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Gene Detail
adenomatosis polyposis coli 2
Synonyms APCL
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband B5-C2
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr10:80295977-80318263 bp, + strand
From VEGA annotation of GRCm38

  22287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:4299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Apc2

Human Homolog APC2, adenomatosis polyposis coli 2
NCBI Gene ID 10297
neXtProt AC  NX_O95996
Human Synonyms  APCL
Human Chr (Location)  19p13.3; chr19:1446270-1473244 (+)  GRCh38
alleles, and
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination.
Apc2 interacts with 238 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
All GO classifications: (11 annotations)
Process negative regulation of canonical Wnt signaling pathway, negative regulation of catenin import into nucleus
Component actin filament, catenin complex, ...
Function beta-catenin binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (252)    Tissues (127)    Images (50)
Theiler Stages: 16, 18, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 243
Northern blot 9
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(9) Genomic(2) cDNA(6) Primer pair(1)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000000013 (Evidence)
Ensembl Gene ModelENSMUSG00000020135 (Evidence)
Entrez Gene23805 (Evidence)
NIA Mouse Gene IndexU011748
Consensus CDS ProjectCCDS24016.1
International Mouse Knockout Project StatusApc2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000013 VEGA Gene Model | MGI Sequence Detail 22287 C57BL/6J ±  kb
transcript OTTMUST00000045729 VEGA | MGI Sequence Detail 9173 Not Applicable 
polypeptide OTTMUSP00000020592 VEGA | MGI Sequence Detail 2303 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
InterPro IPR026837 Adenomatous polyposis coli 2
InterPro IPR026818 Adenomatous polyposis coli (APC) family
InterPro IPR026831 Adenomatous polyposis coli domain
InterPro IPR009234 Adenomatous polyposis coli protein basic domain
InterPro IPR009223 Adenomatous polyposis coli protein, cysteine-rich repeat
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR009224 SAMP
Protein Ontology PR:000004123 adenomatous polyposis coli protein 2
References (Earliest) J:57577 Bell SM, et al., Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. Cytogenet Cell Genet. 1999;86(1):81-2
(Latest) J:184856 Shintani T, et al., Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2. J Neurosci. 2012 May 9;32(19):6468-84
All references(28)
accession IDs
MGI:2143692, MGI:2143960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory