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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Map3k1
mitogen-activated protein kinase kinase kinase 1
MGI:1346872
54 phenotypes from 5 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Map3k1Ga/Map3k1Ga
involves: BALB/cGa
abnormal eyelid development J:95944
corneal opacity J:95944
eyelids open at birth J:95944
Map3k1goya/Map3k1+
involves: C3H * C57BL/6J
increased cochlear outer hair cell number J:226897
Map3k1goya/Map3k1goya
involves: C3H * C57BL/6J
abnormal eye morphology J:226897
abnormal eye physiology J:226897
abnormal pinna reflex J:226897
abnormal retina layer morphology J:226897
cochlear outer hair cell degeneration J:226897
deafness J:226897
early eyelid opening J:226897
exophthalmos J:226897
normal hearing/vestibular/ear phenotype J:226897
increased cochlear outer hair cell number J:226897
increased or absent threshold for auditory brainstem response J:226897
microphthalmia J:226897
organ of Corti degeneration J:226897
Map3k1goya/Map3k1tm1Yxia
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
deafness J:226897
increased or absent threshold for auditory brainstem response J:226897
Map3k1tm1a(KOMP)Wtsi/Map3k1+
C57BL/6N-Map3k1tm1a(KOMP)Wtsi/Wtsi
abnormal retina morphology J:211773
decreased circulating fructosamine level J:211773
decreased fasting circulating glucose level J:211773
increased bone mineral content J:211773
increased circulating free fatty acids level J:211773
increased lean body mass J:211773
increased red blood cell distribution width J:211773
Map3k1tm1a(KOMP)Wtsi/Map3k1tm1a(KOMP)Wtsi
C57BL/6N-Map3k1tm1a(KOMP)Wtsi/Wtsi
preweaning lethality, incomplete penetrance J:211773
Map3k1tm1Glj/Map3k1tm1Glj
involves: 129S/SvEv
abnormal eyelid development J:62909
abnormal heart left ventricle morphology J:78068
abnormal vascular smooth muscle physiology J:108989
abnormal vascular wound healing J:108989
congestive heart failure J:78068
decreased ventricle muscle contractility J:78068
eyelids open at birth J:62909
heart inflammation J:78068
normal immune system phenotype J:62909
impaired fibroblast cell migration J:62909
increased cardiomyocyte apoptosis J:78068
increased response of heart to induced stress J:78068
increased susceptibility to induced morbidity/mortality J:78068
Map3k1tm1Yxia/Map3k1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
increased cochlear outer hair cell number J:226897
Map3k1tm1Yxia/Map3k1tm1Yxia
involves: 129/Sv * C57BL/6
abnormal eyelid development J:85346
abnormal eyelid fusion J:85346
abnormal eyelid margin morphology J:85346
abnormal eyelid morphology J:85346
abnormal keratinocyte morphology J:85346
eyelids open at birth J:85346
Map3k1tm1Yxia/Map3k1tm1Yxia
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
cochlear outer hair cell degeneration J:226897
deafness J:226897
decreased cochlear inner hair cell number J:226897
increased cochlear outer hair cell number J:226897
increased or absent threshold for auditory brainstem response J:226897
organ of Corti degeneration J:226897
Map3k1tm1Yxia/Map3k1tm1Yxia
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal cornea morphology J:176244
abnormal corneal stroma morphology J:176244
abnormal iris morphology J:176244
abnormal Muller cell morphology J:176244
abnormal retina development J:176244
abnormal retina morphology J:176244
abnormal retina outer nuclear layer morphology J:176244
abnormal retina pigment epithelium morphology J:176244
corneal opacity J:176244
early eyelid opening J:176244
increased corneal stroma thickness J:176244
increased retina apoptosis J:176244
retina degeneration J:176244
retina gliosis J:176244
retina neovascularization J:176244
retina photoreceptor degeneration J:176244
thin retina outer nuclear layer J:176244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory