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Foxa1
Gene Detail
Symbol

Name
ID
Foxa1
forkhead box A1
MGI:1347472
Synonyms
Hnf3a, Hnf-3a, Tcf3a, Tcf-3a
Feature Type
protein coding gene
Genetic Map
Chromosome 12
24.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:57540631-57546121 bp, - strand
From Ensembl annotation of GRCm38

  5491 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXA1
Protein SuperFamily: transcription factor HNF-3
Gene Tree: Foxa1

Human
homologs
FOXA1, forkhead box A1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3169
neXtProt AC: NX_P55317

Human Synonyms: HNF3A, TCF3A

Human Chr (Location): 14q21.1; chr14:37589552-37595120 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted null mutations exhibit abnormal feeding, hypoglycemia, impaired glucagon secretion, hypotryglyceridemia, wasting, and lethality between postnatal days 2 and 14.
 
Interactions
Foxa1 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process anatomical structure formation involved in morphogenesis, chromatin modification, ...
Component microvillus, nucleolus, ...
Function DNA binding, double-stranded DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (93 records)
Data Summary: Results (734)    Tissues (496)    Images (116)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 139
RNA in situ 502
RT-PCR 68
RNase protection 25
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxa1 ; ZFIN foxa1    NEW 
Molecular
reagents
All nucleic(54) Genomic(5) cDNA(39) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000035451 (Evidence)
Entrez Gene 15375 (Evidence)
UniGene 4578
DFCI TC1573059
DoTS DT.97358938
NIA Mouse Gene Index U033976
Consensus CDS Project CCDS25926.1
International Mouse Phenotyping Consortium Status Foxa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035451 Ensembl Gene Model | MGI Sequence Detail 5491 C57BL/6J ±  kb
transcript ENSMUST00000044380 Ensembl | MGI Sequence Detail 3188 Not Applicable 
polypeptide ENSMUSP00000041118 Ensembl | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018533 Forkhead box protein, C-terminal
InterPro IPR013638 Fork-head N-terminal
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007602 hepatocyte nuclear factor 3-alpha
References
(Earliest) J:20860 Lai E, et al., Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 1991 Mar;5(3):416-27
(Latest) J:221106 Reddy OL, et al., Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer. Am J Pathol. 2015 May;185(5):1385-95
All references(160)
Other
accession IDs
MGD-MRK-10804, MGD-MRK-14749, MGD-MRK-14755, MGD-MRK-16685, MGI:99890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory