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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k1goya
goya
MGI:5502228
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k1goya/Map3k1goya involves: C3H * C57BL/6J MGI:5699111
ht2
 		Map3k1goya/Map3k1+ involves: C3H * C57BL/6J MGI:5699112
ht3
 		Map3k1goya/Map3k1tm1Yxia involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5699115


Genotype
MGI:5699111
hm1
Allelic
Composition		 Map3k1goya/Map3k1goya
Genetic
Background		 involves: C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1goya mutation (0 available); any Map3k1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:226897 )
N
• mice exhibit normal vestibular function, Reissner's membrane, stria vascularis and strial ganglion neurons, middle ear morphology and inner hair cells
cochlear outer hair cell degeneration ( J:226897 )
• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
organ of Corti degeneration ( J:226897 )
• cellular degeneration at 9 weeks
increased or absent threshold for auditory brainstem response ( J:226897 )
• at 2 weeks in only the highest frequency
• at 4 and 9 weeks of age
• however, no further decline is observed between 9 week and 1 year

vision/eye
abnormal eye morphology ( J:226897 )
• highly variable eye pathology ranging from microphthalmia to normal eyes to bulging eyes
• however, retinal pigment epithelium appears normal at P0
exophthalmos ( J:226897 )
• in some mice
microphthalmia ( J:226897 )
• in some mice
early eyelid opening ( J:226897 )
• eyes are open at birth
abnormal eye physiology ( J:226897 )
• mice fail to respond in an optokinetic drum visual-function assay

behavior/neurological
abnormal pinna reflex ( J:226897 )
• reduced Preyers response to a click-box auditory stimulus

nervous system
cochlear outer hair cell degeneration ( J:226897 )
• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks




Genotype
MGI:5699112
ht2
Allelic
Composition		 Map3k1goya/Map3k1+
Genetic
Background		 involves: C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1goya mutation (0 available); any Map3k1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased cochlear outer hair cell number ( J:226897 )
• however, mice do not exhibit increased susceptibility to age-related hearing loss or outer hair cell degeneration

nervous system
increased cochlear outer hair cell number ( J:226897 )
• however, mice do not exhibit increased susceptibility to age-related hearing loss or outer hair cell degeneration




Genotype
MGI:5699115
ht3
Allelic
Composition		 Map3k1goya/Map3k1tm1Yxia
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1goya mutation (0 available); any Map3k1 mutation (62 available)
Map3k1tm1Yxia mutation (0 available); any Map3k1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:226897 )
• at 9 weeks of age with an apical-to-basal gradient




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory