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Esrra Gene Detail
Summary
  • Symbol
    Esrra
  • Name
    estrogen related receptor, alpha
  • Synonyms
    Err1, ERRalpha, Estrra, Nr3b1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346831
    NCBI Gene: 26379
Location & Maps
more
  • Sequence Map
    Chr19:6910977-6921813 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10837 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ESRRA, estrogen related receptor alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ESRRA, estrogen related receptor alpha
    Orthology source: HGNC
  • Synonyms
    ERR1, ERRa, ERRalpha, ESRL1, NR3B1
  • Links
    NCBI Gene ID: 2101
    neXtProt AC: NX_P11474

  • Chr Location
    11q13; chr11:64305528-64316743 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 5 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    2
  • Targeted
    7
  • Incidental Mutations
    APF
Homozygous mice for one mutation were viable but showed reduced weight gain associated with decreased peripheral fat deposition. Mutant mice were resistant to high-fat diet induced obesity. Another targeted mutation resulted in no significant abnormalities in homozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023201 VEGA Gene Model | MGI Sequence Detail 10837 C57BL/6J ±  kb
transcript OTTMUST00000056137 VEGA | MGI Sequence Detail 2242 Not Applicable  
polypeptide OTTMUSP00000026942 VEGA | MGI Sequence Detail 422 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    107 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007208 steroid hormone receptor ERR1
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR024178 Oestrogen receptor/oestrogen-related receptor
    IPR027289 Oestrogen-related receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 57
    cDNA 55
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35850, MGI:107383
References
more
  • Summaries
    All 86
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
  • Latest
    J:224429 Wang T, et al., Estrogen-related receptor alpha (ERRalpha) and ERRgamma are essential coordinators of cardiac metabolism and function. Mol Cell Biol. 2015 Apr;35(7):1281-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory