About   Help   FAQ
Foxm1 Gene Detail
Summary
  • Symbol
    Foxm1
  • Name
    forkhead box M1
  • Synonyms
    Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347487
    NCBI Gene: 14235
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128339957-128352849 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347487
protein coding gene Chr6:128339930-128353109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031322
protein coding gene Chr6:131964112-131977230 (+)
A/J MGP_AJ_G0031293
protein coding gene Chr6:126906191-126919269 (+)
AKR/J MGP_AKRJ_G0031221
protein coding gene Chr6:130320924-130334079 (+)
BALB/cJ MGP_BALBcJ_G0031300
protein coding gene Chr6:126481510-126494633 (+)
C3H/HeJ MGP_C3HHeJ_G0031024
protein coding gene Chr6:130461905-130475065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031759
protein coding gene Chr6:135401074-135414276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028905
protein coding gene Chr6:124109715-124123041 (+)
CAST/EiJ MGP_CASTEiJ_G0030405
protein coding gene Chr6:130749763-130762913 (+)
CBA/J MGP_CBAJ_G0030985
protein coding gene Chr6:140627121-140640285 (+)
DBA/2J MGP_DBA2J_G0031141
protein coding gene Chr6:125799423-125812622 (+)
FVB/NJ MGP_FVBNJ_G0031091
protein coding gene Chr6:124729886-124743029 (+)
LP/J MGP_LPJ_G0031221
protein coding gene Chr6:132087665-132100824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031129
protein coding gene Chr6:144465651-144478784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031792
protein coding gene Chr6:130336814-130349972 (+)
PWK/PhJ MGP_PWKPhJ_G0030120
protein coding gene Chr6:124096683-124110120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029949
protein coding gene Chr6:128456432-128469466 (+)
WSB/EiJ MGP_WSBEiJ_G0030490
protein coding gene Chr6:130731734-130745733 (+)



Homology
more
  • Human Ortholog
    FOXM1, forkhead box M1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXM1, forkhead box M1
  • Synonyms
    FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TRIDENT
  • Links
    NCBI Gene ID: 2305
    neXtProt AC: NX_Q08050
    UniProt: Q08050

  • Chr Location
    12p13.33; chr12:2857680-2877174 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with Foxm1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 3 alleles in 8 genetic backgrounds
    3 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardialdefects and polyploidy in heart and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14235 NCBI Gene Model | MGI Sequence Detail 12893 C57BL/6J ±  kb
    transcript NM_008021 RefSeq | MGI Sequence Detail 4391 ZRU/MplStud  
    polypeptide O08696 UniProt | EBI | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      Genomic 2
      cDNA 110
      Primer pair 6
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141700, MGI:2141741, MGI:894699
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 66
      Diseases 3
      Gene Ontology 11
      Phenotypes 65
    • Earliest
      J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
    • Latest
      J:343539 Huang X, et al., Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury. Sci Transl Med. 2023 Aug 16;15(709):eabm5755

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory