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Clca1
Gene Detail
Symbol

Name
ID
Clca1
chloride channel calcium activated 1
MGI:1346342
Synonyms
Clca3, gob5, gob-5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
69.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:145004537-145032776 bp, - strand
From NCBI annotation of GRCm38

  28240 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CLCA1
Protein SuperFamily: calcium-activated chloride channel
Gene Tree: Clca1

Human
homologs
CLCA1, chloride channel accessory 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1179
neXtProt AC: NX_A8K7I4

Human Synonyms: CACC, CaCC-1, CACC1, CLCRG1, GOB5, hCaCC-1, hCLCA1

Human Chr (Location): 1p22.3; chr1:86468843-86500294 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit an exacerbated mucin response.
 
Interactions
Clca1 interacts with 51 markers (Mir103-1, Mir103-2, Mir107, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (22)    Tissues (18)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
RT-PCR 11
cDNA source data(72)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(74) cDNA(72) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000028255 (Evidence)
Entrez Gene 23844 (Evidence)
UniGene 33483
DFCI TC1577725, TC1735072
DoTS DT.534600
NIA Mouse Gene Index U024734
EC 3.4.-.-
Consensus CDS Project CCDS17889.1
International Mouse Phenotyping Consortium Status Clca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23844 NCBI Gene Model | MGI Sequence Detail 28240 C57BL/6J ±  kb
transcript NM_017474 RefSeq | MGI Sequence Detail 2935 C57BL/6 
polypeptide Q9D7Z6 UniProt | EBI | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004727 Calcium-activated chloride channel protein
InterPro IPR013642 Chloride channel calcium-activated
InterPro IPR015394 Domain of unknown function DUF1973
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000005523 calcium-activated chloride channel regulator 1
Graphical View of Protein Domain Structure
References
(Earliest) J:53044 Komiya T, et al., Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun. 1999 Feb 16;255(2):347-51
(Latest) J:219027 Dietert K, et al., mCLCA3 modulates IL-17 and CXCL-1 induction and leukocyte recruitment in murine Staphylococcus aureus pneumonia. PLoS One. 2014;9(7):e102606
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory