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Mapk10
Gene Detail
Symbol

Name
ID
Mapk10
mitogen-activated protein kinase 10
MGI:1346863
Synonyms
C230008H04Rik, JNK3, p493F12, Serk2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
49.61 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:102912354-103211334 bp, - strand
From VEGA annotation of GRCm38

  298981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK10
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk10

Human
homologs
MAPK10, mitogen-activated protein kinase 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5602
neXtProt AC: NX_P53779

Human Synonyms: JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b

Human Chr (Location): 4q22.1-q23; chr4:86012299-86594110 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.
 
Interactions
Mapk10 interacts with 447 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process JNK cascade, JUN phosphorylation, ...
Component cytoplasm, intracellular, ...
Function ATP binding, JUN kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (245)    Tissues (130)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 245
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapk10 ; ZFIN mapk10    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(19) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016343 (Evidence)
Ensembl Gene Model ENSMUSG00000046709 (Evidence)
Entrez Gene 26414 (Evidence)
DFCI TC1576592, TC1590141, TC1597854, TC1590474, TC1599958, TC1599083
DoTS DT.101735368, DT.101391873, DT.101197129, DT.110648893, DT.97362725, DT.94150758, DT.529797
NIA Mouse Gene Index U081043
EC 2.7.11.24
Consensus CDS Project CCDS39185.1, CCDS51574.1
International Mouse Phenotyping Consortium Status Mapk10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016343 VEGA Gene Model | MGI Sequence Detail 298981 C57BL/6J ±  kb
transcript OTTMUST00000039290 VEGA | MGI Sequence Detail 2357 Not Applicable 
polypeptide OTTMUSP00000017557 VEGA | MGI Sequence Detail 494 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(1754 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010151 mitogen-activated protein kinase 10
References
(Earliest) J:30685 Suzuki J, et al., Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res. 1995 Nov;23(4):345-51
(Latest) J:221868 Salvucci O, et al., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576
All references(88)
Other
accession IDs
MGD-MRK-36125, MGI:107554, MGI:2442453

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory