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Coro1a
Gene Detail
 Symbol
Name
ID
Coro1a
coronin, actin binding protein 1A
MGI:1345961
Synonyms Clabp, coronin 1, Lmb3, p57
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.25 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:126699773-126707787 bp, - strand
From VEGA annotation of GRCm38

  8015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Coro1a

Human
homologs
Human Homolog CORO1A, coronin, actin binding protein, 1A
NCBI Gene ID 11151
neXtProt AC  NX_P31146
Human Synonyms  CLABP, CLIPINA, HCORO1, IMD8, p57, TACO
Human Chr (Location)  16p11.2; chr16:30183410-30189076 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CORO1A
Alleles
and
phenotypes
All alleles(10) : Targeted(6) Spontaneous(1) Chemically induced(1) QTL(2)
 
Mice homozygous for null or hypomorph alleles of this gene display lower peripheral T cell counts resulting from defects in T cell migration and increased rates of apoptosis.
 
Human Diseases Modeled Using Mouse Coro1a (1)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (57 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (69)    Tissues (18)    Images (25)
Theiler Stages: 10, 18, 21, 23, 24, 25, 28
Assay TypeResults
RNA in situ 55
Northern blot 12
RT-PCR 2
cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(127) Genomic(1) cDNA(125) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025099 (Evidence)
Ensembl Gene ModelENSMUSG00000030707 (Evidence)
Entrez Gene12721 (Evidence)
UniGene290482
DFCITC1573127, TC1674079
DoTSDT.101407377, DT.101407380, DT.101407387, DT.99866120, DT.99866123
NIA Mouse Gene IndexU029259
PDB2AKF, 2B4E, 2AQ5
Consensus CDS ProjectCCDS21840.1
International Mouse Knockout Project StatusCoro1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025099 VEGA Gene Model | MGI Sequence Detail 8015 C57BL/6J ±  kb
transcript OTTMUST00000061733 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000030349 VEGA | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(8) UniProt(9)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015505 Coronin
InterPro IPR027333 Coronin 1C
InterPro IPR015048 Domain of unknown function DUF1899
InterPro IPR015049 Domain of unknown function DUF1900
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000005760 coronin-1A
References (Earliest) J:141679 Yagi H, et al., Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in vivo T cell-mediated immune response. Immunol Invest. 1990 Oct-Dec;19(5-6):493-505
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(58)
Other
accession IDs
MGI:1203736, MGI:1278331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory