Foxf2
Gene Detail

Symbol Name ID

Foxf2 forkhead box F2 MGI:1347479

Synonyms

Fkh20, FREAC2, LUN

Feature Type

protein coding gene

Genetic Map

Chromosome 13

13.48 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:31625816-31631403 bp, + strand From VEGA annotation of GRCm38   5588 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1115  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: transcription factor HNF-3
Gene Tree: Foxf2

Human homologs

Human Homolog		FOXF2, forkhead box F2
NCBI Gene ID		2295
neXtProt AC		NX_Q12947
Human Synonyms		FKHL6, FREAC2, FREAC-2
Human Chr (Location)		6p25.3; chr6:1390069-1395832 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Chemically induced(1)
 

Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis.

 
Human Diseases Modeled Using Mouse Foxf2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	embryonic camera-type eye morphogenesis, embryonic digestive tract development, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (237)    Tissues (155)    Images (37)
Theiler Stages: 14, 15, 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	235
RT-PCR	2

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000735 (Evidence)
Ensembl Gene Model	ENSMUSG00000038402 (Evidence)
Entrez Gene	14238 (Evidence)
UniGene	125548
DFCI	TC1584141
DoTS	DT.60104659
Consensus CDS Project	CCDS26424.1
International Mouse Knockout Project Status	Foxf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000735	VEGA Gene Model | MGI Sequence Detail	5588	C57BL/6J
transcript	OTTMUST00000001381	VEGA | MGI Sequence Detail	2363	Not Applicable
polypeptide	OTTMUSP00000000656	VEGA | MGI Sequence Detail	446	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007622	forkhead box protein F2

References

(Earliest) J:50747 Pierrou S, et al., Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994 Oct 17;13(20):5002-12
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(50)

Other accession IDs

MGI:1298400