Mapk9
Gene Detail

Symbol Name ID

Mapk9 mitogen-activated protein kinase 9 MGI:1346862

Synonyms

JNK2, JNK/SAPK alpha, Prkm9

Feature Type

protein coding gene

Genetic Map

Chromosome 11

29.96 cM, cytoband B1.2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:49846753-49886421 bp, + strand From VEGA annotation of GRCm38   39669 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk9

Human homologs

Human Homolog		MAPK9, mitogen-activated protein kinase 9
NCBI Gene ID		5601
neXtProt AC		NX_P45984
Human Synonyms		JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, JNK-55, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a
Human Chr (Location)		5q35; chr5:179660594-179719071 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(13) : Targeted(7) Gene trapped(6)
 

Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (61 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, cellular response to UV, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, cysteine-type endopeptidase activator activity involved in apoptotic process, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (81)    Tissues (48)    Images (13)
Theiler Stages: 20, 21, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	48
Western blot	31

cDNA source data(150)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(153) cDNA(152) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005569 (Evidence)
Ensembl Gene Model	ENSMUSG00000020366 (Evidence)
Entrez Gene	26420 (Evidence)
UniGene	68933
DFCI	TC1576918, TC1587317, TC1596768, TC1602296, TC1712050
DoTS	DT.101164780, DT.110516248, DT.91570822, DT.94151506
NIA Mouse Gene Index	U012540
EC	2.7.11.24
Consensus CDS Project	CCDS24623.1, CCDS24624.1, CCDS48782.1, CCDS48783.1
International Mouse Knockout Project Status	Mapk9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005569	VEGA Gene Model | MGI Sequence Detail	39669	C57BL/6J
transcript	OTTMUST00000012369	VEGA | MGI Sequence Detail	4675	Not Applicable
polypeptide	OTTMUSP00000005725	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(69) RefSeq(8) UniProt(4)

Polymorphisms

SNPs(119 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010163	mitogen-activated protein kinase 9

References

(Earliest) J:37627 Casanova E, et al., Identification of four splice variants of the mouse stress-activated protein kinase JNK/SAPK alpha-isoform. Neuroreport. 1996 May 17;7(7):1320-4
(Latest) J:193827 Du H, et al., JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82
All references(196)

Other accession IDs

MGI:1202396, MGI:2144306