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Hsf4
Gene Detail
Symbol

Name
ID
Hsf4
heat shock transcription factor 4
MGI:1347058
Synonyms
ldis1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105269801-105275845 bp, + strand
From VEGA annotation of GRCm38

  6045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100128  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HSF4
Gene Tree: Hsf4

Human
homologs
HSF4, heat shock transcription factor 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3299
neXtProt AC: NX_Q9ULV5

Human Synonyms: CTM, CTRCT5

Human Chr (Location): 16q21; chr16:67163385-67169945 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HSF4

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormal lens morphology and cataracts.
 
Human Diseases Modeled in Mice Using Hsf4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Hsf4 interacts with 139 markers (Mir24-1, Mir24-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process camera-type eye development, cell development, ...
Component nucleoplasm, nucleus
Function DNA binding, protein phosphatase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (49)    Tissues (41)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
Western blot 9
RT-PCR 10
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN hsf4    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036906 (Evidence)
Ensembl Gene Model ENSMUSG00000033249 (Evidence)
Entrez Gene 26386 (Evidence)
UniGene 89204
DFCI TC1587029
DoTS DT.97361030, DT.97361029, DT.94184183
NIA Mouse Gene Index U009741
Consensus CDS Project CCDS57638.1, CCDS57639.1, CCDS57640.1
International Mouse Phenotyping Consortium Status Hsf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036906 VEGA Gene Model | MGI Sequence Detail 6045 C57BL/6J ±  kb
transcript OTTMUST00000094818 VEGA | MGI Sequence Detail 1739 Not Applicable 
polypeptide OTTMUSP00000052844 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(17) UniProt(8)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008793 heat shock factor protein 4
References
(Earliest) J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
(Latest) J:205392 Jin X, et al., Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo. Mol Cancer Res. 2012 Apr;10(4):523-34
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:3056558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory