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Slc34a1
Gene Detail
Symbol

Name
ID
Slc34a1
solute carrier family 34 (sodium phosphate), member 1
MGI:1345284
Synonyms
Na/Pi cotransporter, NaPi-IIa, Npt2, renal Na+/Pi transporter, Slc17a2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
29.81 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:55399648-55414695 bp, + strand
From Ensembl annotation of GRCm38

  15048 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC34A1
Gene Tree: Slc34a1

Human
homologs
SLC34A1, solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6569
neXtProt AC: NX_Q06495

Human Synonyms: FRTS2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2

Human Chr (Location): 5q35; chr5:177384431-177398848 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLC34A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Slc34a1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit renal phosphate wasting, hyerpcalciuria, and skeletal abnormalities. Postnatal viability is reduced, putatively due to poor nutritional status.
 
Human Diseases Modeled in Mice Using Slc34a1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Slc34a1 interacts with 143 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process arsenate ion transmembrane transport, bone remodeling, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function PDZ domain binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (204)    Tissues (105)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
Western blot 7
RT-PCR 55
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN slc34a1a    NEW 
Molecular
reagents
All nucleic(28) Genomic(10) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021490 (Evidence)
Entrez Gene 20505 (Evidence)
NIA Mouse Gene Index U014886
Consensus CDS Project CCDS49271.1
International Mouse Phenotyping Consortium Status Slc34a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021490 Ensembl Gene Model | MGI Sequence Detail 15048 C57BL/6J ±  kb
transcript ENSMUST00000057167 Ensembl | MGI Sequence Detail 3081 Not Applicable 
polypeptide ENSMUSP00000059138 Ensembl | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(7) UniProt(3)
Polymorphisms
SNPs within 2kb(173 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003841 Sodium-dependent phosphate transport protein
Protein Ontology PR:000015086 sodium-dependent phosphate transport protein 2A
References
(Earliest) J:19917 Collins JF, et al., Molecular cloning, functional expression, tissue distribution, and in situ hybridization of the renal sodium phosphate (Na+/P(i)) transporter in the control and hypophosphatemic mouse. FASEB J. 1994 Aug;8(11):862-8
(Latest) J:211926 Ohata Y, et al., Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014 Jul;29(7):1627-38
All references(77)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16672, MGD-MRK-24044, MGI:103176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory