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Slc34a1
Gene Detail
 Symbol
Name
ID
Slc34a1
solute carrier family 34 (sodium phosphate), member 1
MGI:1345284
Synonyms Na/Pi cotransporter, NaPi-IIa, Npt2, renal Na+/Pi transporter, Slc17a2
Feature Type protein coding gene
Genetic Map
Chromosome 13
29.81 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:55399648-55414695 bp, + strand
From NCBI annotation of GRCm38

  15048 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc34a1

Human
homologs
Human Homolog SLC34A1, solute carrier family 34 (type II sodium/phosphate contransporter), member 1
NCBI Gene ID 6569
neXtProt AC  NX_Q06495
Human Synonyms  FRTS2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2
Human Chr (Location)  5q35; chr5:177384431-177398848 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC34A1
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Homozygous null mice exhibit renal phosphate wasting, hyerpcalciuria, and skeletal abnormalities. Postnatal viability is reduced, putatively due to poor nutritional status.
 
Human Diseases Modeled Using Mouse Slc34a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process arsenate ion transmembrane transport, bone remodeling, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function PDZ domain binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (204)    Tissues (104)    Images (29)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 142
Western blot 7
RT-PCR 55
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(10) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021490 (Evidence)
Entrez Gene20505 (Evidence)
NIA Mouse Gene IndexU014886
Consensus CDS ProjectCCDS49271.1
International Mouse Knockout Project StatusSlc34a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20505 NCBI Gene Model | MGI Sequence Detail 15048 C57BL/6J ±  kb
transcript NM_011392 RefSeq | MGI Sequence Detail 3081 C57BL/6 
polypeptide Q60825 UniProt | EBI | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(9) UniProt(3)
Polymorphisms SNPs within 2kb(173 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003841 Sodium-dependent phosphate transport protein
Protein Ontology PR:000015086 sodium-dependent phosphate transport protein 2A
Graphical View of Protein Domain Structure
References (Earliest) J:19917 Collins JF, et al., Molecular cloning, functional expression, tissue distribution, and in situ hybridization of the renal sodium phosphate (Na+/P(i)) transporter in the control and hypophosphatemic mouse. FASEB J. 1994 Aug;8(11):862-8
(Latest) J:205052 Kusaba T, et al., Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1527-32
All references(78)
Other
accession IDs
MGD-MRK-16672, MGD-MRK-24044, MGI:103176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory