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Tpra1 Gene Detail
Summary
  • Symbol
    Tpra1
  • Name
    transmembrane protein, adipocyte asscociated 1
  • Synonyms
    40kDa, Gpr175, Tpra40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345190
    NCBI Gene: 24100
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88879238-88889216 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.65 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345190
 protein coding gene Chr6:88879233-88889220 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031017
 protein coding gene Chr6:90318052-90328023 (+)
A/J MGP_AJ_G0030983
 protein coding gene Chr6:86850134-86860109 (+)
AKR/J MGP_AKRJ_G0030914
 protein coding gene Chr6:89326471-89336412 (+)
BALB/cJ MGP_BALBcJ_G0030996
 protein coding gene Chr6:86835652-86845624 (+)
C3H/HeJ MGP_C3HHeJ_G0030714
 protein coding gene Chr6:95102770-95112741 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031453
 protein coding gene Chr6:92736125-92746066 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028634
 protein coding gene Chr6:85000909-85011734 (+)
CAST/EiJ MGP_CASTEiJ_G0030105
 protein coding gene Chr6:89445477-89455602 (+)
CBA/J MGP_CBAJ_G0030680
 protein coding gene Chr6:96276683-96286654 (+)
DBA/2J MGP_DBA2J_G0030836
 protein coding gene Chr6:86127261-86137232 (+)
FVB/NJ MGP_FVBNJ_G0030789
 protein coding gene Chr6:85326254-85336225 (+)
LP/J MGP_LPJ_G0030913
 protein coding gene Chr6:90352635-90362606 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030822
 protein coding gene Chr6:100388386-100398357 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031480
 protein coding gene Chr6:89193221-89203196 (+)
PWK/PhJ MGP_PWKPhJ_G0029820
 protein coding gene Chr6:85109938-85119919 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029648
 protein coding gene Chr6:88005597-88015753 (+)
WSB/EiJ MGP_WSBEiJ_G0030186
 protein coding gene Chr6:89645121-89655413 (+)



Homology
more
  • Human Ortholog
    TPRA1, transmembrane protein adipocyte associated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPRA1, transmembrane protein adipocyte associated 1
  • Synonyms
    GPR175, TMEM227, TPRA40
  • Links
    NCBI Gene ID: 131601
    UniProt: Q86W33

  • Chr Location
    3q21.3; chr3:127571232-127598267 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    75
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24100 NCBI Gene Model | MGI Sequence Detail 9979 C57BL/6J ±  kb
transcript NM_011906 RefSeq | MGI Sequence Detail 1764 C57BL/6  
polypeptide Q99MU1 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    cDNA 75
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:55116 Yang H, et al., Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Endocrinology. 1999 Jun;140(6):2859-67
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory