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Hsf4 Gene Detail
Summary
  • Symbol
    Hsf4
  • Name
    heat shock transcription factor 4
  • Synonyms
    ldis1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347058
    NCBI Gene: 26386
  • Gene Overview
    MyGene.info: HSF4
Location & Maps
more
  • Sequence Map
    Chr8:105269801-105275845 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6045 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HSF4, heat shock transcription factor 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HSF4, heat shock transcription factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTM, CTRCT5
  • Links
    NCBI Gene ID: 3299
    neXtProt AC: NX_Q9ULV5

  • Chr Location
    16q21; chr16:67163385-67169945 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hsf4 mouse models; 1 with human HSF4 associations

Human Disease Mouse Models
       Cataract 5, Multiple Types; CTRCT5   OMIM: 116800 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Spontaneous
    1
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice display abnormal lens morphology and cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036906 VEGA Gene Model | MGI Sequence Detail 6045 C57BL/6J ±  kb
transcript OTTMUST00000094818 VEGA | MGI Sequence Detail 1739 Not Applicable  
polypeptide OTTMUSP00000052844 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    11 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008793 heat shock factor protein 4
  • InterPro Domains
    IPR000232 Heat shock factor (HSF)-type, DNA-binding
    IPR027723 Heat shock factor protein 4
    IPR027725 Heat shock transcription factor family
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:3056558
References
more
  • Summaries
    All 41
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory