Amfr
Gene Detail

Symbol Name ID

Amfr autocrine motility factor receptor MGI:1345634

Synonyms

gp78

Feature Type

protein coding gene

Genetic Map

Chromosome 8

45.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:93971588-94012663 bp, - strand From VEGA annotation of GRCm38   41076 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: conserved protein with RING finger and CUE domain, autocrine motility factor receptor type
Gene Tree: Amfr

Human homologs

Human Homolog		AMFR, autocrine motility factor receptor, E3 ubiquitin protein ligase
NCBI Gene ID		267
neXtProt AC		NX_Q9UKV5
Human Synonyms		GP78, RNF45
Human Chr (Location)		16q21; chr16:56395364-56459450 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cellular process, endoplasmic reticulum unfolded protein response, ...
Component	cytoplasm, dendrite, ...
Function	ligase activity, metal ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (86)    Tissues (40)    Images (52)
Theiler Stages: 1, 2, 3, 5, 23, 24, 28

Assay Type	Results
RNA in situ	77
RT-PCR	9

cDNA source data(208)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(213) Genomic(1) cDNA(210) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000027363 (Evidence)
Ensembl Gene Model	ENSMUSG00000031751 (Evidence)
Entrez Gene	23802 (Evidence)
UniGene	34641
DFCI	TC1572308, TC1642388, TC1781382
DoTS	DT.101345053, DT.101394998, DT.535205, DT.94228903, DT.94228908, DT.97360634
NIA Mouse Gene Index	U030114
EC	6.3.2.-
Consensus CDS Project	CCDS22533.1
International Mouse Knockout Project Status	Amfr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027363	VEGA Gene Model | MGI Sequence Detail	41076	C57BL/6J
transcript	OTTMUST00000067661	VEGA | MGI Sequence Detail	3701	Not Applicable
polypeptide	OTTMUSP00000034082	VEGA | MGI Sequence Detail	639	Not Applicable

All sequences(72) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(157 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026608	E3 ubiquitin-protein ligase AMFR
InterPro	IPR003892	Ubiquitin system component Cue
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000004568	E3 ubiquitin-protein ligase AMFR

References

(Earliest) J:56927 Shimizu K, et al., The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 1999 Aug 6;456(2):295-300
(Latest) J:186415 Fairbank M, et al., RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. FEBS Lett. 2012 Jul 30;586(16):2488-93
All references(41)