Akt3
Gene Detail

Symbol Name ID

Akt3 thymoma viral proto-oncogene 3 MGI:1345147

Synonyms

D930002M15Rik, Nmf350, PKB gamma

Feature Type

protein coding gene

Genetic Map

Chromosome 1

82.66 cM, cytoband H4-H6
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:177020073-177258203 bp, - strand From VEGA annotation of GRCm38   238131 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55904  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RAC serine/threonine-protein kinase
Gene Tree: Akt3

Human homologs

Human Homolog		AKT3, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
NCBI Gene ID		10000
neXtProt AC		NX_Q9Y243
Human Synonyms		MPPH, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
Human Chr (Location)		1q44; chr1:243651535-244006886 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AKT3

Alleles and phenotypes

All alleles(11) : Targeted(7) Gene trapped(3) Chemically induced(1)
 

Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cellular response to insulin stimulus, mitochondrial genome maintenance, ...
Component	cytoplasm, Golgi apparatus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (178)    Tissues (61)    Images (41)
Theiler Stages: 2, 19, 20, 23, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	138
Western blot	31
RT-PCR	1

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020798 (Evidence)
Ensembl Gene Model	ENSMUSG00000019699 (Evidence)
Entrez Gene	23797 (Evidence)
NIA Mouse Gene Index	U022116
EC	2.7.11.1
Consensus CDS Project	CCDS35799.1
International Mouse Knockout Project Status	Akt3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020798	VEGA Gene Model | MGI Sequence Detail	238131	C57BL/6J
transcript	OTTMUST00000049194	VEGA | MGI Sequence Detail	4906	Not Applicable
polypeptide	OTTMUSP00000022752	VEGA | MGI Sequence Detail	479	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(578 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR017892	Protein kinase, C-terminal
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003913	RAC-gamma serine/threonine-protein kinase

References

(Earliest) J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
(Latest) J:193496 Tsiperson V, et al., Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling. J Immunol. 2013 Feb 15;190(4):1528-39
All references(81)

Other accession IDs

MGI:2138357, MGI:3628555