Hsf4
Gene Detail

Symbol Name ID

Hsf4 heat shock transcription factor 4 MGI:1347058

Synonyms

ldis1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.04 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:105269801-105275845 bp, + strand From VEGA annotation of GRCm38   6045 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100128  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hsf4

Human homologs

Human Homolog		HSF4, heat shock transcription factor 4
NCBI Gene ID		3299
neXtProt AC		NX_Q9ULV5
Human Synonyms		CTM
Human Chr (Location)		16q21; chr16:67197288-67203848 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HSF4

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Homozygous null mice display abnormal lens morphology and cataracts.

 
Human Diseases Modeled Using Mouse Hsf4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	camera-type eye development, cell development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (49)    Tissues (39)    Images (6)
Theiler Stages: 17, 21, 23, 26, 28

Assay Type	Results
RNA in situ	30
Western blot	9
RT-PCR	10

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000036906 (Evidence)
Ensembl Gene Model	ENSMUSG00000033249 (Evidence)
Entrez Gene	26386 (Evidence)
UniGene	89204
DFCI	TC1587029
DoTS	DT.94184183, DT.97361029, DT.97361030
NIA Mouse Gene Index	U009741
Consensus CDS Project	CCDS57638.1, CCDS57639.1, CCDS57640.1
International Mouse Knockout Project Status	Hsf4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036906	VEGA Gene Model | MGI Sequence Detail	6045	C57BL/6J
transcript	OTTMUST00000094818	VEGA | MGI Sequence Detail	1739	Not Applicable
polypeptide	OTTMUSP00000052844	VEGA | MGI Sequence Detail	492	Not Applicable

All sequences(61) RefSeq(7) UniProt(8)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000232	Heat shock factor (HSF)-type, DNA-binding
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000008793	heat shock factor protein 4

References

(Earliest) J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
(Latest) J:179658 Liang L, et al., Functional analysis of the Hsf4(lop11) allele responsible for cataracts in lop11 mice. Mol Vis. 2011;17:3062-71
All references(42)

Other accession IDs

MGI:3056558