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Pacsin1
Gene Detail
Symbol

Name
ID
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
MGI:1345181
Synonyms
A830061D09Rik, mKIAA1379, Syndapin I
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.59 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:27655509-27711106 bp, + strand
From VEGA annotation of GRCm38

  55598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22674  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: antigen EG13
Gene Tree: Pacsin1

Human
homologs
Human Homolog PACSIN1, protein kinase C and casein kinase substrate in neurons 1
NCBI Gene ID 29993
neXtProt AC  NX_Q9BY11
Human Synonyms  SDPI
Human Chr (Location)  6p21.3; chr6:34466061-34535223 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(11) Radiation induced(1)
Genomic Mutations involving Pacsin1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit reduced levels of IFN-alpha production in response to both cytosine guanine dinucleotide (CpG)-oligonucleotide (ODN) and virus.
 
Interactions
Pacsin1 interacts with 268 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process actin filament organization, cytoskeleton organization, ...
Component axon terminus, cell, ...
Function cytoskeletal protein binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (123)    Tissues (39)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(30)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021338 (Evidence)
Ensembl Gene ModelENSMUSG00000040276 (Evidence)
Entrez Gene23969 (Evidence)
UniGene4926
DFCITC1669476, TC1584999
DoTSDT.110557910, DT.91328106, DT.60105125
NIA Mouse Gene IndexU017730
PDB2X3X, 2X3V, 2X3W
Consensus CDS ProjectCCDS28567.1
International Mouse Knockout Project StatusPacsin1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021338 VEGA Gene Model | MGI Sequence Detail 55598 C57BL/6J ±  kb
transcript OTTMUST00000050598 VEGA | MGI Sequence Detail 1857 Not Applicable 
polypeptide OTTMUSP00000023644 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(617 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000012217 protein kinase C and casein kinase substrate in neurons protein 1
References
(Earliest) J:55204 Plomann M, et al., PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells. Eur J Biochem. 1998 Aug 15;256(1):201-11
(Latest) J:200757 Anggono V, et al., PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13976-81
All references(46)
Other
accession IDs
MGI:2444712

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory