About   Help   FAQ
Akt3
Gene Detail
 Symbol
Name
ID
Akt3
thymoma viral proto-oncogene 3
MGI:1345147
Synonyms D930002M15Rik, Nmf350, PKB gamma
Feature Type protein coding gene
Genetic Map
Chromosome 1
82.66 cM, cytoband H4-H6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:177020073-177258203 bp, - strand
From VEGA annotation of GRCm38

  238131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt3

Human
homologs
Human Homolog AKT3, v-akt murine thymoma viral oncogene homolog 3
NCBI Gene ID 10000
neXtProt AC  NX_Q9Y243
Human Synonyms  MPPH, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
Human Chr (Location)  1q44; chr1:243488233-243851079 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AKT3
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.
 
Interactions
Akt3 interacts with 420 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to insulin stimulus, mitochondrial genome maintenance, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (182)    Tissues (64)    Images (41)
Theiler Stages: 2, 19, 20, 21, 23, 27, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 142
Western blot 31
RT-PCR 1
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000020798 (Evidence)
Ensembl Gene ModelENSMUSG00000019699 (Evidence)
Entrez Gene23797 (Evidence)
NIA Mouse Gene IndexU022116
EC2.7.11.1
Consensus CDS ProjectCCDS35799.1
International Mouse Knockout Project StatusAkt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020798 VEGA Gene Model | MGI Sequence Detail 238131 C57BL/6J ±  kb
transcript OTTMUST00000049194 VEGA | MGI Sequence Detail 4906 Not Applicable 
polypeptide OTTMUSP00000022752 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(739 from dbSNP Build 137)    SNPs within 2kb including multiple locations(741)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003913 RAC-gamma serine/threonine-protein kinase
References (Earliest) J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
(Latest) J:209590 Li J, et al., Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation. J Clin Invest. 2014 Apr 1;124(4):1483-96
All references(87)
Other
accession IDs
MGI:2138357, MGI:3628555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory