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Map3k1
Gene Detail
Symbol

Name
ID
Map3k1
mitogen-activated protein kinase kinase kinase 1
MGI:1346872
Synonyms
lg, Mekk, MEKK1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
63.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:111746428-111808993 bp, - strand
From VEGA annotation of GRCm38

  62566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8056  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAP3K1
Gene Tree: Map3k1

Human
homologs
MAP3K1, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4214
neXtProt AC: NX_Q13233

Human Synonyms: MAPKKK1, MEKK, MEKK1, MEKK 1, SRXY6

Human Chr (Location): 5q11.2; chr5:56815073-56896152 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAP3K1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a spontaneous allele are born with one or both eyes open. Mice homozygous for a knock-out allele are born with open eyes and exhibit increased response to aortic banding and blood vessel healing.
 
Interactions
Map3k1 interacts with 418 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process activation of JNKK activity, activation of JUN kinase activity, ...
Component cell junction, cytoplasm, ...
Function ATP binding, JUN kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (226)    Tissues (64)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 88
RT-PCR 138
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase map3k1    NEW 
Molecular
reagents
All nucleic(10) Genomic(1) cDNA(5) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020184 (Evidence)
Ensembl Gene Model ENSMUSG00000021754 (Evidence)
Entrez Gene 26401 (Evidence)
DFCI TC1582283
DoTS DT.101717988, DT.97343713, DT.533482
EC 2.7.11.25
Consensus CDS Project CCDS26771.1
International Mouse Phenotyping Consortium Status Map3k1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020184 VEGA Gene Model | MGI Sequence Detail 62566 C57BL/6J ±  kb
transcript OTTMUST00000047959 VEGA | MGI Sequence Detail 6978 Not Applicable 
polypeptide OTTMUSP00000021865 VEGA | MGI Sequence Detail 1493 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(3)
Polymorphisms
PCR(2) : SNPs within 2kb(950 from dbSNP Build 137)    SNPs within 2kb including multiple locations(952)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR007527 Zinc finger, SWIM-type
Protein Ontology PR:000003215 mitogen-activated protein kinase kinase kinase 1
References
(Earliest) J:5056 Ricardo NS, et al., Further observations on lg MI (lid-gap Miller) and other ope1-eye mutants in the house mouse. Can J Genet Cytol. 1967 Sep;9(3):596-605
(Latest) J:216505 Meng Q, et al., Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Dev Biol. 2014 Nov 1;395(1):29-37
All references(88)
Other
accession IDs
MGD-MRK-28141, MGI:104845

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory