Map3k1^goya
Chemically induced Allele Detail

Summary

• Symbol: Map3k1^goya
• Name: mitogen-activated protein kinase kinase kinase 1; goya
• MGI ID: MGI:5502228
• Gene: Map3k1 Location: Chr13:111882962-111945527 bp, - strand Genetic Position: Chr13, 63.36 cM
• Alliance: Map3k1^goya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU induced a point mutation of T to C in intron 13 at the splice donor site. RT-PCR confirmed the absence of full-length transcript and production of two smaller products. The predicted truncated protein would lack the C-terminal 770 amino acids, including the kinase domain. (J:226897)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k1 Mutation: 62 strains or lines available

References

• Original: J:226897 Parker A, et al., The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells. Dis Model Mech. 2015 Dec 1;8(12):1555-68
• All: 1 reference(s)