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Foxm1 Gene Detail
Summary
  • Symbol
    Foxm1
  • Name
    forkhead box M1
  • Synonyms
    Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347487
    NCBI Gene: 14235
  • Gene Overview
    MyGene.info: FOXM1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128362994-128375886 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347487
protein coding gene Chr6:128362967-128376146 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031322
protein coding gene Chr6:131964112-131977230 (+)
A/J MGP_AJ_G0031293
protein coding gene Chr6:126906191-126919269 (+)
AKR/J MGP_AKRJ_G0031221
protein coding gene Chr6:130320924-130334079 (+)
BALB/cJ MGP_BALBcJ_G0031300
protein coding gene Chr6:126481510-126494633 (+)
C3H/HeJ MGP_C3HHeJ_G0031024
protein coding gene Chr6:130461905-130475065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031759
protein coding gene Chr6:135401074-135414276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028905
protein coding gene Chr6:124109715-124123041 (+)
CAST/EiJ MGP_CASTEiJ_G0030405
protein coding gene Chr6:130749763-130762913 (+)
CBA/J MGP_CBAJ_G0030985
protein coding gene Chr6:140627121-140640285 (+)
DBA/2J MGP_DBA2J_G0031141
protein coding gene Chr6:125799423-125812622 (+)
FVB/NJ MGP_FVBNJ_G0031091
protein coding gene Chr6:124729886-124743029 (+)
LP/J MGP_LPJ_G0031221
protein coding gene Chr6:132087665-132100824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031129
protein coding gene Chr6:144465651-144478784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031792
protein coding gene Chr6:130336814-130349972 (+)
PWK/PhJ MGP_PWKPhJ_G0030120
protein coding gene Chr6:124096683-124110120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029949
protein coding gene Chr6:128456432-128469466 (+)
WSB/EiJ MGP_WSBEiJ_G0030490
protein coding gene Chr6:130731734-130745733 (+)



Homology
more
  • Human Ortholog
    FOXM1, forkhead box M1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXM1, forkhead box M1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TRIDENT
  • Links
    NCBI Gene ID: 2305
    neXtProt AC: NX_Q08050
    UniProt: Q08050

  • Chr Location
    12p13.33; chr12:2857681-2877155 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7318
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FOXM1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Foxm1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 3 alleles in 8 genetic backgrounds
    3 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardialdefects and polyploidy in heart and liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14235 NCBI Gene Model | MGI Sequence Detail 12893 C57BL/6J ±  kb
    transcript NM_008021 RefSeq | MGI Sequence Detail 4391 C57BL/6  
    polypeptide O08696 UniProt | EBI | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR018122 Fork head domain conserved site1
      IPR030456 Fork head domain conserved site 2
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 116
      Genomic 2
      cDNA 110
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141700, MGI:2141741, MGI:894699
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 49
      Diseases 3
      Gene Ontology 10
      Phenotypes 50
    • Earliest
      J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
    • Latest
      J:264706 Penke LR, et al., FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis. J Clin Invest. 2018 Jun 1;128(6):2389-2405

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory