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Akt3 Gene Detail
Summary
  • Symbol
    Akt3
  • Name
    thymoma viral proto-oncogene 3
  • Synonyms
    D930002M15Rik, Nmf350, PKB gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345147
    NCBI Gene: 23797
  • Gene Overview
    MyGene.info: AKT3
Location & Maps
more
  • Sequence Map
    Chr1:177020073-177258203 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      238131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 82.66 cM, cytoband H4-H6
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AKT3, AKT serine/threonine kinase 3
    Orthology source: HomoloGene
  • Synonyms
    MPPH, MPPH2, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
  • Links
    NCBI Gene ID: 10000
    neXtProt AC: NX_Q9Y243

  • Chr Location
    1q44; chr1:243488233-243851079 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AKT3 associations

Human Disease Mouse Models
       Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2;   OMIM: 615937
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Targeted
    7
  • Genomic Mutations
    2 involving Akt3
  • Incidental Mutations
Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020798 VEGA Gene Model | MGI Sequence Detail 238131 C57BL/6J ±  kb
transcript OTTMUST00000049194 VEGA | MGI Sequence Detail 4906 Not Applicable  
polypeptide OTTMUSP00000022752 VEGA | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    723 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 9
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2138357, MGI:3628555
References
more
  • Summaries
    All 94
    Developmental Gene Expression 26
    Gene Ontology 8
    Phenotypes 35
  • Earliest
    J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
  • Latest
    J:231829 Wang Q, et al., Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. Cancer Cell. 2016 Apr 11;29(4):523-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory