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Apc2 Gene Detail
Summary
  • Symbol
    Apc2
  • Name
    adenomatosis polyposis coli 2
  • Synonyms
    APCL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346052
    NCBI Gene: 23805
Location & Maps
more
  • Sequence Map
    Chr10:80295977-80318263 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22287 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband B5-C2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    APC2, adenomatosis polyposis coli 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APC2, adenomatosis polyposis coli 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APCL
  • Links
    NCBI Gene ID: 10297
    neXtProt AC: NX_O95996

  • Chr Location
    19p13.3; chr19:1446268-1473244 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4299
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: APC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Apc2
  • Incidental Mutations
Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000013 VEGA Gene Model | MGI Sequence Detail 22287 C57BL/6J ±  kb
transcript OTTMUST00000045729 VEGA | MGI Sequence Detail 9173 Not Applicable  
polypeptide OTTMUSP00000020592 VEGA | MGI Sequence Detail 2303 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004123 adenomatous polyposis coli protein 2
  • InterPro Domains
    IPR026837 Adenomatous polyposis coli 2
    IPR026818 Adenomatous polyposis coli (APC) family
    IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
    IPR026831 Adenomatous polyposis coli protein
    IPR009234 Adenomatous polyposis coli protein basic domain
    IPR009223 Adenomatous polyposis coli protein repeat
    IPR000225 Armadillo
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
Molecular
Reagents
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  • All nucleic 9
    Genomic 2
    cDNA 6
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2143692, MGI:2143960
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:57577 Bell SM, et al., Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. Cytogenet Cell Genet. 1999;86(1):81-2
  • Latest
    J:227851 Pataskar A, et al., NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program. EMBO J. 2016 Jan 4;35(1):24-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory