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Hsf4 Gene Detail
Summary
  • Symbol
    Hsf4
  • Name
    heat shock transcription factor 4
  • Synonyms
    ldis1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347058
    NCBI Gene: 26386
  • Gene Overview
    MyGene.info: HSF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:105269801-105275845 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6045 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HSF4, heat shock transcription factor 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HSF4, heat shock transcription factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTM, CTRCT5
  • Links
    NCBI Gene ID: 3299
    neXtProt AC: NX_Q9ULV5
    UniProt: Q9ULV5

  • Chr Location
    16q22.1; chr16:67163385-67169945 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hsf4 mouse models; 1 with human HSF4 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal lens morphology and cataracts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000036906 VEGA Gene Model | MGI Sequence Detail 6045 C57BL/6J ±  kb
    transcript OTTMUST00000094818 VEGA | MGI Sequence Detail 1739 Not Applicable  
    polypeptide OTTMUSP00000052844 VEGA | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      11 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008793 heat shock factor protein 4
    • InterPro Domains
      IPR000232 Heat shock factor (HSF)-type, DNA-binding
      IPR027725 Heat shock transcription factor family
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
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    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3056558
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
    • Latest
      J:249114 Cavalheiro GR, et al., N-myc regulates growth and fiber cell differentiation in lens development. Dev Biol. 2017 Sep 1;429(1):105-117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory