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Bace1
Gene Detail
Symbol

Name
ID
Bace1
beta-site APP cleaving enzyme 1
MGI:1346542
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:45838580-45864399 bp, + strand
From VEGA annotation of GRCm38

  25820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8014  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: memapsin
Gene Tree: Bace1

Human
homologs
Human Homolog BACE1, beta-site APP-cleaving enzyme 1
NCBI Gene ID 23621
neXtProt AC  NX_P56817
Human Synonyms  ASP2, BACE, HSPC104
Human Chr (Location)  11q23.2-q23.3; chr11:117285686-117316256 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(1) Targeted(14)
Incidental mutations (data from APF )
 
Some alleles with a targeted mutation exhibit small body size, postnatal lethality, hyperactivity, decreased anxiety, and abnormal APP processing by neurons, while others appear normal.
 
Interactions
Bace1 interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process beta-amyloid metabolic process, membrane protein ectodomain proteolysis, ...
Component axon, cytoplasmic vesicle, ...
Function aspartic-type endopeptidase activity, beta-amyloid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (15)    Tissues (4)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 2
Western blot 4
RT-PCR 9
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000034962 (Evidence)
Ensembl Gene ModelENSMUSG00000032086 (Evidence)
Entrez Gene23821 (Evidence)
DFCITC1574086, TC1599476, TC1605879, TC1722353
EC3.4.23.46
Consensus CDS ProjectCCDS23135.1, CCDS52784.1
International Mouse Knockout Project StatusBace1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034962 VEGA Gene Model | MGI Sequence Detail 25820 C57BL/6J ±  kb
transcript OTTMUST00000088890 VEGA | MGI Sequence Detail 6058 Not Applicable 
polypeptide OTTMUSP00000048510 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(8)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021109 Aspartic peptidase
InterPro IPR001461 Peptidase A1
InterPro IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
InterPro IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
InterPro IPR001969 Peptidase aspartic, active site
Protein Ontology PR:000004615 beta-secretase 1
References
(Earliest) J:43334 Vassar R, et al., Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [see comments]. Science. 1999 Oct 22;286(5440):735-41
(Latest) J:211050 Kallop DY, et al., A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models. J Neurosci. 2014 May 7;34(19):6425-37
All references(104)
Other
accession IDs
MGI:2143381

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory