Pacsin1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pacsin1
protein kinase C and casein kinase substrate in neurons 1
MGI:1345181

22 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pacsin1^em1(IMPC)H/Pacsin1^em1(IMPC)H C57BL/6NTac-Pacsin1^em1(IMPC)H/H	increased circulating alanine transaminase level	J:211773
Pacsin1^{Gt(OST287788)Lex}/Pacsin1^{Gt(OST287788)Lex} B6.129S5-Pacsin1^{Gt(OST287788)Lex}	abnormal plasmacytoid dendritic cell physiology	J:187784
	decreased circulating interferon-alpha level	J:187784
	decreased interferon-alpha secretion	J:187784
	normal immune system phenotype	J:187784
Pacsin1^tm1.1Bqu/Pacsin1^tm1.1Bqu Not Specified	abnormal inhibitory postsynaptic currents	J:180017
	abnormal miniature excitatory postsynaptic currents	J:180017
	abnormal nervous system electrophysiology	J:180017
	abnormal retina outer plexiform layer morphology	J:180017
	abnormal synapse morphology	J:180017
	abnormal synaptic vesicle morphology	J:180017
	abnormal synaptic vesicle number	J:180017
	abnormal synaptic vesicle recycling	J:180017
	abnormal vesicle-mediated transport	J:180017
	decreased body weight	J:180017
	decreased excitatory postsynaptic current amplitude	J:180017
	decreased miniature inhibitory postsynaptic current frequency	J:180017
	decreased synaptic depression	J:180017
	increased hippocampus volume	J:180017
	normal mortality/aging	J:180017
	reduced fertility	J:180017
	tonic-clonic seizures	J:180017

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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