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Slc34a1 Gene Detail
Summary
  • Symbol
    Slc34a1
  • Name
    solute carrier family 34 (sodium phosphate), member 1
  • Synonyms
    Na/Pi cotransporter, NaPi-IIa, Npt2, renal Na+/Pi transporter, Slc17a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345284
    NCBI Gene: 20505
  • Gene Overview
    MyGene.info: SLC34A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:55399622-55414695 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15074 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 29.81 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC34A1, solute carrier family 34 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC34A1, solute carrier family 34 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRTS2, HCINF2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2
  • Links
    NCBI Gene ID: 6569
    neXtProt AC: NX_Q06495
    UniProt: Q06495

  • Chr Location
    5q35.3; chr5:177384431-177412021 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc34a1 mouse models; 2 with human SLC34A1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit renal phosphate wasting, hyerpcalciuria, and skeletal abnormalities. Postnatal viability is reduced, putatively due to poor nutritional status.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20505 NCBI Gene Model | MGI Sequence Detail 15074 C57BL/6J ±  kb
    transcript NM_011392 RefSeq | MGI Sequence Detail 3081 C57BL/6  
    polypeptide Q60825 UniProt | EBI | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      172 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR003841 Sodium-dependent phosphate transport protein
      IPR029848 Sodium-dependent phosphate transport protein 2A
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 10
      cDNA 15
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16672, MGD-MRK-24044, MGI:103176
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 21
      Diseases 3
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:257428 Merametdjian L, et al., Expression of Phosphate Transporters during Dental Mineralization. J Dent Res. 2018 Feb;97(2):209-217

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory