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Pin1
Gene Detail
 Symbol
Name
ID
Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
MGI:1346036
Synonyms 0610025L01Rik, D9Bwg1161e
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:20652130-20666584 bp, + strand
From NCBI annotation of GRCm38

  14455 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ESS1 protein
Gene Tree: Pin1

Human
homologs
Human Homolog PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
NCBI Gene ID 5300
neXtProt AC  NX_Q13526
Human Synonyms  DOD, UBL5
Human Chr (Location)  19p13; chr19:9835207-9849689 (+)  GRCh38
Alleles
and
phenotypes
All alleles(33) : Gene trapped(30) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes exhibit cell-proliferation abnormalities, including a late-developing reduction in body weight and progressive testicular and retinal atrophies. Mutant females fail to undergo mammary epithelial duct expansion associated with pregnancy.
 
Human Diseases Modeled Using Mouse Pin1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, negative regulation of cell motility, ...
Component cytoplasm, midbody, ...
Function GTPase activating protein binding, isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (11)    Images (8)
Theiler Stages: 2, 3, 11, 13, 15, 21, 23, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 2
RT-PCR 36
cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(112) cDNA(110) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032171 (Evidence)
Entrez Gene23988 (Evidence)
UniGene7906
DFCITC1572539, TC1672256
DoTSDT.111201488, DT.534655
NIA Mouse Gene IndexU010124
EC5.2.1.8
Consensus CDS ProjectCCDS22882.1
International Mouse Knockout Project StatusPin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 23988 NCBI Gene Model | MGI Sequence Detail 14455 C57BL/6J ±  kb
transcript NM_023371 RefSeq | MGI Sequence Detail 3808 C57BL/6 
polypeptide Q9QUR7 UniProt | EBI | MGI Sequence Detail 165 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
InterPro IPR023058 Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
InterPro IPR001202 WW domain
Protein Ontology PR:000012735 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Graphical View of Protein Domain Structure
References (Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:205545 Sorrentino G, et al., The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Differ. 2013 Feb;20(2):198-208
All references(99)
Other
accession IDs
MGD-MRK-34105, MGI:106411, MGI:1914920

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory