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Clca3
Gene Detail
 Symbol
Name
ID
Clca3
chloride channel calcium activated 3
MGI:1346342
Synonyms gob5, gob-5
Feature Type protein coding gene
Genetic Map
Chromosome 3
69.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:145004537-145032776 bp, - strand
From NCBI annotation of GRCm38

  28240 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca3

Human
homologs
Human Homolog CLCA1, chloride channel accessory 1
NCBI Gene ID 1179
neXtProt AC  NX_A8K7I4
Human Synonyms  CACC, CaCC-1, CACC1, CLCRG1, GOB5, hCaCC-1, hCLCA1
Human Chr (Location)  1p22.3; chr1:86468843-86500294 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit an exacerbated mucin response.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process calcium ion transport, chloride transmembrane transport, ...
Component extracellular region, integral component of membrane, ...
Function chloride channel activity
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (22)    Tissues (17)    Images (6)
Theiler Stages: 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 11
RT-PCR 11
cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(74) cDNA(72) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028255 (Evidence)
Entrez Gene23844 (Evidence)
UniGene33483
DFCITC1577725, TC1735072
DoTSDT.534600
NIA Mouse Gene IndexU024734
Consensus CDS ProjectCCDS17889.1
International Mouse Knockout Project StatusClca3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23844 NCBI Gene Model | MGI Sequence Detail 28240 C57BL/6J ±  kb
transcript NM_017474 RefSeq | MGI Sequence Detail 2935 C57BL/6 
polypeptide Q9D7Z6 UniProt | EBI | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004727 Calcium-activated chloride channel protein
InterPro IPR013642 Chloride channel calcium-activated
InterPro IPR015394 Domain of unknown function DUF1973
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000005523 calcium-activated chloride channel regulator 1
Graphical View of Protein Domain Structure
References (Earliest) J:53044 Komiya T, et al., Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun. 1999 Feb 16;255(2):347-51
(Latest) J:195044 Wang Y, et al., Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory