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Grk1
Gene Detail
Symbol

Name
ID
Grk1
G protein-coupled receptor kinase 1
MGI:1345146
Synonyms
Rhok, RK
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.93 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:13405081-13421945 bp, + strand
From Ensembl annotation of GRCm38

  16865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRK1
Protein SuperFamily: G protein-coupled receptor kinase
Gene Tree: Grk1

Human
homologs
GRK1, G protein-coupled receptor kinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6011
neXtProt AC: NX_Q15835

Human Synonyms: GPRK1, RHOK, RK

Human Chr (Location): 13q34

Disease Associations: (1) Diseases Associated with Human GRK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.
 
Human Diseases Modeled in Mice Using Grk1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Grk1 interacts with 443 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process negative regulation of apoptotic process, phosphorylation, ...
Component membrane, photoreceptor outer segment
Function ATP binding, G-protein coupled receptor kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(1) cDNA(33)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000031450 (Evidence)
Entrez Gene 24013 (Evidence)
UniGene 257501
DFCI TC1588231, TC1597308
DoTS DT.101158201, DT.91331468
NIA Mouse Gene Index U009105, U173988
EC 2.7.11.14
Consensus CDS Project CCDS22112.1
International Mouse Phenotyping Consortium Status Grk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031450 Ensembl Gene Model | MGI Sequence Detail 16865 C57BL/6J ±  kb
transcript ENSMUST00000033827 Ensembl | MGI Sequence Detail 7425 Not Applicable 
polypeptide ENSMUSP00000033827 Ensembl | MGI Sequence Detail 564 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(259 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000239 GPCR kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR016137 RGS domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008257 rhodopsin kinase
References
(Earliest) J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
(Latest) J:221472 Azevedo AW, et al., C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife. 2015;4
All references(48)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory