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Akt3
Gene Detail
Symbol

Name
ID
Akt3
thymoma viral proto-oncogene 3
MGI:1345147
Synonyms
D930002M15Rik, Nmf350, PKB gamma
Feature Type
protein coding gene
Genetic Map
Chromosome 1
82.66 cM, cytoband H4-H6
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:177020073-177258203 bp, - strand
From VEGA annotation of GRCm38

  238131 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: AKT3
Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt3

Human
homologs
AKT3, v-akt murine thymoma viral oncogene homolog 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10000
neXtProt AC: NX_Q9Y243

Human Synonyms: MPPH, MPPH2, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2

Human Chr (Location): 1q44; chr1:243488233-243851079 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AKT3

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.
 
Interactions
Akt3 interacts with 419 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cellular response to insulin stimulus, mitochondrial genome maintenance, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (182)    Tissues (64)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 142
Western blot 31
RT-PCR 1
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000020798 (Evidence)
Ensembl Gene Model ENSMUSG00000019699 (Evidence)
Entrez Gene 23797 (Evidence)
NIA Mouse Gene Index U022116
EC 2.7.11.1
Consensus CDS Project CCDS35799.1
International Mouse Phenotyping Consortium Status Akt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020798 VEGA Gene Model | MGI Sequence Detail 238131 C57BL/6J ±  kb
transcript OTTMUST00000049194 VEGA | MGI Sequence Detail 4906 Not Applicable 
polypeptide OTTMUSP00000022752 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(739 from dbSNP Build 137)    SNPs within 2kb including multiple locations(741)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003913 RAC-gamma serine/threonine-protein kinase
References
(Earliest) J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
(Latest) J:218209 Phung TL, et al., Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth. Cancer Res. 2015 Jan 1;75(1):40-50
All references(90)
Other
accession IDs
MGI:2138357, MGI:3628555

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory