Map4k1 MGI Mouse Gene Detail - MGI:1346882 - mitogen-activated protein kinase kinase kinase kinase 1

Symbol

Map4k1
Name

mitogen-activated protein kinase kinase kinase kinase 1
Synonyms

Hpk1

Feature Type

protein coding gene
IDs

MGI:1346882
NCBI Gene: 26411
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:28681506-28702704 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

696 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346882	protein coding gene	Chr7:28681475-28702704 (+)
129S1/SvImJ	ENSMUSG00200042704	protein coding gene	Chr7:18481519-18502735 (+)
A/J	ENSMUSG00195042794	protein coding gene	Chr7:21148283-21169504 (+)
AKR/J	ENSMUSG00220048889	protein coding gene	Chr7:23323822-23345058 (-)
BALB/cJ	ENSMUSG00180051069	protein coding gene	Chr7:19207813-19229031 (+)
C3H/HeJ	ENSMUSG00175030197	protein coding gene	Chr7:20247196-20268411 (+)
C57BL/6NJ	ENSMUSG00215053926	protein coding gene	Chr7:18371468-18392704 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029470	protein coding gene	Chr7:28201112-28221473 (+)
CAST/EiJ	ENSTCUG00005047760	protein coding gene	Chr7:20188812-20210300 (+)
CBA/J	ENSMUSG00210052980	protein coding gene	Chr7:19431736-19452950 (+)
DBA/2J	ENSMUSG00185043965	protein coding gene	Chr7:22533068-22554302 (+)
FVB/NJ	ENSMUSG00205045198	protein coding gene	Chr7:19213927-19235131 (+)
JF1/MsJ	ENSUMUG00000048310	protein coding gene	Chr7:26948492-26969899 (+)
LP/J	ENSMUSG00230052949	protein coding gene	Chr7:27703588-27724817 (+)
NOD/ShiLtJ	ENSMUSG00190036898	protein coding gene	Chr7:18867327-18888560 (+)
NZO/HlLtJ	ENSMUSG00225026568	protein coding gene	Chr7:26546732-26567964 (+)
PWK/PhJ	ENSLUMG00010045010	protein coding gene	Chr7:18913411-18934679 (+)
SPRET/EiJ	ENSMSPG00010047601	protein coding gene	Chr7:18257314-18278560 (+)
WSB/EiJ	ENSIUOG00005053387	protein coding gene	Chr7:13137198-13158509 (+)

Human Ortholog

MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
Synonyms

HPK1
Links

HGNC:6863

NCBI Gene ID: 11184

UniProt: Q92918
Chr Location

19q13.2; chr19:38587641-38619161 (-) GRCh38

MGI Vertebrate Homology

Map4k1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP4K1
Protein SuperFamily

MAPKKKK
Gene Tree

Map4k1

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Phenotype Summary

11 phenotypes from 3 alleles in 4 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

14
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.

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All GO Annotations

36
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

143
cDNA Data

38
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

16
UniProt

5
CCDS

CCDS39865.1, CCDS90193.1

Ensembl

ENSMUSG00000037337 (Evidence)
NCBI Gene

26411

			Length	Strain/Species	Flank
genomic	26411	NCBI Gene Model \| MGI Sequence Detail	21199	C57BL/6J	± kb
transcript	NM_008279	RefSeq \| MGI Sequence Detail	2700	C57BL/6
polypeptide	P70218	UniProt \| EBI \| MGI Sequence Detail	827	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010143 mitogen-activated protein kinase kinase kinase kinase 1

(term hierarchy)
PDB

1UTI
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase
GlyGen

P70218 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 2

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MGD-MRK-38203, MGI:109159

Summaries

All 53

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 17
Earliest

J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
Latest

J:360670 Choi WS, et al., HPK1 Dysregulation-Associated NK Cell Dysfunction and Defective Expansion Promotes Metastatic Melanoma Progression. Adv Sci (Weinh). 2024 Aug;11(29):e2400920

TSS for Map4k1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65584	Chr7:28682257-28682317 (+)	781 bp
Tssr65585	Chr7:28682335-28682346 (+)	835 bp
Tssr65586	Chr7:28684154-28684155 (+)	2,649 bp
Tssr65587	Chr7:28700209-28700247 (+)	18,722 bp
Tssr65588	Chr7:28700248-28700262 (+)	18,749 bp
Tssr65589	Chr7:28700940-28700957 (+)	19,443 bp
Tssr65590	Chr7:28700959-28700977 (+)	19,462 bp
Tssr65591	Chr7:28700991-28701016 (+)	19,498 bp
Tssr65592	Chr7:28701023-28701050 (+)	19,531 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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