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Amfr
Gene Detail
Symbol

Name
ID
Amfr
autocrine motility factor receptor
MGI:1345634
Synonyms
gp78
Feature Type
protein coding gene
Genetic Map
Chromosome 8
45.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:93971588-94012663 bp, - strand
From VEGA annotation of GRCm38

  41076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AMFR
Protein SuperFamily: conserved protein with RING finger and CUE domain, autocrine motility factor receptor type
Gene Tree: Amfr

Human
homologs
AMFR, autocrine motility factor receptor, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 267
neXtProt AC: NX_Q9UKV5

Human Synonyms: GP78, RNF45

Human Chr (Location): 16q21; chr16:56361452-56425538 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal HMGCR turnover in mouse embryonic fibroblasts.
 
Interactions
Amfr interacts with 213 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cellular process, endoplasmic reticulum unfolded protein response, ...
Component cytoplasm, dendrite, ...
Function BAT3 complex binding, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (84)    Tissues (40)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
RT-PCR 7
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase amfr ; ZFIN amfr    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(10) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027363 (Evidence)
Ensembl Gene Model ENSMUSG00000031751 (Evidence)
Entrez Gene 23802 (Evidence)
DFCI TC1642388, TC1781382, TC1572308
DoTS DT.101394998, DT.101345053, DT.535205, DT.97360634, DT.94228903, DT.94228908
NIA Mouse Gene Index U030114
EC 6.3.2.-
Consensus CDS Project CCDS22533.1
International Mouse Phenotyping Consortium Status Amfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027363 VEGA Gene Model | MGI Sequence Detail 41076 C57BL/6J ±  kb
transcript OTTMUST00000067661 VEGA | MGI Sequence Detail 3701 Not Applicable 
polypeptide OTTMUSP00000034082 VEGA | MGI Sequence Detail 639 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(2) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(160 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003892 Ubiquitin system component Cue
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000004568 E3 ubiquitin-protein ligase AMFR
References
(Earliest) J:56927 Shimizu K, et al., The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 1999 Aug 6;456(2):295-300
(Latest) J:221247 Zhang T, et al., Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer. PLoS One. 2015;10(3):e0118448
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory