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Spry4
Gene Detail
 Symbol
Name
ID
Spry4
sprouty homolog 4 (Drosophila)
MGI:1345144
Synonyms A030006O18Rik, sprouty4
Feature Type protein coding gene
Genetic Map
Chromosome 18
20.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:38586268-38601268 bp, - strand
From Ensembl annotation of GRCm38

  15001 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: sprouty homolog protein
Gene Tree: Spry4

Human
homologs
Human Homolog SPRY4, sprouty homolog 4 (Drosophila)
NCBI Gene ID 81848
neXtProt AC  NX_Q9C004
Human Synonyms  HH17
Human Chr (Location)  5q31.3; chr5:142310427-142325055 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SPRY4
Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(47) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for two alleles of this locus display in limb deformation. Mice homozygous for a different allele display partial penetrance of diastema tooth formation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Spry4 interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process multicellular organismal development, negative regulation of MAP kinase activity, ...
Component cytoplasm, Golgi apparatus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (329)    Tissues (117)    Images (60)
Theiler Stages: 11, 12, 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 317
Northern blot 5
Western blot 3
RT-PCR 4
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(33) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024427 (Evidence)
Entrez Gene24066 (Evidence)
UniGene42038
DFCITC1582732, TC1605588, TC1766923
DoTSDT.40139046, DT.97359857
NIA Mouse Gene IndexU038361
Consensus CDS ProjectCCDS29202.1
International Mouse Knockout Project StatusSpry4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024427 Ensembl Gene Model | MGI Sequence Detail 15001 C57BL/6J ±  kb
transcript ENSMUST00000025295 Ensembl | MGI Sequence Detail 4587 Not Applicable 
polypeptide ENSMUSP00000025295 Ensembl | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007875 Sprouty
Protein Ontology PR:000015585 protein sprouty homolog 4
References (Earliest) J:54185 de Maximy AA, et al., Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo. Mech Dev. 1999 Mar;81(1-2):213-6
(Latest) J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
All references(94)
Other
accession IDs
MGI:2444550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory