Esrra
Gene Detail

Symbol Name ID

Esrra estrogen related receptor, alpha MGI:1346831

Synonyms

Err1, ERRalpha, Estrra, Nr3b1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:6910977-6921813 bp, - strand From VEGA annotation of GRCm38   10837 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esrra

Human homologs

Human Homolog		ESRRA, estrogen-related receptor alpha
NCBI Gene ID		2101
neXtProt AC		NX_P11474
Human Synonyms		ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Human Chr (Location)		11q13; chr11:64073044-64084210 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous mice for one mutation were viable but showed reduced weight gain associated with decreased peripheral fat deposition. Mutant mice were resistant to high-fat diet induced obesity. Another targeted mutation resulted in no significant abnormalities in homozygotes.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cartilage development, positive regulation of transcription, DNA-dependent, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (401)    Tissues (293)    Images (113)
Theiler Stages: 13, 17, 18, 19, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	260
In situ reporter (knock in)	92
Northern blot	11
RT-PCR	38

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(57) cDNA(55) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023201 (Evidence)
Ensembl Gene Model	ENSMUSG00000024955 (Evidence)
Entrez Gene	26379 (Evidence)
UniGene	386776
DFCI	TC1579533, TC1618307
NIA Mouse Gene Index	U038662
Consensus CDS Project	CCDS29509.1
International Mouse Knockout Project Status	Esrra

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023201	VEGA Gene Model | MGI Sequence Detail	10837	C57BL/6J
transcript	OTTMUST00000056137	VEGA | MGI Sequence Detail	2242	Not Applicable
polypeptide	OTTMUSP00000026942	VEGA | MGI Sequence Detail	422	Not Applicable

All sequences(42) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR024178	Oestrogen receptor-related nuclear receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000007208	steroid hormone receptor ERR1

References

(Earliest) J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
(Latest) J:180233 Michalek RD, et al., Estrogen-related receptor-alpha is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18348-53
All references(74)

Other accession IDs

MGD-MRK-35850, MGI:107383