About   Help   FAQ
Prnd Gene Detail
Summary
  • Symbol
    Prnd
  • Name
    prion like protein doppel
  • Synonyms
    doppel, Dpl, PrPLP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346999
    NCBI Gene: 26434
  • Member of
    Prn cluster
  • Gene Overview
    MyGene.info: PRND
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131950861-131956130 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346999
protein coding gene Chr2:131950861-131956131 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026536
protein coding gene Chr2:135505996-135511264 (+)
A/J MGP_AJ_G0026500
protein coding gene Chr2:129991674-129996944 (+)
AKR/J MGP_AKRJ_G0026475
protein coding gene Chr2:133728663-133733925 (+)
BALB/cJ MGP_BALBcJ_G0026512
protein coding gene Chr2:130384328-130389597 (+)
C3H/HeJ MGP_C3HHeJ_G0026255
protein coding gene Chr2:134195886-134201183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026957
protein coding gene Chr2:139636201-139642487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024334
protein coding gene Chr2:124723501-124728770 (+)
CAST/EiJ MGP_CASTEiJ_G0025716
protein coding gene Chr2:134506885-134512182 (+)
CBA/J MGP_CBAJ_G0026235
protein coding gene Chr2:144866230-144871498 (+)
DBA/2J MGP_DBA2J_G0026369
protein coding gene Chr2:129388223-129393489 (+)
FVB/NJ MGP_FVBNJ_G0026333
protein coding gene Chr2:128008892-128014233 (+)
LP/J MGP_LPJ_G0026474
protein coding gene Chr2:135714333-135719627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026353
protein coding gene Chr2:148662022-148667294 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027012
protein coding gene Chr2:133714067-133719335 (+)
PWK/PhJ MGP_PWKPhJ_G0025452
protein coding gene Chr2:128971683-128976941 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025254
protein coding gene Chr2:132864752-132870010 (+)
WSB/EiJ MGP_WSBEiJ_G0025790
protein coding gene Chr2:134634605-134639589 (+)



Homology
more
  • Human Ortholog
    PRND, prion like protein doppel
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRND, prion like protein doppel
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ1068H6.4, DOPPEL, DPL, PrPLP
  • Links
    NCBI Gene ID: 23627
    neXtProt AC: NX_Q9UKY0
    UniProt: Q9UKY0

  • Chr Location
    20p13; chr20:4721854-4728462 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027338 Ensembl Gene Model | MGI Sequence Detail 5270 C57BL/6J ±  kb
    transcript ENSMUST00000110170 Ensembl | MGI Sequence Detail 1969 Not Applicable  
    polypeptide ENSMUSP00000105799 Ensembl | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • PDB
    • InterPro Domains
      IPR036924 Prion/Doppel beta-ribbon domain superfamily
      IPR022416 Prion/Doppel protein, beta-ribbon domain
      IPR021566 Prion-like protein Doppel
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 23
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138958
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:218362 Mays CE, et al., Endoproteolytic processing of the mammalian prion glycoprotein family. FEBS J. 2014 Feb;281(3):862-76

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory