Spry4
Gene Detail

Symbol Name ID

Spry4 sprouty homolog 4 (Drosophila) MGI:1345144

Synonyms

A030006O18Rik, sprouty4

Feature Type

protein coding gene

Genetic Map

Chromosome 18

20.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:38586268-38601268 bp, - strand From Ensembl annotation of GRCm38   15001 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry4

Human homologs

Human Homolog		SPRY4, sprouty homolog 4 (Drosophila)
NCBI Gene ID		81848
neXtProt AC		NX_Q9C004
Human Chr (Location)		5q31.3; chr5:141689992-141704620 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(52) : Targeted(5) Gene trapped(47)
 

Mice homozygous for two alleles of this locus display in limb deformation. Mice homozygous for a different allele display partial penetrance of diastema tooth formation.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	multicellular organismal development, negative regulation of MAP kinase activity, ...
Component	cytoplasm, membrane
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (329)    Tissues (117)    Images (60)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	317
Northern blot	5
Western blot	3
RT-PCR	4

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) cDNA(33) Primer pair(1) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024427 (Evidence)
Entrez Gene	24066 (Evidence)
UniGene	42038
DFCI	TC1582732, TC1605588, TC1766923
DoTS	DT.40139046, DT.97359857
NIA Mouse Gene Index	U038361
Consensus CDS Project	CCDS29202.1
International Mouse Knockout Project Status	Spry4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024427	Ensembl Gene Model | MGI Sequence Detail	15001	C57BL/6J
transcript	ENSMUST00000025295	Ensembl | MGI Sequence Detail	4587	Not Applicable
polypeptide	ENSMUSP00000025295	Ensembl | MGI Sequence Detail	300	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007875	Sprouty
Protein Ontology	PR:000015585	protein sprouty 4

References

(Earliest) J:54185 de Maximy AA, et al., Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999 Mar;81(1-2):213-6
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(89)

Other accession IDs

MGI:2444550