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Map4k1 Gene Detail
Summary
  • Symbol
    Map4k1
  • Name
    mitogen-activated protein kinase kinase kinase kinase 1
  • Synonyms
    Hpk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346882
    NCBI Gene: 26411
  • Gene Overview
    MyGene.info: MAP4K1
Location & Maps
more
  • Sequence Map
    Chr7:28982050-29003279 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21230 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP4K1, mitogen-activated protein kinase kinase kinase kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPK1
  • Links
    NCBI Gene ID: 11184
    neXtProt AC: NX_Q92918

  • Chr Location
    19q13.1-q13.4; chr19:38587640-38618035 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    1
  • Gene trapped
    17
  • Targeted
    2
  • Incidental Mutations
Homozygous null mice have increased responses of B and T cells. Dendritic cells are also hyperresponsive to stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059210 VEGA Gene Model | MGI Sequence Detail 21230 C57BL/6J ±  kb
transcript OTTMUST00000145293 VEGA | MGI Sequence Detail 2724 Not Applicable  
polypeptide OTTMUSP00000075712 VEGA | MGI Sequence Detail 827 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010143 mitogen-activated protein kinase kinase kinase kinase 1
  • PDB
  • EC
  • InterPro Domains
    IPR001180 Citron homology (CNH) domain
    IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
Molecular
Reagents
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  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-38203, MGI:109159
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
  • Latest
    J:197557 Jakob SM, et al., Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response. Blood. 2013 May 16;121(20):4184-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory