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Mapk9 Gene Detail
Summary
  • Symbol
    Mapk9
  • Name
    mitogen-activated protein kinase 9
  • Synonyms
    JNK2, JNK/SAPK alpha, Prkm9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346862
    NCBI Gene: 26420
Location & Maps
more
  • Sequence Map
    Chr11:49846753-49886421 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39669 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 29.96 cM, cytoband B1.2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAPK9, mitogen-activated protein kinase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAPK9, mitogen-activated protein kinase 9
    Orthology source: HomoloGene
  • Synonyms
    JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-55, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a
  • Links
    NCBI Gene ID: 5601
    neXtProt AC: NX_P45984

  • Chr Location
    5q35; chr5:180233594-180292071 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 8 genetic backgrounds
    61 phenotypes from multigenic genotypes
    4 images
    126 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    8
  • Genomic Mutations
    1 involving Mapk9
  • Incidental Mutations
Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005569 VEGA Gene Model | MGI Sequence Detail 39669 C57BL/6J ±  kb
transcript OTTMUST00000012369 VEGA | MGI Sequence Detail 4675 Not Applicable  
polypeptide OTTMUSP00000005725 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010163 mitogen-activated protein kinase 9
  • EC
  • InterPro Domains
    IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
    IPR008351 Mitogen-activated protein (MAP) kinase, JNK
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 151
    cDNA 150
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1202396, MGI:2144306
References
more
  • Summaries
    All 217
    Developmental Gene Expression 39
    Gene Ontology 13
    Phenotypes 126
  • Earliest
    J:37627 Casanova E, et al., Identification of four splice variants of the mouse stress-activated protein kinase JNK/SAPK alpha-isoform. Neuroreport. 1996 May 17;7(7):1320-4
  • Latest
    J:232432 Yun B, et al., Prostaglandins from Cytosolic Phospholipase A2alpha/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages. J Biol Chem. 2016 Mar 25;291(13):7070-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory