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Map4k1
Gene Detail
Symbol

Name
ID
Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
MGI:1346882
Synonyms
Hpk1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.94 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28982854-29003279 bp, + strand
From Ensembl annotation of GRCm38

  20426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: MAP4K1
Protein SuperFamily: mitogen-activated protein kinase kinase kinase kinase
Gene Tree: Map4k1

Human
homologs
MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11184
neXtProt AC: NX_Q92918

Human Synonyms: HPK1

Human Chr (Location): 19q13.1-q13.4; chr19:38587640-38618035 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(1) Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.
 
Interactions
Map4k1 interacts with 34 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPKKK activity, activation of protein kinase activity, ...
Component cytoplasm, intracellular, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (156)    Tissues (143)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
Northern blot 33
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037337 (Evidence)
Entrez Gene 26411 (Evidence)
UniGene 148278
DFCI TC1581150, TC1596168
DoTS DT.40173067, DT.97400725, DT.97400726
NIA Mouse Gene Index U007895
EC 2.7.11.1
PDB 1UTI
Consensus CDS Project CCDS39865.1
International Mouse Phenotyping Consortium Status Map4k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037337 Ensembl Gene Model | MGI Sequence Detail 20426 C57BL/6J ±  kb
transcript ENSMUST00000085835 Ensembl | MGI Sequence Detail 2699 Not Applicable 
polypeptide ENSMUSP00000082995 Ensembl | MGI Sequence Detail 827 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)    SNPs within 2kb including multiple locations(135)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron homology (CNH) domain
InterPro IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
Protein Ontology PR:000010143 mitogen-activated protein kinase kinase kinase kinase 1
References
(Earliest) J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
(Latest) J:197557 Jakob SM, et al., Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood. 2013 May 16;121(20):4184-94
All references(40)
Other
accession IDs
MGD-MRK-38203, MGI:109159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory