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Foxa3 Gene Detail
Summary
  • Symbol
    Foxa3
  • Name
    forkhead box A3
  • Synonyms
    Hnf3g, Hnf-3g, Tcf3g, Tcf-3g
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347477
    NCBI Gene: 15377
  • Gene Overview
    MyGene.info: FOXA3
Location & Maps
more
  • Sequence Map
    Chr7:19013284-19023538 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10255 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FOXA3, forkhead box A3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FOXA3, forkhead box A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKHH3, HNF3G, TCF3G
  • Links
    NCBI Gene ID: 3171
    neXtProt AC: NX_P55318

  • Chr Location
    19q13.32; chr19:45864260-45873797 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Targeted
    3
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit reduced expression of several liver-specific and liver-enriched genes, but appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020440 VEGA Gene Model | MGI Sequence Detail 10255 C57BL/6J ±  kb
transcript OTTMUST00000048523 VEGA | MGI Sequence Detail 2037 Not Applicable  
polypeptide OTTMUSP00000022260 VEGA | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    72 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007604 hepatocyte nuclear factor 3-gamma
  • InterPro Domains
    IPR018533 Forkhead box protein, C-terminal
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR013638 Fork-head N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 32
    Genomic 5
    cDNA 24
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10806, MGD-MRK-14751, MGD-MRK-14757, MGD-MRK-16683, MGI:99888
References
more
  • Summaries
    All 72
    Developmental Gene Expression 23
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
  • Latest
    J:222254 Wangensteen KJ, et al., A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation. Genes Dev. 2015 May 1;29(9):904-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory