Slc34a1
Gene Detail

Symbol Name ID

Slc34a1 solute carrier family 34 (sodium phosphate), member 1 MGI:1345284

Synonyms

Na/Pi cotransporter, NaPi-IIa, Npt2, renal Na+/Pi transporter, Slc17a2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

29.81 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:55399648-55414695 bp, + strand From NCBI annotation of GRCm38   15048 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc34a1

Human homologs

Human Homolog		SLC34A1, solute carrier family 34 (sodium phosphate), member 1
NCBI Gene ID		6569
neXtProt AC		NX_Q06495
Human Synonyms		FRTS2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2
Human Chr (Location)		5q35; chr5:176811432-176825849 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC34A1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice exhibit renal phosphate wasting, hyerpcalciuria, and skeletal abnormalities. Postnatal viability is reduced, putatively due to poor nutritional status.

 
Human Diseases Modeled Using Mouse Slc34a1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (36 annotations)

Process	arsenate ion transmembrane transport, bone remodeling, ...
Component	apical plasma membrane, basolateral plasma membrane, ...
Function	PDZ domain binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (162)    Tissues (65)    Images (27)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	100
Western blot	7
RT-PCR	55

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(10) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021490 (Evidence)
Entrez Gene	20505 (Evidence)
NIA Mouse Gene Index	U014886
Consensus CDS Project	CCDS49271.1
International Mouse Knockout Project Status	Slc34a1

Sequences

Length	Strain/Species
genomic	20505	NCBI Gene Model | MGI Sequence Detail	15048	C57BL/6J
transcript	NM_011392	RefSeq | MGI Sequence Detail	3081	C57BL/6
polypeptide	Q60825	UniProt | EBI | MGI Sequence Detail	637	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(147 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003841	Sodium-dependent phosphate transport protein
Protein Ontology	PR:000015086	sodium-dependent phosphate transport protein 2A

Graphical View of Protein Domain Structure

References

(Earliest) J:19917 Collins JF, et al., Molecular cloning, functional expression, tissue distribution, and in situ hybridization of the renal sodium phosphate (Na+/P(i)) transporter in the control and hypophosphatemic mouse. FASEB J. 1994 Aug;8(11):862-8
(Latest) J:193830 Boskey AL, et al., The kidney sodium-phosphate co-transporter alters bone quality in an age and gender specific manner. Bone. 2013 Apr;53(2):546-53
All references(74)

Other accession IDs

MGD-MRK-16672, MGD-MRK-24044, MGI:103176