Phenotypes Associated with This Genotype

Genotype
MGI:5433612

• Allelic Composition: Pin1^tm1Tuc/Pin1^tm1Tuc
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:107132 )

• levels of insoluble amyloid beta42 are increased by 32% in the brains of mutants at 15 months of age compared to wild-type mice

• however, no changes in the levels of amyloid beta40 or amyloid beta42 is seen at 2-6 months of age

• these results indicate an age-dependent and selective increase in insoluble amyloid beta42 as observed in Alzheimer's patients

homeostasis/metabolism

amyloid beta deposits ( J:107132 )

• levels of insoluble amyloid beta42 are increased by 32% in the brains of mutants at 15 months of age compared to wild-type mice

• however, no changes in the levels of amyloid beta40 or amyloid beta42 is seen at 2-6 months of age

• these results indicate an age-dependent and selective increase in insoluble amyloid beta42 as observed in Alzheimer's patients

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:107132