About   Help   FAQ
Homer2
Gene Detail
Symbol

Name
ID
Homer2
homer homolog 2 (Drosophila)
MGI:1347354
Synonyms
9330120H11Rik, CPD, Cupidin, Vesl-2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:81600481-81706925 bp, - strand
From NCBI annotation of GRCm38

  106445 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOMER2
Gene Tree: Homer2

Human
homologs
HOMER2, homer scaffolding protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9455
neXtProt AC: NX_Q9NSB8

Human Synonyms: ACPD, CPD, HOMER-2, VESL-2

Human Chr (Location): 15q24.3; chr15:82836946-82986161 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit an increase in intracellular calcium concentration and in the frequency of intracellular calcium oscillations in pancreatic acinar cells.
 
Interactions
Homer2 interacts with 560 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (150)    Tissues (42)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 105
Northern blot 8
Western blot 6
RT-PCR 26
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase homer2    NEW 
Molecular
reagents
All nucleic(85) cDNA(81) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000025813 (Evidence)
Entrez Gene 26557 (Evidence)
UniGene 228
DFCI TC1596409, TC1589253, TC1585109, TC1580770, TC1630616, TC1610736, TC1603711, TC1686163
DoTS DT.91446822, DT.94325924, DT.490590, DT.40154868, DT.111005514, DT.101707180, DT.101197127, DT.87052348, DT.91303631
NIA Mouse Gene Index U028784, U028783, U028785
PDB 1I7A
Consensus CDS Project CCDS40009.1, CCDS52284.1
International Mouse Phenotyping Consortium Status Homer2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26557 NCBI Gene Model | MGI Sequence Detail 106445 C57BL/6J ±  kb
transcript NM_011983 RefSeq | MGI Sequence Detail 10999 C57BL/6 
polypeptide Q9QWW1 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(1100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000008679 homer protein homolog 2
Graphical View of Protein Domain Structure
References
(Earliest) J:50718 Xiao B, et al., Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998 Oct;21(4):707-16
(Latest) J:216872 Yang YM, et al., Homer2 protein regulates plasma membrane Ca(2)(+)-ATPase-mediated Ca(2)(+) signaling in mouse parotid gland acinar cells. J Biol Chem. 2014 Sep 5;289(36):24971-9
All references(45)
Other
accession IDs
MGI:2142248, MGI:2442918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory