA | MGI Sequence Detail	757	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007635	forkhead box protein M1

References

(Earliest) J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
(Latest) J:194103 Ren X, et al., FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol. 2013 Jan;33(2):371-86
All references(97)

Other accession IDs

MGI:2141700, MGI:2141741, MGI:894699