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Map4k1
Gene Detail
 Symbol
Name
ID
Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
MGI:1346882
Synonyms Hpk1
Feature Type protein coding gene
Genetic Map
Chromosome 7
16.94 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28982854-29003279 bp, + strand
From NCBI annotation of GRCm38

  20426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: mitogen-activated protein kinase kinase kinase kinase
Gene Tree: Map4k1

Human
homologs
Human Homolog MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
NCBI Gene ID 11184
neXtProt AC  NX_Q92918
Human Synonyms  HPK1
Human Chr (Location)  19q13.1-q13.4; chr19:38587640-38618035 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(1) Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.
 
Interactions
Map4k1 interacts with 34 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process activation of MAPKKK activity, cell proliferation, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (156)    Tissues (143)    Images (7)
Theiler Stages: 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 123
Northern blot 33
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000037337 (Evidence)
Entrez Gene26411 (Evidence)
UniGene148278
DFCITC1581150, TC1596168
DoTSDT.40173067, DT.97400725, DT.97400726
NIA Mouse Gene IndexU007895
EC2.7.11.1
PDB1UTI
Consensus CDS ProjectCCDS39865.1
International Mouse Knockout Project StatusMap4k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26411 NCBI Gene Model | MGI Sequence Detail 20426 C57BL/6J ±  kb
transcript NM_008279 RefSeq | MGI Sequence Detail 2699 Not Specified 
polypeptide P70218 UniProt | EBI | MGI Sequence Detail 827 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(133 from dbSNP Build 137)    SNPs within 2kb including multiple locations(135)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010143 mitogen-activated protein kinase kinase kinase kinase 1
Graphical View of Protein Domain Structure
References (Earliest) J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
(Latest) J:197557 Jakob SM, et al., Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood. 2013 May 16;121(20):4184-94
All references(41)
Other
accession IDs
MGD-MRK-38203, MGI:109159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory