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Mapk10
Gene Detail
Symbol

Name
ID
Mapk10
mitogen-activated protein kinase 10
MGI:1346863
Synonyms
C230008H04Rik, JNK3, p493F12, Serk2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
49.61 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:102912354-103211334 bp, - strand
From VEGA annotation of GRCm38

  298981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk10

Human
homologs
Human Homolog MAPK10, mitogen-activated protein kinase 10
NCBI Gene ID 5602
neXtProt AC  NX_P53779
Human Synonyms  JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b
Human Chr (Location)  4q22.1-q23; chr4:86012299-86453130 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.
 
Interactions
Mapk10 interacts with 448 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process JNK cascade, JUN phosphorylation, ...
Component cytoplasm, intracellular, ...
Function ATP binding, JUN kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (245)    Tissues (130)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 245
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016343 (Evidence)
Ensembl Gene ModelENSMUSG00000046709 (Evidence)
Entrez Gene26414 (Evidence)
DFCITC1576592, TC1590141, TC1599958, TC1599083, TC1597854, TC1590474
DoTSDT.529797, DT.101735368, DT.110648893, DT.101391873, DT.101197129, DT.94150758, DT.97362725
NIA Mouse Gene IndexU081043
EC2.7.11.24
Consensus CDS ProjectCCDS39185.1, CCDS51574.1
International Mouse Knockout Project StatusMapk10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016343 VEGA Gene Model | MGI Sequence Detail 298981 C57BL/6J ±  kb
transcript OTTMUST00000039290 VEGA | MGI Sequence Detail 2357 Not Applicable 
polypeptide OTTMUSP00000017557 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(24) UniProt(17)
Polymorphisms
SNPs within 2kb(1754 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010151 mitogen-activated protein kinase 10
References
(Earliest) J:30685 Suzuki J, et al., Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res. 1995 Nov;23(4):345-51
(Latest) J:214369 Fernandes KA, et al., DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis. 2014 Sep;69:108-16
All references(85)
Other
accession IDs
MGD-MRK-36125, MGI:107554, MGI:2442453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory