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Prnd Gene Detail
Summary
  • Symbol
    Prnd
  • Name
    prion protein dublet
  • Synonyms
    doppel, Dpl, prion protein-like protein, PrPLP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346999
    NCBI Gene: 26434
  • Member of
    Prn cluster
  • Gene Overview
    MyGene.info: PRND
Location & Maps
more
  • Sequence Map
    Chr2:131950861-131956130 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5270 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.07 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PRND, prion protein 2 (dublet)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRND, prion protein 2 (dublet)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ1068H6.4, DOPPEL, DPL, PrPLP
  • Links
    NCBI Gene ID: 23627
    neXtProt AC: NX_Q9UKY0

  • Chr Location
    20p13; chr20:4721854-4728462 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    2 involving Prnd
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014845 VEGA Gene Model | MGI Sequence Detail 5270 C57BL/6J ±  kb
transcript OTTMUST00000035255 VEGA | MGI Sequence Detail 1969 Not Applicable  
polypeptide OTTMUSP00000015756 VEGA | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • PDB
  • InterPro Domains
    IPR022416 Prion/Doppel protein, beta-ribbon domain
    IPR021566 Prion-like protein Doppel
Molecular
Reagents
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  • All nucleic 28
    Genomic 2
    cDNA 22
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138958
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:50880 Lee IY, et al., Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 1998 Oct;8(10):1022-37
  • Latest
    J:207227 Mercer RC, et al., The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27;288(52):37241-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory