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Apc2 Gene Detail
Summary
  • Symbol
    Apc2
  • Name
    adenomatosis polyposis coli 2
  • Synonyms
    APCL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346052
    NCBI Gene: 23805
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80295977-80318263 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband B5-C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346052
protein coding gene Chr10:80295958-80318263 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017494
protein coding gene Chr10:80895600-80917855 (+)
A/J MGP_AJ_G0017472
protein coding gene Chr10:78061415-78084624 (+)
AKR/J MGP_AKRJ_G0017433
protein coding gene Chr10:80198397-80220615 (+)
BALB/cJ MGP_BALBcJ_G0017434
protein coding gene Chr10:78291956-78314223 (+)
C3H/HeJ MGP_C3HHeJ_G0017257
protein coding gene Chr10:80290717-80312979 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017888
protein coding gene Chr10:83698085-83721812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015576
protein coding gene Chr10:74283217-74305518 (+)
CAST/EiJ MGP_CASTEiJ_G0016824
protein coding gene Chr10:80499275-80523057 (+)
CBA/J MGP_CBAJ_G0017229
protein coding gene Chr10:86927344-86951266 (+)
DBA/2J MGP_DBA2J_G0017335
protein coding gene Chr10:77280729-77302991 (+)
FVB/NJ MGP_FVBNJ_G0017329
protein coding gene Chr10:76469683-76492299 (+)
LP/J MGP_LPJ_G0017406
protein coding gene Chr10:81367386-81389441 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017355
protein coding gene Chr10:88870515-88892743 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017929
protein coding gene Chr10:80186082-80208388 (+)
PWK/PhJ MGP_PWKPhJ_G0016605
protein coding gene Chr10:77149652-77172687 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016394
protein coding gene Chr10:79158991-79182096 (+)
WSB/EiJ MGP_WSBEiJ_G0016884
protein coding gene Chr10:80218934-80241138 (+)



Homology
more
  • Human Ortholog
    APC2, APC2, WNT signaling pathway regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APC2, APC2, WNT signaling pathway regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APCL
  • Links
    NCBI Gene ID: 10297
    neXtProt AC: NX_O95996
    UniProt: O95996

  • Chr Location
    19p13.3; chr19:1446268-1473244 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4299
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020135 Ensembl Gene Model | MGI Sequence Detail 22287 C57BL/6J ±  kb
    transcript ENSMUST00000105359 Ensembl | MGI Sequence Detail 9173 Not Applicable  
    polypeptide ENSMUSP00000100996 Ensembl | MGI Sequence Detail 2303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR026837 Adenomatous polyposis coli 2
      IPR026818 Adenomatous polyposis coli (APC) family
      IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
      IPR026831 Adenomatous polyposis coli protein
      IPR009234 Adenomatous polyposis coli protein basic domain
      IPR009223 Adenomatous polyposis coli protein repeat
      IPR036149 APC, N-terminal coiled-coil domain superfamily
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 2
      cDNA 7
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143692, MGI:2143960
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260948 Young MA, et al., Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells. Stem Cells. 2018 Jan;36(1):114-122

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory