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Esrra
Gene Detail
Symbol

Name
ID
Esrra
estrogen related receptor, alpha
MGI:1346831
Synonyms
Err1, ERRalpha, Estrra, Nr3b1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:6910977-6921813 bp, - strand
From VEGA annotation of GRCm38

  10837 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20941  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ER-like_NR
Gene Tree: Esrra

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous mice for one mutation were viable but showed reduced weight gain associated with decreased peripheral fat deposition. Mutant mice were resistant to high-fat diet induced obesity. Another targeted mutation resulted in no significant abnormalities in homozygotes.
 
Interactions
Esrra interacts with 232 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cartilage development, negative regulation of transcription from RNA polymerase II promoter, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (401)    Tissues (294)    Images (113)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 260
In situ reporter (knock in) 92
Northern blot 11
RT-PCR 38
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(55) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023201 (Evidence)
Ensembl Gene ModelENSMUSG00000024955 (Evidence)
Entrez Gene26379 (Evidence)
UniGene386776
DFCITC1579533, TC1618307
NIA Mouse Gene IndexU038662
Consensus CDS ProjectCCDS29509.1
International Mouse Knockout Project StatusEsrra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023201 VEGA Gene Model | MGI Sequence Detail 10837 C57BL/6J ±  kb
transcript OTTMUST00000056137 VEGA | MGI Sequence Detail 2242 Not Applicable 
polypeptide OTTMUSP00000026942 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(10) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR024178 Oestrogen receptor/oestrogen-related receptor
InterPro IPR027289 Oestrogen-related receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000007208 steroid hormone receptor ERR1
References
(Earliest) J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
(Latest) J:210709 LaBarge S, et al., Estrogen-related receptor-alpha (ERRalpha) deficiency in skeletal muscle impairs regeneration in response to injury. FASEB J. 2014 Mar;28(3):1082-97
All references(81)
Other
accession IDs
MGD-MRK-35850, MGI:107383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory