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Prnd
Gene Detail
Symbol

Name
ID
Member of
Prnd
prion protein dublet
MGI:1346999
Prn cluster
Synonyms
doppel, Dpl, prion protein-like protein, PrPLP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
64.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:131950861-131956130 bp, + strand
From VEGA annotation of GRCm38

  5270 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8236  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRND
Gene Tree: Prnd

Human
homologs
PRND, prion protein 2 (dublet)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23627
neXtProt AC: NX_Q9UKY0

Human Synonyms: dJ1068H6.4, DOPPEL, DPL, PrPLP

Human Chr (Location): 20p13; chr20:4721854-4728462 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice display male infertility.
 
Interactions
Prnd interacts with 248 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cellular copper ion homeostasis, protein homooligomerization
Component anchored component of membrane, cell, ...
Function copper ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (90)    Tissues (13)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
Northern blot 7
Western blot 3
RT-PCR 15
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(22) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014845 (Evidence)
Ensembl Gene Model ENSMUSG00000027338 (Evidence)
Entrez Gene 26434 (Evidence)
UniGene 180750
DFCI TC1580591, TC1596329, TC1775044
DoTS DT.101178465, DT.101364928, DT.101364929, DT.97394597, DT.99840080
PDB 1I17, 1Z65
Consensus CDS Project CCDS16767.1
International Mouse Phenotyping Consortium Status Prnd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014845 VEGA Gene Model | MGI Sequence Detail 5270 C57BL/6J ±  kb
transcript OTTMUST00000035257 VEGA | MGI Sequence Detail 1938 Not Applicable 
polypeptide OTTMUSP00000015758 VEGA | MGI Sequence Detail 179 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022416 Prion/Doppel protein, beta-ribbon domain
InterPro IPR021566 Prion-like protein Doppel
Protein Ontology PR:000013259 prion-like protein doppel
References
(Earliest) J:50880 Lee IY, et al., Complete genomic sequence and analysis of the prion protein gene region from three mammalian species. Genome Res. 1998 Oct;8(10):1022-37
(Latest) J:207227 Mercer RC, et al., The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J Biol Chem. 2013 Dec 27;288(52):37241-55
All references(54)
Other
accession IDs
MGI:2138958

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory