Mapk10
Gene Detail

Symbol Name ID

Mapk10 mitogen-activated protein kinase 10 MGI:1346863

Synonyms

C230008H04Rik, JNK3, p493F12, Serk2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

49.61 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:102912354-103211334 bp, - strand From VEGA annotation of GRCm38   298981 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk10

Human homologs

Human Homolog		MAPK10, mitogen-activated protein kinase 10
NCBI Gene ID		5602
neXtProt AC		NX_P53779
Human Synonyms		JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b
Human Chr (Location)		4q22.1-q23; chr4:86936276-87374283 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAPK10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	JNK cascade, JUN phosphorylation, ...
Component	cytoplasm, membrane, ...
Function	ATP binding, JUN kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (196)    Tissues (81)    Images (41)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	196

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016343 (Evidence)
Ensembl Gene Model	ENSMUSG00000046709 (Evidence)
Entrez Gene	26414 (Evidence)
DFCI	TC1576592, TC1590141, TC1590474, TC1597854, TC1599083, TC1599958
DoTS	DT.101197129, DT.101391873, DT.101735368, DT.110648893, DT.529797, DT.94150758, DT.97362725
NIA Mouse Gene Index	U081043
EC	2.7.11.24
Consensus CDS Project	CCDS39185.1, CCDS51574.1
International Mouse Knockout Project Status	Mapk10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016343	VEGA Gene Model | MGI Sequence Detail	298981	C57BL/6J
transcript	OTTMUST00000039290	VEGA | MGI Sequence Detail	2357	Not Applicable
polypeptide	OTTMUSP00000017557	VEGA | MGI Sequence Detail	494	Not Applicable

All sequences(84) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(1642 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010151	mitogen-activated protein kinase 10

References

(Earliest) J:30685 Suzuki J, et al., Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res. 1995 Nov;23(4):345-51
(Latest) J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Aug 1;
All references(76)

Other accession IDs

MGD-MRK-36125, MGI:107554, MGI:2442453