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Apc2
Gene Detail
Symbol

Name
ID
Apc2
adenomatosis polyposis coli 2
MGI:1346052
Synonyms
APCL
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband B5-C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:80295977-80318263 bp, + strand
From VEGA annotation of GRCm38

  22287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: APC2
Gene Tree: Apc2

Human
homologs
APC2, adenomatosis polyposis coli 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10297
neXtProt AC: NX_O95996

Human Synonyms: APCL

Human Chr (Location): 19p13.3; chr19:1446268-1473244 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.
 
Interactions
Apc2 interacts with 237 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (252)    Tissues (127)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
Northern blot 9
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apc2    NEW 
Molecular
reagents
All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000013 (Evidence)
Ensembl Gene Model ENSMUSG00000020135 (Evidence)
Entrez Gene 23805 (Evidence)
NIA Mouse Gene Index U011748
Consensus CDS Project CCDS24016.1
International Mouse Phenotyping Consortium Status Apc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000013 VEGA Gene Model | MGI Sequence Detail 22287 C57BL/6J ±  kb
transcript OTTMUST00000045729 VEGA | MGI Sequence Detail 9173 Not Applicable 
polypeptide OTTMUSP00000020592 VEGA | MGI Sequence Detail 2303 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(6)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026837 Adenomatous polyposis coli 2
InterPro IPR026818 Adenomatous polyposis coli (APC) family
InterPro IPR026831 Adenomatous polyposis coli domain
InterPro IPR009234 Adenomatous polyposis coli protein basic domain
InterPro IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR009224 SAMP
Protein Ontology PR:000004123 adenomatous polyposis coli protein 2
References
(Earliest) J:57577 Bell SM, et al., Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. Cytogenet Cell Genet. 1999;86(1):81-2
(Latest) J:184856 Shintani T, et al., Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2. J Neurosci. 2012 May 9;32(19):6468-84
All references(27)
Other
accession IDs
MGI:2143692, MGI:2143960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory