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Foxa1 Gene Detail
Summary
  • Symbol
    Foxa1
  • Name
    forkhead box A1
  • Synonyms
    Hnf3a, Hnf-3a, Tcf3a, Tcf-3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347472
    NCBI Gene: 15375
  • Gene Overview
    MyGene.info: FOXA1
Location & Maps
more
  • Sequence Map
    Chr12:57540631-57546121 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5491 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FOXA1, forkhead box A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXA1, forkhead box A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HNF3A, TCF3A
  • Links
    NCBI Gene ID: 3169
    neXtProt AC: NX_P55317

  • Chr Location
    14q21.1; chr14:37589552-37595120 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Foxa1
  • Incidental Mutations
    APF , CvDC
Homozygotes for targeted null mutations exhibit abnormal feeding, hypoglycemia, impaired glucagon secretion, hypotryglyceridemia, wasting, and lethality between postnatal days 2 and 14.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035451 Ensembl Gene Model | MGI Sequence Detail 5491 C57BL/6J ±  kb
transcript ENSMUST00000044380 Ensembl | MGI Sequence Detail 3188 Not Applicable  
polypeptide ENSMUSP00000041118 Ensembl | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007602 hepatocyte nuclear factor 3-alpha
  • InterPro Domains
    IPR018533 Forkhead box protein, C-terminal
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR013638 Fork-head N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 54
    Genomic 5
    cDNA 39
    Primer pair 9
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10804, MGD-MRK-14749, MGD-MRK-14755, MGD-MRK-16685, MGI:99890
References
more
  • Summaries
    All 160
    Developmental Gene Expression 95
    Gene Ontology 22
    Phenotypes 31
  • Earliest
    J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory