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Foxa1
Gene Detail
 Symbol
Name
ID
Foxa1
forkhead box A1
MGI:1347472
Synonyms Hnf3a, Hnf-3a, Tcf3a, Tcf-3a
Feature Type protein coding gene
Genetic Map
Chromosome 12
24.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:57540631-57546121 bp, - strand
From NCBI annotation of GRCm38

  5491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: transcription factor HNF-3
Gene Tree: Foxa1

Human
homologs
Human Homolog FOXA1, forkhead box A1
NCBI Gene ID 3169
neXtProt AC  NX_P55317
Human Synonyms  HNF3A, TCF3A
Human Chr (Location)  14q12-q13; chr14:37589552-37595120 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit abnormal feeding, hypoglycemia, impaired glucagon secretion, hypotryglyceridemia, wasting, and lethality between postnatal days 2 and 14.
 
Interactions
Foxa1 interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process anatomical structure formation involved in morphogenesis, chromatin modification, ...
Component microvillus, nucleus, ...
Function DNA binding, DNA binding, bending, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (88 records)
Data Summary: Results (734)    Tissues (484)    Images (116)
Theiler Stages: 2, 3, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 139
RNA in situ 502
RT-PCR 68
RNase protection 25
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) Genomic(5) cDNA(39) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035451 (Evidence)
Entrez Gene15375 (Evidence)
UniGene4578
DFCITC1573059
DoTSDT.97358938
NIA Mouse Gene IndexU033976
Consensus CDS ProjectCCDS25926.1
International Mouse Knockout Project StatusFoxa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15375 NCBI Gene Model | MGI Sequence Detail 5491 C57BL/6J ±  kb
transcript NM_008259 RefSeq | MGI Sequence Detail 3188 C57BL/6 
polypeptide P35582 UniProt | EBI | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(12) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018533 Forkhead box protein, C-terminal
InterPro IPR013638 Fork-head N-terminal
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007602 hepatocyte nuclear factor 3-alpha
Graphical View of Protein Domain Structure
References (Earliest) J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
(Latest) J:199291 Jiang M, et al., Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep;140(17):3589-94
All references(156)
Other
accession IDs
MGD-MRK-10804, MGD-MRK-14749, MGD-MRK-14755, MGD-MRK-16685, MGI:99890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory