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Spry4 Gene Detail
Summary
  • Symbol
    Spry4
  • Name
    sprouty RTK signaling antagonist 4
  • Synonyms
    A030006O18Rik, sprouty4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345144
    NCBI Gene: 24066
  • Gene Overview
    MyGene.info: SPRY4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:38586268-38601268 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15001 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 20.50 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SPRY4, sprouty RTK signaling antagonist 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SPRY4, sprouty RTK signaling antagonist 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH17
  • Links
    NCBI Gene ID: 81848
    neXtProt AC: NX_Q9C004
    UniProt: Q9C004

  • Chr Location
    5q31.3; chr5:142310427-142325055 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human SPRY4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for two alleles of this locus display in limb deformation. Mice homozygous for a different allele display partial penetrance of diastema tooth formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024427 Ensembl Gene Model | MGI Sequence Detail 15001 C57BL/6J ±  kb
    transcript ENSMUST00000025295 Ensembl | MGI Sequence Detail 4587 Not Applicable  
    polypeptide ENSMUSP00000025295 Ensembl | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      107 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 34
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2444550
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 72
      Diseases 1
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:54185 de Maximy AA, et al., Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999 Mar;81(1-2):213-6
    • Latest
      J:264612 Morgani SM, et al., A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev Biol. 2018 Sep 1;441(1):104-126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory