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Gene Detail
mitogen-activated protein kinase 9
Synonyms JNK2, JNK/SAPK alpha, Prkm9
Feature Type protein coding gene
Genetic Map
Chromosome 11
29.96 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr11:49846753-49886421 bp, + strand
From VEGA annotation of GRCm38

  39669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk9

Human Homolog MAPK9, mitogen-activated protein kinase 9
NCBI Gene ID 5601
neXtProt AC  NX_P45984
Human Synonyms  JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-55, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a
Human Chr (Location)  5q35; chr5:180233594-180292071 (-)  GRCh38
alleles, and
All mutations/alleles(13) : Gene trapped(6) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP.
Phenotype Images(4)
Mapk9 interacts with 379 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
All GO classifications: (54 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, cellular response to UV, ...
Component cytoplasm, cytosol, ...
Function ATP binding, cysteine-type endopeptidase activator activity involved in apoptotic process, ...
External Resources: FuncBase
Literature Summary: (33 records)
Data Summary: Results (81)    Tissues (48)    Images (13)
Theiler Stages: 20, 21, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 48
Western blot 31
cDNA source data(148)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000005569 (Evidence)
Ensembl Gene ModelENSMUSG00000020366 (Evidence)
Entrez Gene26420 (Evidence)
DFCITC1576918, TC1587317, TC1596768, TC1602296, TC1712050
DoTSDT.101164780, DT.110516248, DT.91570822, DT.94151506
NIA Mouse Gene IndexU012540
Consensus CDS ProjectCCDS24623.1, CCDS24624.1, CCDS48782.1, CCDS48783.1
International Mouse Knockout Project StatusMapk9
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005569 VEGA Gene Model | MGI Sequence Detail 39669 C57BL/6J ±  kb
transcript OTTMUST00000012369 VEGA | MGI Sequence Detail 4675 Not Applicable 
polypeptide OTTMUSP00000005725 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(126 from dbSNP Build 137)
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010163 mitogen-activated protein kinase 9
References (Earliest) J:37627 Casanova E, et al., Identification of four splice variants of the mouse stress-activated protein kinase JNK/SAPK alpha-isoform. Neuroreport. 1996 May 17;7(7):1320-4
(Latest) J:209529 Niedzielska M, et al., Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. J Biol Chem. 2014 Jan 24;289(4):2112-26
All references(204)
accession IDs
MGI:1202396, MGI:2144306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory