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Tpra1 Gene Detail
Summary
  • Symbol
    Tpra1
  • Name
    transmembrane protein, adipocyte asscociated 1
  • Synonyms
    40kDa, Gpr175, Tpra40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345190
    NCBI Gene: 24100
Location & Maps
more
  • Sequence Map
    Chr6:88902251-88912238 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      9988 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.65 cM, cytoband D2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPRA1, transmembrane protein adipocyte associated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPRA1, transmembrane protein adipocyte associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPR175, TMEM227, TPRA40
  • Links
    NCBI Gene ID: 131601
    neXtProt AC: NX_Q86W33

  • Chr Location
    3q21.2; chr3:127573064-127595059 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 40799
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TPRA1
  • Gene Tree
    Tpra1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    12
  • Gene trapped
    8
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Tpra1
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    74
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024013 VEGA Gene Model | MGI Sequence Detail 9988 C57BL/6J ±  kb
transcript OTTMUST00000058695 VEGA | MGI Sequence Detail 1820 Not Applicable  
polypeptide OTTMUSP00000028483 VEGA | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000031140 transmembrane protein adipocyte-associated 1
  • InterPro Domains
    IPR018781 Transmembrane protein adipocyte-associated 1
Molecular
Reagents
less
  • All nucleic 76
    cDNA 74
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:55116 Yang H, et al., Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Endocrinology. 1999 Jun;140(6):2859-67
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory