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Coro1a
Gene Detail
Symbol

Name
ID
Coro1a
coronin, actin binding protein 1A
MGI:1345961
Synonyms
Clabp, coronin 1, Lmb3, p57
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.25 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr7:126699773-126707787 bp, - strand
From VEGA annotation of GRCm38

  8015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Coro1a

Human
homologs
Human Homolog CORO1A, coronin, actin binding protein, 1A
NCBI Gene ID 11151
neXtProt AC  NX_P31146
Human Synonyms  CLABP, CLIPINA, HCORO1, IMD8, p57, TACO
Human Chr (Location)  16p11.2; chr16:30183410-30189076 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CORO1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) QTL(2) Spontaneous(1) Targeted(8)
Genomic Mutations involving Coro1a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null or hypomorph alleles of this gene display lower peripheral T cell counts resulting from defects in T cell migration and increased rates of apoptosis.
 
Human Diseases Modeled Using Mouse Coro1a (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Coro1a interacts with 15 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process actin cytoskeleton organization, actin filament organization, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (69)    Tissues (18)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
Northern blot 12
RT-PCR 2
cDNA source data(125)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(1) cDNA(125) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025099 (Evidence)
Ensembl Gene ModelENSMUSG00000030707 (Evidence)
Entrez Gene12721 (Evidence)
UniGene290482
DFCITC1701281, TC1674079, TC1573127
DoTSDT.101407380, DT.101407377, DT.101190052, DT.99866123, DT.99866120, DT.101407387
NIA Mouse Gene IndexU029259
PDB2AKF, 2B4E, 2AQ5
Consensus CDS ProjectCCDS21840.1
International Mouse Knockout Project StatusCoro1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025099 VEGA Gene Model | MGI Sequence Detail 8015 C57BL/6J ±  kb
transcript OTTMUST00000061733 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000030349 VEGA | MGI Sequence Detail 461 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(8) UniProt(17)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015505 Coronin
InterPro IPR015048 Domain of unknown function DUF1899
InterPro IPR015049 Domain of unknown function DUF1900
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000005760 coronin-1A
References
(Earliest) J:141679 Yagi H, et al., Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in vivo T cell-mediated immune response. Immunol Invest. 1990 Oct-Dec;19(5-6):493-505
(Latest) J:208639 Jayachandran R, et al., Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling. PLoS Biol. 2014 Mar;12(3):e1001820
All references(61)
Disease annotation references (1)
Other
accession IDs
MGI:1203736, MGI:1278331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory