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Foxf2
Gene Detail
Symbol

Name
ID
Foxf2
forkhead box F2
MGI:1347479
Synonyms
Fkh20, FREAC2, LUN
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.48 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:31625816-31631403 bp, + strand
From VEGA annotation of GRCm38

  5588 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1115  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXF2
Protein SuperFamily: transcription factor HNF-3
Gene Tree: Foxf2

Human
homologs
FOXF2, forkhead box F2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2295
neXtProt AC: NX_Q12947

Human Synonyms: FKHL6, FREAC2, FREAC-2

Human Chr (Location): 6p25.3; chr6:1389834-1395597 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5)
Genomic Mutations involving Foxf2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis.
 
Human Diseases Modeled in Mice Using Foxf2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Foxf2 interacts with 180 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (18 records)
Data Summary: Results (321)    Tissues (208)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 315
RT-PCR 6
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxf2 ; ZFIN foxf2a, foxf2b    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(9) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000735 (Evidence)
Ensembl Gene Model ENSMUSG00000038402 (Evidence)
Entrez Gene 14238 (Evidence)
UniGene 125548
DFCI TC1584141
DoTS DT.60104659
Consensus CDS Project CCDS26424.1
International Mouse Phenotyping Consortium Status Foxf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000735 VEGA Gene Model | MGI Sequence Detail 5588 C57BL/6J ±  kb
transcript OTTMUST00000001381 VEGA | MGI Sequence Detail 2363 Not Applicable 
polypeptide OTTMUSP00000000656 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007622 forkhead box protein F2
References
(Earliest) J:50747 Pierrou S, et al., Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994 Oct 17;13(20):5002-12
(Latest) J:203847 Hoggatt AM, et al., The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013 Oct 4;288(40):28477-87
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:1298400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory