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Foxf2 Gene Detail
Summary
  • Symbol
    Foxf2
  • Name
    forkhead box F2
  • Synonyms
    Fkh20, FREAC2, LUN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347479
    NCBI Gene: 14238
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:31625816-31631403 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5588 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.48 cM, cytoband A4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FOXF2, forkhead box F2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXF2, forkhead box F2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL6, FREAC2, FREAC-2
  • Links
    NCBI Gene ID: 2295
    neXtProt AC: NX_Q12947
    UniProt: Q12947

  • Chr Location
    6p25.3; chr6:1389834-1395597 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000735 VEGA Gene Model | MGI Sequence Detail 5588 C57BL/6J ±  kb
    transcript OTTMUST00000001381 VEGA | MGI Sequence Detail 2363 Not Applicable  
    polypeptide OTTMUSP00000000656 VEGA | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 10
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1298400
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 27
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:244068 Bohnenpoll T, et al., A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development. PLoS Genet. 2017 Aug;13(8):e1006951

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory