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Pin1 Gene Detail
Summary
  • Symbol
    Pin1
  • Name
    protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
  • Synonyms
    0610025L01Rik, D9Bwg1161e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346036
    NCBI Gene: 23988
  • Gene Overview
    MyGene.info: PIN1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20652130-20666584 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346036
protein coding gene Chr9:20652095-20666584 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034424
protein coding gene Chr9:17796402-17812954 (+)
A/J MGP_AJ_G0034402
protein coding gene Chr9:17515046-17530070 (+)
AKR/J MGP_AKRJ_G0034329
protein coding gene Chr9:17834163-17850512 (+)
BALB/cJ MGP_BALBcJ_G0034393
protein coding gene Chr9:17418990-17433857 (+)
C3H/HeJ MGP_C3HHeJ_G0034105
protein coding gene Chr9:18146282-18160598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034914
protein coding gene Chr9:18516452-18531440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031844
protein coding gene Chr9:16651812-16665658 (+)
CAST/EiJ MGP_CASTEiJ_G0033428
protein coding gene Chr9:17956097-17973799 (+)
CBA/J MGP_CBAJ_G0034078
protein coding gene Chr9:19231933-19246393 (+)
DBA/2J MGP_DBA2J_G0034237
protein coding gene Chr9:17511417-17525863 (+)
FVB/NJ MGP_FVBNJ_G0034180
protein coding gene Chr9:17011126-17026127 (+)
LP/J MGP_LPJ_G0034322
protein coding gene Chr9:17982407-17998070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034223
protein coding gene Chr9:20867859-20885686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034934
protein coding gene Chr9:17779586-17794028 (+)
PWK/PhJ MGP_PWKPhJ_G0033134
protein coding gene Chr9:17472689-17487565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032968
protein coding gene Chr9:17818276-17836447 (+)
WSB/EiJ MGP_WSBEiJ_G0033543
protein coding gene Chr9:17509882-17524572 (+)



Homology
more
  • Human Ortholog
    PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOD, UBL5
  • Links
    NCBI Gene ID: 5300
    neXtProt AC: NX_Q13526
    UniProt: Q13526

  • Chr Location
    19p13.2; chr19:9835207-9849689 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pin1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes exhibit cell-proliferation abnormalities, including a late-developing reduction in body weight and progressive testicular and retinal atrophies. Mutant females fail to undergo mammary epithelial duct expansion associated with pregnancy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23988 NCBI Gene Model | MGI Sequence Detail 14455 C57BL/6J ±  kb
    transcript NM_023371 RefSeq | MGI Sequence Detail 948 C57BL/6  
    polypeptide Q9QUR7 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
    • InterPro Domains
      IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
      IPR023058 Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
      IPR001202 WW domain
      IPR036020 WW domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34105, MGI:106411, MGI:1914920
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 15
      Phenotypes 62
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:257506 Liang ES, et al., Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE(-/-) mice. J Mol Cell Cardiol. 2018 Jan;114:334-344

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory