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Foxm1 Gene Detail
Summary
  • Symbol
    Foxm1
  • Name
    forkhead box M1
  • Synonyms
    Fkh16, Foxm1b, HFH-11B, Mpm2, Trident, WIN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347487
    NCBI Gene: 14235
  • Gene Overview
    MyGene.info: FOXM1
Location & Maps
more
  • Sequence Map
    Chr6:128362967-128376146 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13180 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXM1, forkhead box M1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXM1, forkhead box M1
    Orthology source: HomoloGene
  • Synonyms
    FKHL16, FOXM1B, HFH11, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, MPP-2, PIG29, TRIDENT
  • Links
    NCBI Gene ID: 2305
    neXtProt AC: NX_Q08050

  • Chr Location
    12p13; chr12:2857681-2877155 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7318
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FOXM1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Foxm1 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Hepatocellular Carcinoma   OMIM: 114550 View 1 model
Lung Cancer   OMIM: 211980 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 3 alleles in 8 genetic backgrounds
    3 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in utero exhibiting reduced hepatoblast mitosis, impaired liver, bile duct and lung development, myocardial defects and ventricular hypoplasia. Most homozygotes for another null allele die perinatally with myocardialdefects and polyploidy in heart and liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023770 VEGA Gene Model | MGI Sequence Detail 13180 C57BL/6J ±  kb
transcript OTTMUST00000058073 VEGA | MGI Sequence Detail 4652 Not Applicable  
polypeptide OTTMUSP00000028087 VEGA | MGI Sequence Detail 757 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007635 forkhead box protein M1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 112
    Genomic 2
    cDNA 108
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:2141700, MGI:2141741, MGI:894699
References
more
  • Summaries
    All 111
    Developmental Gene Expression 41
    Diseases 3
    Gene Ontology 10
    Phenotypes 41
  • Earliest
    J:40543 Korver W, et al., The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 1;25(9):1715-9
  • Latest
    J:224892 Yan Y, et al., Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2. Nat Commun. 2015;6:7006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory