Apc2
Gene Detail

Symbol

Name
ID

Apc2
adenomatosis polyposis coli 2
MGI:1346052

Synonyms

APCL

Feature Type

protein coding gene

Genetic Map

Chromosome 10
39.72 cM, cytoband B5-C2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:80295977-80318263 bp, + strand From VEGA annotation of GRCm38   22287 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Apc2

Human
homologs

Human Homolog		APC2, adenomatosis polyposis coli 2
NCBI Gene ID		10297
neXtProt AC		NX_O95996
Human Synonyms		APCL
Human Chr (Location)		19p13.3; chr19:1446270-1473244 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.

 

Interactions

Apc2 interacts with 238 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (11 annotations)

Process	negative regulation of canonical Wnt signaling pathway, negative regulation of catenin import into nucleus
Component	actin filament, catenin complex, ...
Function	beta-catenin binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (252)    Tissues (127)    Images (50)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	243
Northern blot	9

cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000000013 (Evidence)
Ensembl Gene Model	ENSMUSG00000020135 (Evidence)
Entrez Gene	23805 (Evidence)
NIA Mouse Gene Index	U011748
Consensus CDS Project	CCDS24016.1
International Mouse Knockout Project Status	Apc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000013	VEGA Gene Model | MGI Sequence Detail	22287	C57BL/6J
transcript	OTTMUST00000045729	VEGA | MGI Sequence Detail	9173	Not Applicable
polypeptide	OTTMUSP00000020592	VEGA | MGI Sequence Detail	2303	Not Applicable

All sequences(61) RefSeq(10) UniProt(6)

Polymorphisms

SNPs within 2kb(66 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR026837	Adenomatous polyposis coli 2
InterPro	IPR026818	Adenomatous polyposis coli (APC) family
InterPro	IPR026831	Adenomatous polyposis coli domain
InterPro	IPR009234	Adenomatous polyposis coli protein basic domain
InterPro	IPR009223	Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro	IPR000225	Armadillo
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR009224	SAMP
Protein Ontology	PR:000004123	adenomatous polyposis coli protein 2

References

(Earliest) J:57577 Bell SM, et al., Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. Cytogenet Cell Genet. 1999;86(1):81-2
(Latest) J:184856 Shintani T, et al., Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2. J Neurosci. 2012 May 9;32(19):6468-84
All references(28)

Other
accession IDs

MGI:2143692, MGI:2143960