Pacsin1 MGI Mouse Gene Detail - MGI:1345181 - protein kinase C and casein kinase substrate in neurons 1

Symbol

Pacsin1
Name

protein kinase C and casein kinase substrate in neurons 1
Synonyms

A830061D09Rik, mKIAA1379, Syndapin I

Feature Type

protein coding gene
IDs

MGI:1345181
NCBI Gene: 23969
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:27874565-27930092 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.59 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

608 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345181	protein coding gene	Chr17:27874483-27930456 (+)
129S1/SvImJ	ENSMUSG00200053781	protein coding gene	Chr17:23578490-23588214 (+)
A/J	ENSMUSG00195054309	protein coding gene	Chr17:24394889-24404868 (+)
AKR/J	ENSMUSG00220050060	protein coding gene	Chr17:23442530-23452507 (+)
BALB/cJ	ENSMUSG00180033430	protein coding gene	Chr17:23875366-23885089 (+)
C3H/HeJ	ENSMUSG00175050136	protein coding gene	Chr17:23431013-23440973 (+)
C57BL/6NJ	ENSMUSG00215053382	protein coding gene	Chr17:23431327-23441080 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021305	protein coding gene	Chr17:23535634-23556654 (+)
CAST/EiJ	ENSTCUG00005047789	protein coding gene	Chr17:24164234-24173943 (+)
CBA/J	ENSMUSG00210047298	protein coding gene	Chr17:23269458-23279430 (+)
DBA/2J	ENSMUSG00185051361	protein coding gene	Chr17:25483078-25494372 (+)
FVB/NJ	ENSMUSG00205027070	protein coding gene	Chr17:23745898-23755867 (+)
JF1/MsJ	ENSUMUG00000030766	protein coding gene	Chr17:24940952-24950645 (+)
LP/J	ENSMUSG00230055008	protein coding gene	Chr17:27004348-27014068 (+)
NOD/ShiLtJ	ENSMUSG00190049426	protein coding gene	Chr17:23378788-23388541 (+)
NZO/HlLtJ	ENSMUSG00225050199	protein coding gene	Chr17:28972706-28982457 (+)
PWK/PhJ	ENSLUMG00010038282	protein coding gene	Chr17:22869684-22879433 (+)
SPRET/EiJ	ENSMSPG00010047045	protein coding gene	Chr17:24162809-24172189 (+)
WSB/EiJ	ENSIUOG00005049395	protein coding gene	Chr17:24137324-24147046 (+)

Human Ortholog

PACSIN1, protein kinase C and casein kinase substrate in neurons 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PACSIN1, protein kinase C and casein kinase substrate in neurons 1
Synonyms

SDPI
Links

HGNC:8570

NCBI Gene ID: 29993

UniProt: Q9BY11
Chr Location

6p21.31; chr6:34466061-34535229 (+) GRCh38

MGI Vertebrate Homology

Pacsin1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PACSIN1
Gene Tree

Pacsin1

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

6
Gene trapped

9
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Pacsin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a gene trapped allele show altered type I interferon responses in plasmacytoid dendritic cells. Homozygotes for a null allele show impaired synaptic vesicle formation, synaptic transmission and neuronal network activity, and develop generalized seizures with tonic-clonic convulsions.

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All GO Annotations

65
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

51
cDNA Data

31
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pacsin1

ZFIN pacsin1a, pacsin1b

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All Sequences

64
RefSeq

12
UniProt

5
CCDS

CCDS28567.1

Ensembl

ENSMUSG00000040276 (Evidence)
NCBI Gene

23969

			Length	Strain/Species	Flank
genomic	23969	NCBI Gene Model \| MGI Sequence Detail	55528	C57BL/6J	± kb
transcript	NM_001286743	RefSeq \| MGI Sequence Detail	4250	C57BL/6
polypeptide	Q61644	UniProt \| EBI \| MGI Sequence Detail	441	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012217 protein kinase C and casein kinase substrate in neurons protein 1

(term hierarchy)
PDB

2X3V, 2X3W, 2X3X
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR037454 PACSIN1, F-BAR

IPR035743 PACSIN1/PACSIN2, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q61644 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 31

cDNA 31

Antibodies 3

Microarray probesets 4

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MGI:2444712

Summaries

All 70

Developmental Gene Expression 5

Gene Ontology 15

Phenotypes 21
Earliest

J:55204 Plomann M, et al., PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells. Eur J Biochem. 1998 Aug 15;256(1):201-11
Latest

J:374227 Ngo C, et al., Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections. Nat Immunol. 2025 Sep 29;

TSS for Pacsin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143349	Chr17:27874507-27874518 (+)	-52 bp
Tssr143350	Chr17:27874519-27874542 (+)	-34 bp
Tssr143351	Chr17:27874546-27874596 (+)	6 bp
Tssr143352	Chr17:27874630-27874633 (+)	67 bp
Tssr143353	Chr17:27877469-27877473 (+)	2,906 bp
Tssr143354	Chr17:27904192-27904207 (+)	29,635 bp
Tssr143355	Chr17:27904223-27904232 (+)	29,663 bp
Tssr143356	Chr17:27921496-27921499 (+)	46,933 bp
Tssr143357	Chr17:27921689-27921715 (+)	47,137 bp
Tssr143358	Chr17:27923446-27923461 (+)	48,889 bp
Tssr143359	Chr17:27923474-27923479 (+)	48,912 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24