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Hsf4
Gene Detail
 Symbol
Name
ID
Hsf4
heat shock transcription factor 4
MGI:1347058
Synonyms ldis1
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.04 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105269801-105275845 bp, + strand
From VEGA annotation of GRCm38

  6045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100128  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hsf4

Human
homologs
Human Homolog HSF4, heat shock transcription factor 4
NCBI Gene ID 3299
neXtProt AC  NX_Q9ULV5
Human Synonyms  CTM, CTRCT5
Human Chr (Location)  16q21; chr16:67163385-67169945 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HSF4
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Spontaneous(1)
 
Homozygous null mice display abnormal lens morphology and cataracts.
 
Human Diseases Modeled Using Mouse Hsf4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process camera-type eye development, cell development, ...
Component nucleus
Function DNA binding, protein phosphatase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (49)    Tissues (39)    Images (6)
Theiler Stages: 17, 21, 23, 26, 28
Assay TypeResults
RNA in situ 30
Western blot 9
RT-PCR 10
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036906 (Evidence)
Ensembl Gene ModelENSMUSG00000033249 (Evidence)
Entrez Gene26386 (Evidence)
UniGene89204
DFCITC1587029
DoTSDT.94184183, DT.97361029, DT.97361030
NIA Mouse Gene IndexU009741
Consensus CDS ProjectCCDS57638.1, CCDS57639.1, CCDS57640.1
International Mouse Knockout Project StatusHsf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036906 VEGA Gene Model | MGI Sequence Detail 6045 C57BL/6J ±  kb
transcript OTTMUST00000094818 VEGA | MGI Sequence Detail 1739 Not Applicable 
polypeptide OTTMUSP00000052844 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(19) UniProt(8)
Polymorphisms SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000232 Heat shock factor (HSF)-type, DNA-binding
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000008793 heat shock factor protein 4
References (Earliest) J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
(Latest) J:205392 Jin X, et al., Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo. Mol Cancer Res. 2012 Apr;10(4):523-34
All references(44)
Other
accession IDs
MGI:3056558

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory