Pin1
Gene Detail

Symbol Name ID

Pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 MGI:1346036

Synonyms

0610025L01Rik, D9Bwg1161e

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:20652130-20666584 bp, + strand From NCBI annotation of GRCm38   14455 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ESS1 protein
Gene Tree: Pin1

Human homologs

Human Homolog		PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
NCBI Gene ID		5300
neXtProt AC		NX_Q13526
Human Synonyms		DOD, UBL5
Human Chr (Location)		19p13; chr19:9945883-9960365 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(33) : Targeted(3) Gene trapped(30)
 

Homozygotes exhibit cell-proliferation abnormalities, including a late-developing reduction in body weight and progressive testicular and retinal atrophies. Mutant females fail to undergo mammary epithelial duct expansion associated with pregnancy.

 
Human Diseases Modeled Using Mouse Pin1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell cycle, negative regulation of cell motility, ...
Component	cytoplasm, midbody, ...
Function	GTPase activating protein binding, isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (46)    Tissues (11)    Images (8)
Theiler Stages: 2, 3, 11, 13, 15, 21, 23, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	2
RT-PCR	36

cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(112) cDNA(110) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032171 (Evidence)
Entrez Gene	23988 (Evidence)
UniGene	7906
DFCI	TC1572539, TC1672256
DoTS	DT.111201488, DT.534655
NIA Mouse Gene Index	U010124
EC	5.2.1.8
Consensus CDS Project	CCDS22882.1
International Mouse Knockout Project Status	Pin1

Sequences

Length	Strain/Species
genomic	23988	NCBI Gene Model | MGI Sequence Detail	14455	C57BL/6J
transcript	NM_023371	RefSeq | MGI Sequence Detail	3808	C57BL/6
polypeptide	Q9QUR7	UniProt | EBI | MGI Sequence Detail	165	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000297	Peptidyl-prolyl cis-trans isomerase, PpiC-type
InterPro	IPR023058	Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000012735	peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Graphical View of Protein Domain Structure

References

(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:188366 Shen ZJ, et al., Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem. 2012 Jul 6;287(28):23294-305
All references(86)

Other accession IDs

MGD-MRK-34105, MGI:106411, MGI:1914920