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Map3k1
Gene Detail
 Symbol
Name
ID
Map3k1
mitogen-activated protein kinase kinase kinase 1
MGI:1346872
Synonyms lg, Mekk, MEKK1
Feature Type protein coding gene
Genetic Map
Chromosome 13
63.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:111746428-111808993 bp, - strand
From VEGA annotation of GRCm38

  62566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Map3k1

Human
homologs
Human Homolog MAP3K1, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
NCBI Gene ID 4214
neXtProt AC  NX_Q13233
Human Synonyms  MAPKKK1, MEKK, MEKK1, MEKK 1, SRXY6
Human Chr (Location)  5q11.2; chr5:56815073-56896152 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MAP3K1
Alleles
and
phenotypes
All alleles(10) : Targeted(4) Gene trapped(5) Spontaneous(1)
 
Mice homozygous for a spontaneous allele are born with one or both eyes open. Mice homozygous for a knock-out allele are born with open eyes and exhibit increased response to aortic banding and blood vessel healing.
 
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process activation of JNKK activity, activation of JUN kinase activity, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, JUN kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (226)    Tissues (64)    Images (25)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 88
RT-PCR 138
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(5) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020184 (Evidence)
Ensembl Gene ModelENSMUSG00000021754 (Evidence)
Entrez Gene26401 (Evidence)
DFCITC1582283
DoTSDT.101717988, DT.533482, DT.97343713
EC2.7.11.25
Consensus CDS ProjectCCDS26771.1
International Mouse Knockout Project StatusMap3k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020184 VEGA Gene Model | MGI Sequence Detail 62566 C57BL/6J ±  kb
transcript OTTMUST00000047959 VEGA | MGI Sequence Detail 6978 Not Applicable 
polypeptide OTTMUSP00000021865 VEGA | MGI Sequence Detail 1493 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(10) UniProt(3)
Polymorphisms PCR(2) : SNPs within 2kb(950 from dbSNP Build 137)    SNPs within 2kb including multiple locations(952)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR007527 Zinc finger, SWIM-type
Protein Ontology PR:000003215 mitogen-activated protein kinase kinase kinase 1
References (Earliest) J:5056 Ricardo NS, et al., Further observations on lg MI (lid-gap Miller) and other ope1-eye mutants in the house mouse. Can J Genet Cytol. 1967 Sep;9(3):596-605
(Latest) J:197599 Pitetti JL, et al., Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
All references(85)
Other
accession IDs
MGD-MRK-28141, MGI:104845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory