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Map4k1 Gene Detail
Summary
  • Symbol
    Map4k1
  • Name
    mitogen-activated protein kinase kinase kinase kinase 1
  • Synonyms
    Hpk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346882
    NCBI Gene: 26411
  • Gene Overview
    MyGene.info: MAP4K1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28982050-29003279 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346882
protein coding gene Chr7:28982050-29003279 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031969
protein coding gene Chr7:27870869-27895379 (+)
A/J MGP_AJ_G0031947
protein coding gene Chr7:27140703-27161577 (+)
AKR/J MGP_AKRJ_G0031879
protein coding gene Chr7:27841980-27867177 (+)
BALB/cJ MGP_BALBcJ_G0031954
protein coding gene Chr7:27293881-27317808 (+)
C3H/HeJ MGP_C3HHeJ_G0031673
protein coding gene Chr7:28245807-28266065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032418
protein coding gene Chr7:28755039-28775171 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029470
protein coding gene Chr7:28201112-28221473 (+)
CAST/EiJ MGP_CASTEiJ_G0031008
protein coding gene Chr7:21538815-21561136 (+)
CBA/J MGP_CBAJ_G0031639
protein coding gene Chr7:30108271-30133662 (+)
DBA/2J MGP_DBA2J_G0031791
protein coding gene Chr7:26886070-26906607 (+)
FVB/NJ MGP_FVBNJ_G0031748
protein coding gene Chr7:26975497-26997685 (+)
LP/J MGP_LPJ_G0031871
protein coding gene Chr7:28170339-28191838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031784
protein coding gene Chr7:29494170-29517218 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032448
protein coding gene Chr7:27325955-27345758 (+)
PWK/PhJ MGP_PWKPhJ_G0030733
protein coding gene Chr7:21924029-21945000 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030566
protein coding gene Chr7:18349767-18373576 (+)
WSB/EiJ MGP_WSBEiJ_G0031117
protein coding gene Chr7:27700749-27722603 (+)



Homology
more
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HPK1
  • Links
    NCBI Gene ID: 11184
    neXtProt AC: NX_Q92918
    UniProt: Q92918

  • Chr Location
    19q13.2; chr19:38587640-38618035 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26411 NCBI Gene Model | MGI Sequence Detail 21230 C57BL/6J ±  kb
transcript NM_001355054 RefSeq | MGI Sequence Detail 2723 C57BL/6  
polypeptide P70218 UniProt | EBI | MGI Sequence Detail 827 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38203, MGI:109159
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
  • Latest
    J:197557 Jakob SM, et al., Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood. 2013 May 16;121(20):4184-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory