Foxa3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Foxa3
forkhead box A3
MGI:1347477

23 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Foxa3^tm1Khk/Foxa3^tm1Khk B6.129P2-Foxa3^tm1Khk	abnormal beige fat cell morphology	J:216477
	abnormal lipid homeostasis	J:216477
	abnormal primordial germ cell proliferation	J:134427
	abnormal seminiferous tubule epithelium morphology	J:134427
	abnormal Sertoli cell morphology	J:134427
	abnormal spermatogenesis	J:134427
	decreased body fat mass	J:216477
	decreased brown fat cell size	J:216477
	decreased circulating cholesterol level	J:216477
	decreased circulating leptin level	J:216477
	decreased fasting circulating glucose level	J:72595
	decreased hepatic glucose production	J:72595
	decreased susceptibility to weight gain	J:216477
	decreased testis weight	J:134427
	decreased white fat cell size	J:216477
	extended life span	J:216477
	increased adipocyte glucose uptake	J:216477
	increased insulin sensitivity	J:216477
	increased male germ cell apoptosis	J:134427
	increased oxygen consumption	J:216477
	reduced male fertility	J:134427
	seminiferous tubule degeneration	J:134427
Foxa3^tm1Khk/Foxa3^tm1Khk involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:48310

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23