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Foxf2 Gene Detail
Summary
  • Symbol
    Foxf2
  • Name
    forkhead box F2
  • Synonyms
    Fkh20, FREAC2, LUN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347479
    NCBI Gene: 14238
Location & Maps
more
  • Sequence Map
    Chr13:31625816-31631403 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5588 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.48 cM, cytoband A4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FOXF2, forkhead box F2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXF2, forkhead box F2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKHL6, FREAC2, FREAC-2
  • Links
    NCBI Gene ID: 2295
    neXtProt AC: NX_Q12947

  • Chr Location
    6p25.3; chr6:1389834-1395597 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Foxf2 mouse models

Human Disease Mouse Models
       Anterior Segment Mesenchymal Dysgenesis; ASMD   OMIM: 107250 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Foxf2
  • Incidental Mutations
Homozygous mutant mice do not live through the first day of life due to an inability to suckle, which is secondary to cleft palate and tongue abnormalities. Mice homozygous for an ENU mutation exhibit postnatal lethality without palate defect and abnormal anterior segment dysgenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000735 VEGA Gene Model | MGI Sequence Detail 5588 C57BL/6J ±  kb
transcript OTTMUST00000001381 VEGA | MGI Sequence Detail 2363 Not Applicable  
polypeptide OTTMUSP00000000656 VEGA | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 1
    cDNA 9
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1298400
References
more
  • Summaries
    All 52
    Developmental Gene Expression 23
    Diseases 1
    Gene Ontology 10
    Phenotypes 19
  • Earliest
    J:50747 Pierrou S, et al., Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994 Oct 17;13(20):5002-12
  • Latest
    J:234115 Nik AM, et al., Foxf2 is required for secondary palate development and Tgfbeta signaling in palatal shelf mesenchyme. Dev Biol. 2016 Jul 1;415(1):14-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory