Apc2 MGI Mouse Gene Detail - MGI:1346052 - APC regulator of WNT signaling pathway 2

Symbol

Apc2
Name

APC regulator of WNT signaling pathway 2
Synonyms

APCL

Feature Type

protein coding gene
IDs

MGI:1346052
NCBI Gene: 23805
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:80131811-80154097 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband B5-C2
Mapping Data

3 experiments

SNPs within 2kb

441 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346052	protein coding gene	Chr10:80131790-80154097 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017494	protein coding gene	Chr10:80895600-80917855 (+)
A/J	MGP_AJ_G0017472	protein coding gene	Chr10:78061415-78084624 (+)
AKR/J	MGP_AKRJ_G0017433	protein coding gene	Chr10:80198397-80220615 (+)
BALB/cJ	MGP_BALBcJ_G0017434	protein coding gene	Chr10:78291956-78314223 (+)
C3H/HeJ	MGP_C3HHeJ_G0017257	protein coding gene	Chr10:80290717-80312979 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017888	protein coding gene	Chr10:83698085-83721812 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015576	protein coding gene	Chr10:74283217-74305518 (+)
CAST/EiJ	MGP_CASTEiJ_G0016824	protein coding gene	Chr10:80499275-80523057 (+)
CBA/J	MGP_CBAJ_G0017229	protein coding gene	Chr10:86927344-86951266 (+)
DBA/2J	MGP_DBA2J_G0017335	protein coding gene	Chr10:77280729-77302991 (+)
FVB/NJ	MGP_FVBNJ_G0017329	protein coding gene	Chr10:76469683-76492299 (+)
LP/J	MGP_LPJ_G0017406	protein coding gene	Chr10:81367386-81389441 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017355	protein coding gene	Chr10:88870515-88892743 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017929	protein coding gene	Chr10:80186082-80208388 (+)
PWK/PhJ	MGP_PWKPhJ_G0016605	protein coding gene	Chr10:77149652-77172687 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016394	protein coding gene	Chr10:79158991-79182096 (+)
WSB/EiJ	MGP_WSBEiJ_G0016884	protein coding gene	Chr10:80218934-80241138 (+)

Human Ortholog

APC2, APC regulator of WNT signaling pathway 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APC2, APC regulator of WNT signaling pathway 2
Synonyms

APCL, MRT74
Links

HGNC:24036

NCBI Gene ID: 10297

UniProt: O95996
Chr Location

19p13.3; chr19:1446230-1473244 (+) GRCh38

MGI Vertebrate Homology

Apc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APC2
Gene Tree

Apc2

Diseases

4 with human APC2 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 74 IDs autosomal recessive intellectual developmental disorder 74 DOID:0081218 OMIM:617169
				complex cortical dysplasia with other brain malformations IDs complex cortical dysplasia with other brain malformations DOID:0090131 OMIM:PS614039
				nicotine dependence IDs nicotine dependence DOID:0050742 EFO:0003768 ICD10CM:F17 MESH:D014029 NCI:C54203 UMLS_CUI:C0028043
				Sotos syndrome 3 IDs Sotos syndrome 3 DOID:0112104 OMIM:617169

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Apc2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.

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All GO Annotations

53
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

967
Tissues

131
cDNA Data

8
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase apc2

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All Sequences

74
RefSeq

14
UniProt

7
CCDS

CCDS24016.1, CCDS88053.1

Ensembl

ENSMUSG00000020135 (Evidence)
NCBI Gene

23805

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020135	Ensembl Gene Model \| MGI Sequence Detail	22287	C57BL/6J	± kb
transcript	ENSMUST00000105359	Ensembl \| MGI Sequence Detail	9173	Not Applicable
polypeptide	ENSMUSP00000100996	Ensembl \| MGI Sequence Detail	2303	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004123 adenomatous polyposis coli protein 2

(term hierarchy)
InterPro Domains

IPR026818 Adenomatous polyposis coli (APC) family

IPR041257 Adenomatous polyposis coli (APC) repeat

IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain

IPR026831 Adenomatous polyposis coli protein

IPR009234 Adenomatous polyposis coli protein basic domain

IPR009223 Adenomatous polyposis coli protein repeat

IPR036149 APC, N-terminal coiled-coil domain superfamily

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR009224 SAMP
GlyGen

Q9Z1K7 8 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 12

Genomic 2

cDNA 8

Primer pair 2

Microarray probesets 4

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MGI:2143692, MGI:2143960

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687

TSS for Apc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94543	Chr10:80131764-80131837 (+)	-10 bp
Tssr94544	Chr10:80134918-80134960 (+)	3,128 bp
Tssr94545	Chr10:80134966-80134996 (+)	3,170 bp
Tssr94546	Chr10:80135004-80135007 (+)	3,195 bp
Tssr94547	Chr10:80136831-80136884 (+)	5,047 bp
Tssr94548	Chr10:80144113-80144117 (+)	12,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24