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Spry4
Gene Detail
Symbol

Name
ID
Spry4
sprouty homolog 4 (Drosophila)
MGI:1345144
Synonyms
A030006O18Rik, sprouty4
Feature Type
protein coding gene
Genetic Map
Chromosome 18
20.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:38586268-38601268 bp, - strand
From Ensembl annotation of GRCm38

  15001 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPRY4
Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry4

Human
homologs
SPRY4, sprouty RTK signaling antagonist 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 81848
neXtProt AC: NX_Q9C004

Human Synonyms: HH17

Human Chr (Location): 5q31.3; chr5:142310427-142325055 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SPRY4

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(47) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for two alleles of this locus display in limb deformation. Mice homozygous for a different allele display partial penetrance of diastema tooth formation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Spry4 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process multicellular organismal development, negative regulation of ERK1 and ERK2 cascade, ...
Component cytoplasm, focal adhesion, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (331)    Tissues (117)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 317
Northern blot 5
Western blot 3
RT-PCR 6
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SPRY4 ; Xenbase spry4 ; ZFIN spry4    NEW 
Molecular
reagents
All nucleic(37) cDNA(33) Primer pair(2) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024427 (Evidence)
Entrez Gene 24066 (Evidence)
UniGene 42038
DFCI TC1605588, TC1766923, TC1582732
DoTS DT.40139046, DT.97359857
NIA Mouse Gene Index U038361
Consensus CDS Project CCDS29202.1
International Mouse Phenotyping Consortium Status Spry4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024427 Ensembl Gene Model | MGI Sequence Detail 15001 C57BL/6J ±  kb
transcript ENSMUST00000025295 Ensembl | MGI Sequence Detail 4587 Not Applicable 
polypeptide ENSMUSP00000025295 Ensembl | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015585 protein sprouty homolog 4
References
(Earliest) J:54185 de Maximy AA, et al., Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999 Mar;81(1-2):213-6
(Latest) J:221443 Goldshmit Y, et al., Decreased anti-regenerative effects after spinal cord injury in spry4-/- mice. Neuroscience. 2015 Feb 26;287:104-12
All references(102)
Other
accession IDs
MGI:2444550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory