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Psmb9 Gene Detail
Summary
  • Symbol
    Psmb9
  • Name
    proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
  • Synonyms
    Lmp2, Lmp-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346526
    NCBI Gene: 16912
  • Gene Overview
    MyGene.info: PSMB9
Location & Maps
more
  • Sequence Map
    Chr17:34181988-34187764 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5777 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    PSMB9, proteasome subunit beta 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PSMB9, proteasome subunit beta 9
    Orthology source: HomoloGene
  • Synonyms
    beta1i, LMP2, PSMB6i, RING12
  • Links
    NCBI Gene ID: 5698
    neXtProt AC: NX_P28065

  • Chr Location
    6p21.3; chr6:32854161-32859851 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a grossly normal phenotype but suffer from increased susceptibility to some viruses and have an increased risk of tumor development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036472 VEGA Gene Model | MGI Sequence Detail 5777 C57BL/6J ±  kb
transcript OTTMUST00000093460 VEGA | MGI Sequence Detail 1351 Not Applicable  
polypeptide OTTMUSP00000051839 VEGA | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 51
    Genomic 23
    cDNA 22
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11821, MGD-MRK-11823, MGI:96797
References
more
  • Summaries
    All 85
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
  • Latest
    J:206749 Cui Z, et al., Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan;34(1):96-109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory