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Targeted Allele Detail
Symbol: Grk1tm1Citb
Name: G protein-coupled receptor kinase 1; targeted mutation 1, California Institute of Technology - Biology
MGI ID: MGI:2668595
Synonyms: GRK -, Grk1tm1Mis, RK-
Gene: Grk1  Location: Chr8:13455081-13471951 bp, + strand  Genetic Position: Chr8, 5.93 cM, cytoband A2
Alliance: Grk1tm1Citb page
Altered morphology of Grk1tm1Citb/Grk1tm1Citb retina

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:54021
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected in the retinas of homozygous mutant mice by Western blot analysis. (J:54021)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk1 Mutation:  32 strains or lines available
Original:  J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory