Esrra Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Esrra
estrogen related receptor, alpha
MGI:1346831

38 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Esrra^{tm1.1(KOMP)Vlcg}/Esrra^{tm1.1(KOMP)Vlcg} C57BL/6N-Esrra^{tm1.1(KOMP)Vlcg}/J	decreased vertical activity	J:211773
	hyperactivity	J:211773
	increased circulating alanine transaminase level	J:211773
	increased grip strength	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased startle reflex	J:211773
	shortened PQ interval	J:211773
Esrra^tm1.1Ics/Esrra^tm1.1Ics Tg(Col1a1-cre)1Kry/0 involves: 129S2/SvPas * FVB	abnormal skeleton physiology	J:195925
	abnormal trabecular bone morphology	J:195925
Esrra^tm1Dgen/Esrra^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Esrra^tm1Vgi/Esrra^tm1Vgi involves: 129S1/Sv * 129X1/SvJ	abnormal bone structure	J:160910
	abnormal osteoclast differentiation	J:160910
	abnormal trabecular bone morphology	J:160910
	decreased bone marrow cell number	J:160910
	decreased bone resorption	J:160910
	decreased osteoclast cell number	J:160910
	extramedullary hematopoiesis	J:160910
	increased osteoblast cell number	J:160910
	increased splenocyte number	J:160910
	increased trabecular bone volume	J:160910
	osteopetrosis	J:160910
Esrra^tm1Vgi/Esrra^tm1Vgi involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal adipose tissue physiology	J:86433
	abnormal cellular respiration	J:119525
	abnormal lipid homeostasis	J:86433
	decreased body weight	J:86433
	decreased epididymal fat pad weight	J:86433
	decreased fat cell mitochondrial DNA content	J:119525
	decreased inguinal fat pad weight	J:86433
	decreased mitochondrial number	J:119525
	decreased percent body fat/body weight	J:86433
	decreased retroperitoneal fat pad weight	J:86433
	decreased white fat cell size	J:86433
	normal homeostasis/metabolism phenotype	J:86433
	impaired adaptive thermogenesis	J:119525
	increased brown fat cell lipid droplet size	J:119525
	increased lean body mass	J:86433
	increased percent water in carcass	J:86433
	increased triglyceride level	J:119525
Esrra^tm1Vgi/Esrra^tm1Vgi involves: C57BL/6	decreased susceptibility to diet-induced obesity	J:86433

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23