Map4k1 MGI Mouse Gene Detail - MGI:1346882 - mitogen-activated protein kinase kinase kinase kinase 1

Symbol

Map4k1
Name

mitogen-activated protein kinase kinase kinase kinase 1
Synonyms

Hpk1

Feature Type

protein coding gene
IDs

MGI:1346882
NCBI Gene: 26411
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:28681475-28702704 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.94 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

137 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346882	protein coding gene	Chr7:28681475-28702704 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031969	protein coding gene	Chr7:27870869-27895379 (+)
A/J	MGP_AJ_G0031947	protein coding gene	Chr7:27140703-27161577 (+)
AKR/J	MGP_AKRJ_G0031879	protein coding gene	Chr7:27841980-27867177 (+)
BALB/cJ	MGP_BALBcJ_G0031954	protein coding gene	Chr7:27293881-27317808 (+)
C3H/HeJ	MGP_C3HHeJ_G0031673	protein coding gene	Chr7:28245807-28266065 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032418	protein coding gene	Chr7:28755039-28775171 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029470	protein coding gene	Chr7:28201112-28221473 (+)
CAST/EiJ	MGP_CASTEiJ_G0031008	protein coding gene	Chr7:21538815-21561136 (+)
CBA/J	MGP_CBAJ_G0031639	protein coding gene	Chr7:30108271-30133662 (+)
DBA/2J	MGP_DBA2J_G0031791	protein coding gene	Chr7:26886070-26906607 (+)
FVB/NJ	MGP_FVBNJ_G0031748	protein coding gene	Chr7:26975497-26997685 (+)
LP/J	MGP_LPJ_G0031871	protein coding gene	Chr7:28170339-28191838 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031784	protein coding gene	Chr7:29494170-29517218 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032448	protein coding gene	Chr7:27325955-27345758 (+)
PWK/PhJ	MGP_PWKPhJ_G0030733	protein coding gene	Chr7:21924029-21945000 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030566	protein coding gene	Chr7:18349767-18373576 (+)
WSB/EiJ	MGP_WSBEiJ_G0031117	protein coding gene	Chr7:27700749-27722603 (+)

Human Ortholog

MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
Synonyms

HPK1
Links

HGNC:6863

NCBI Gene ID: 11184

neXtProt AC: NX_Q92918

UniProt: Q92918
Chr Location

19q13.2; chr19:38587641-38618882 (-) GRCh38

MGI Vertebrate Homology

Map4k1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MAP4K1
Protein SuperFamily

MAPKKKK
Gene Tree

Map4k1

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Phenotype Summary

11 phenotypes from 3 alleles in 4 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

14
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available

Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

862
Tissues

143
cDNA Data

38
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

16
UniProt

4
CCDS

CCDS39865.1, CCDS90193.1

Ensembl

ENSMUSG00000037337 (Evidence)
NCBI Gene

26411

			Length	Strain/Species	Flank
genomic	26411	NCBI Gene Model \| MGI Sequence Detail	21230	C57BL/6J	± kb
transcript	NM_008279	RefSeq \| MGI Sequence Detail	2700	C57BL/6
polypeptide	P70218	UniProt \| EBI \| MGI Sequence Detail	827	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010143 mitogen-activated protein kinase kinase kinase kinase 1

(term hierarchy)
PDB

1UTI
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 2

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MGD-MRK-38203, MGI:109159

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 16
Earliest

J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Map4k1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65584	Chr7:28682257-28682317 (+)	812 bp
Tssr65585	Chr7:28682335-28682346 (+)	866 bp
Tssr65586	Chr7:28684154-28684155 (+)	2,680 bp
Tssr65587	Chr7:28700209-28700247 (+)	18,753 bp
Tssr65588	Chr7:28700248-28700262 (+)	18,780 bp
Tssr65589	Chr7:28700940-28700957 (+)	19,474 bp
Tssr65590	Chr7:28700959-28700977 (+)	19,493 bp
Tssr65591	Chr7:28700991-28701016 (+)	19,529 bp
Tssr65592	Chr7:28701023-28701050 (+)	19,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23