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| Caption | A: Morphology of the central retina of cyclic light reared and dark reared mouse retinas at 6 weeks of age. (1) Wild type, raised in cyclic illumination (50 lux). (2) Grk1tm1Citb/Grk1+, raised in cyclic illumination (50 lux). (3) Grk1tm1Citb/Grk1tm1Citb, born and raised in the dark. (4) Homozygous mutant reared in cyclic illumination (50 lux). The outer segments in 4 lacked the characteristic orderly arrangement seen in 1, 2 and 3 and were approximately 50% shorter. (Scale bar 16um). B: Light induced photoreceptor apoptosis of dark reared mutant mice after 24 hours in continuous room light (450 lux). (Upper) Results of TUNEL staining photographed in the presence of dim background light. Positive nuclei were in the outer nuclear layer. (Scale bar 100um). (Lower) Corrresponding morphological changes shown in upper (scale bar 16um). | ||||
| Copyright | This image is from Chen CK, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3718-22. Copyright 1999 National Academy of Sciences, U.S.A. J:54021 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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