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Mapk10 Gene Detail
Summary
  • Symbol
    Mapk10
  • Name
    mitogen-activated protein kinase 10
  • Synonyms
    C230008H04Rik, JNK3, p493F12, Serk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346863
    NCBI Gene: 26414
  • Gene Overview
    MyGene.info: MAPK10
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:102908547-103211430 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 49.61 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1758 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346863
protein coding gene Chr5:102907948-103211430 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029799
protein coding gene Chr5:104525140-104826819 (-)
A/J MGP_AJ_G0029763
protein coding gene Chr5:100600801-100899035 (-)
AKR/J MGP_AKRJ_G0029711
protein coding gene Chr5:103838118-104146215 (-)
BALB/cJ MGP_BALBcJ_G0029775
protein coding gene Chr5:101641496-101935967 (-)
C3H/HeJ MGP_C3HHeJ_G0029498
protein coding gene Chr5:104250865-104552588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030230
protein coding gene Chr5:108795220-109095812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027465
protein coding gene Chr5:95773716-96062706 (-)
CAST/EiJ MGP_CASTEiJ_G0028909
protein coding gene Chr5:102949130-103252986 (-)
CBA/J MGP_CBAJ_G0029468
protein coding gene Chr5:112605483-112929417 (-)
DBA/2J MGP_DBA2J_G0029612
protein coding gene Chr5:100790054-101085231 (-)
FVB/NJ MGP_FVBNJ_G0029571
protein coding gene Chr5:99593043-99895882 (-)
LP/J MGP_LPJ_G0029700
protein coding gene Chr5:105097904-105399507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029600
protein coding gene Chr5:117564358-117877563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030263
protein coding gene Chr5:103380127-103686833 (-)
PWK/PhJ MGP_PWKPhJ_G0028627
protein coding gene Chr5:99250637-99537234 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028462
protein coding gene Chr5:101025725-101316308 (-)
WSB/EiJ MGP_WSBEiJ_G0028987
protein coding gene Chr5:103736350-104042223 (-)



Homology
more
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b
  • Links
    NCBI Gene ID: 5602
    neXtProt AC: NX_P53779
    UniProt: P53779

  • Chr Location
    4q21.3; chr4:86012296-86594117 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26414 NCBI Gene Model | MGI Sequence Detail 302884 C57BL/6J ±  kb
    transcript NM_001310683 RefSeq | MGI Sequence Detail 6626 C57BL/6  
    polypeptide Q61831 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • EC
    • InterPro Domains
      IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
      IPR008351 Mitogen-activated protein (MAP) kinase, JNK
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 22
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36125, MGI:107554, MGI:2442453
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 17
      Gene Ontology 13
      Phenotypes 50
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:253375 Larhammar M, et al., Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult. Elife. 2017 Apr 25;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory