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Foxm1
Gene Detail
Symbol

Name
ID
Foxm1
forkhead box M1
MGI:1347487
Synonyms
Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN
Feature Type
protein coding gene
Genetic Map
Chromosome 6
62.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:128362967-128375893 bp, + strand
From VEGA annotation of GRCm38

  12927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXM1
Gene Tree: Foxm1

Human
homologs
FOXM1, forkhead box M1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2305
neXtProt AC: NX_Q08050

Human Synonyms: FKHL16, FOXM1B, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TGT3, TRIDENT

Human Chr (Location): 12p13; chr12:2857681-2877155 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardial defects and polyploidy in heart and liver.
 
Human Diseases Modeled in Mice Using Foxm1 (3)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Foxm1 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process anatomical structure morphogenesis, cell cycle, ...
Component cytoplasm, intracellular, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (241)    Tissues (222)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 195
Northern blot 15
RT-PCR 8
cDNA source data(108)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase foxm1 ; ZFIN foxm1    NEW 
Molecular
reagents
All nucleic(112) Genomic(2) cDNA(108) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000023770 (Evidence)
Ensembl Gene Model ENSMUSG00000001517 (Evidence)
Entrez Gene 14235 (Evidence)
UniGene 42148
DoTS DT.101407943, DT.490469, DT.91288950, DT.91332014
Consensus CDS Project CCDS20570.1
International Mouse Phenotyping Consortium Status Foxm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023770 VEGA Gene Model | MGI Sequence Detail 12927 C57BL/6J ±  kb
transcript OTTMUST00000058073 VEGA | MGI Sequence Detail 4399 Not Applicable 
polypeptide OTTMUSP00000028087 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007635 forkhead box protein M1
References
(Earliest) J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
(Latest) J:221298 Wang Y, et al., Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ Res. 2014 Mar 14;114(6):957-65
All references(108)
Disease annotation references (3)
Other
accession IDs
MGI:2141700, MGI:2141741, MGI:894699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory