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Grk1
Gene Detail
 Symbol
Name
ID
Grk1
G protein-coupled receptor kinase 1
MGI:1345146
Synonyms Rhok, RK
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.93 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:13405081-13421945 bp, + strand
From Ensembl annotation of GRCm38

  16865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk1

Human
homologs
Human Homolog GRK1, G protein-coupled receptor kinase 1
NCBI Gene ID 6011
neXtProt AC  NX_Q15835
Human Synonyms  GPRK1, RHOK, RK
Human Chr (Location)  13q34
Disease Associations  (1) Diseases Associated with Human GRK1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.
 
Human Diseases Modeled Using Mouse Grk1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Grk1 interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process negative regulation of apoptotic process, phosphorylation, ...
Component membrane
Function ATP binding, G-protein coupled receptor kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (2)
Theiler Stages: 28
Assay TypeResults
RNA in situ 2
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(33)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000031450 (Evidence)
Entrez Gene24013 (Evidence)
UniGene257501
DFCITC1588231, TC1597308
DoTSDT.101158201, DT.91331468
NIA Mouse Gene IndexU009105, U173988
EC2.7.11.14
Consensus CDS ProjectCCDS22112.1
International Mouse Knockout Project StatusGrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031450 Ensembl Gene Model | MGI Sequence Detail 16865 C57BL/6J ±  kb
transcript ENSMUST00000033827 Ensembl | MGI Sequence Detail 7425 Not Applicable 
polypeptide ENSMUSP00000033827 Ensembl | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008257 rhodopsin kinase
References (Earliest) J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
(Latest) J:181424 Sakurai K, et al., Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6793-800
All references(48)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory