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Hs2st1 Gene Detail
Summary
  • Symbol
    Hs2st1
  • Name
    heparan sulfate 2-O-sulfotransferase 1
  • Synonyms
    Hs2st, mKIAA0448
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346049
    NCBI Gene: 23908
  • Gene Overview
    MyGene.info: HS2ST1
Location & Maps
more
  • Sequence Map
    Chr3:144429706-144570181 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      140476 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 68.89 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HS2ST1, heparan sulfate 2-O-sulfotransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HS2ST1, heparan sulfate 2-O-sulfotransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dJ604K5.2
  • Links
    NCBI Gene ID: 9653
    neXtProt AC: NX_Q7LGA3

  • Chr Location
    1p22.3; chr1:86914652-87109998 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8025
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HS2ST1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Hs2st1
  • Incidental Mutations
A mutation in this gene causes bilateral renal agenesis, bone defects, eye development abnormalities and cataracts in homozygous mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034172 VEGA Gene Model | MGI Sequence Detail 140476 C57BL/6J ±  kb
transcript OTTMUST00000086647 VEGA | MGI Sequence Detail 6177 Not Applicable  
polypeptide OTTMUSP00000046919 VEGA | MGI Sequence Detail 356 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1070 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR007734 Heparan sulphate 2-O-sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005331 Sulfotransferase
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2139978
References
more
  • Summaries
    All 47
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:48481 Bullock SL, et al., Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 1998 Jun 15;12(12):1894-906
  • Latest
    J:229211 Xiong A, et al., Heparan sulfate in the regulation of neural differentiation and glioma development. FEBS J. 2014 Nov;281(22):4993-5008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory