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Mapk9
Gene Detail
Symbol

Name
ID
Mapk9
mitogen-activated protein kinase 9
MGI:1346862
Synonyms
JNK2, JNK/SAPK alpha, Prkm9
Feature Type
protein coding gene
Genetic Map
Chromosome 11
29.96 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:49846753-49886421 bp, + strand
From VEGA annotation of GRCm38

  39669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk9

Human
homologs
Human Homolog MAPK9, mitogen-activated protein kinase 9
NCBI Gene ID 5601
neXtProt AC  NX_P45984
Human Synonyms  JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-55, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a
Human Chr (Location)  5q35; chr5:180233594-180292071 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP.
 
Phenotype Images(4)
Interactions
Mapk9 interacts with 379 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (34 records)
Data Summary: Results (81)    Tissues (48)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 48
Western blot 31
cDNA source data(148)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005569 (Evidence)
Ensembl Gene ModelENSMUSG00000020366 (Evidence)
Entrez Gene26420 (Evidence)
UniGene68933
DFCITC1602296, TC1596768, TC1587317, TC1576918, TC1712050
DoTSDT.91570822, DT.110516248, DT.101164780, DT.94151506
NIA Mouse Gene IndexU012540
EC2.7.11.24
Consensus CDS ProjectCCDS24623.1, CCDS24624.1, CCDS48782.1, CCDS48783.1
International Mouse Knockout Project StatusMapk9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005569 VEGA Gene Model | MGI Sequence Detail 39669 C57BL/6J ±  kb
transcript OTTMUST00000012369 VEGA | MGI Sequence Detail 4675 Not Applicable 
polypeptide OTTMUSP00000005725 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010163 mitogen-activated protein kinase 9
References
(Earliest) J:37627 Casanova E, et al., Identification of four splice variants of the mouse stress-activated protein kinase JNK/SAPK alpha-isoform. Neuroreport. 1996 May 17;7(7):1320-4
(Latest) J:214369 Fernandes KA, et al., DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury. Neurobiol Dis. 2014 Sep;69:108-16
All references(207)
Other
accession IDs
MGI:1202396, MGI:2144306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory