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Foxm1
Gene Detail
 Symbol
Name
ID
Foxm1
forkhead box M1
MGI:1347487
Synonyms Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN
Feature Type protein coding gene
Genetic Map
Chromosome 6
62.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:128362967-128375893 bp, + strand
From VEGA annotation of GRCm38

  12927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxm1

Human
homologs
Human Homolog FOXM1, forkhead box M1
NCBI Gene ID 2305
neXtProt AC  NX_Q08050
Human Synonyms  FKHL16, FOXM1B, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TGT3, TRIDENT
Human Chr (Location)  12p13; chr12:2857681-2877155 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Gene trapped(6) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardial defects and polyploidy in heart and liver.
 
Human Diseases Modeled Using Mouse Foxm1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component cytoplasm, intracellular, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (248)    Tissues (218)    Images (33)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 23
RNA in situ 195
Northern blot 15
RT-PCR 15
cDNA source data(108)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(112) Genomic(2) cDNA(108) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023770 (Evidence)
Ensembl Gene ModelENSMUSG00000001517 (Evidence)
Entrez Gene14235 (Evidence)
UniGene42148
DoTSDT.101407943, DT.490469, DT.91288950, DT.91332014
Consensus CDS ProjectCCDS20570.1
International Mouse Knockout Project StatusFoxm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023770 VEGA Gene Model | MGI Sequence Detail 12927 C57BL/6J ±  kb
transcript OTTMUST00000058073 VEGA | MGI Sequence Detail 4399 Not Applicable 
polypeptide OTTMUSP00000028087 VEGA | MGI Sequence Detail 757 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007635 forkhead box protein M1
References (Earliest) J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
(Latest) J:210591 Aytes A, et al., Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014 May 12;25(5):638-51
All references(103)
Other
accession IDs
MGI:2141700, MGI:2141741, MGI:894699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory