Grk1
Gene Detail

Symbol Name ID

Grk1 G protein-coupled receptor kinase 1 MGI:1345146

Synonyms

Rhok, RK

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.93 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:13405081-13421945 bp, + strand From Ensembl annotation of GRCm38   16865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk1

Human homologs

Human Homolog		GRK1, G protein-coupled receptor kinase 1
NCBI Gene ID		6011
neXtProt AC		NX_Q15835
Human Synonyms		GPRK1, RHOK, RK
Human Chr (Location)		13q34
Disease Associations		(1) Diseases Associated with Human GRK1

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.

 
Human Diseases Modeled Using Mouse Grk1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	negative regulation of apoptotic process, phosphorylation, ...
Component	membrane
Function	ATP binding, G-protein coupled receptor kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (2)
Theiler Stages: 28

Assay Type	Results
RNA in situ	2

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(1) cDNA(32)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000031450 (Evidence)
Entrez Gene	24013 (Evidence)
UniGene	257501
DFCI	TC1588231, TC1597308
DoTS	DT.101158201, DT.91331468
NIA Mouse Gene Index	U009105, U173988
EC	2.7.11.14
Consensus CDS Project	CCDS22112.1
International Mouse Knockout Project Status	Grk1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031450	Ensembl Gene Model | MGI Sequence Detail	16865	C57BL/6J
transcript	ENSMUST00000033827	Ensembl | MGI Sequence Detail	7425	Not Applicable
polypeptide	ENSMUSP00000033827	Ensembl | MGI Sequence Detail	564	Not Applicable

All sequences(20) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR000239	GPCR kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008257	rhodopsin kinase

References

(Earliest) J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
(Latest) J:181424 Sakurai K, et al., Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6793-800
All references(48)