Spry4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spry4
sprouty RTK signaling antagonist 4
MGI:1345144

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Spry2^tm1.1Mrt/Spry2⁺ Spry4^tm1.2Mrt/Spry4^tm1.2Mrt involves: 129P2/OlaHsd	abnormal autopod morphology	J:315670
	abnormal chondrocyte morphology	J:315670
	abnormal primary cilium morphology	J:315670
	abnormal skeleton morphology	J:315670
	increased enchondroma incidence	J:315670
	increased osteochondroma incidence	J:315670
	short tibia	J:315670
Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Spry4^tm1.2Mrt/Spry4⁺ involves: 129P2/OlaHsd	abnormal autopod morphology	J:315670
	abnormal skeleton morphology	J:315670
	increased enchondroma incidence	J:315670
	increased osteochondroma incidence	J:315670
Spry2^tm1Ayos/Spry2⁺ Spry4^tm1Ayos/Spry4^tm1Ayos involves: 129 * C57BL/6J	decreased body weight	J:116506
	perinatal lethality, incomplete penetrance	J:116506
	postnatal lethality, incomplete penetrance	J:116506
Spry2^tm1Ayos/Spry2^tm1Ayos Spry4^tm1Ayos/Spry4⁺ involves: 129 * C57BL/6J	prenatal lethality, complete penetrance	J:116506
Spry2^tm1Ayos/Spry2^tm1Ayos Spry4^tm1Ayos/Spry4^tm1Ayos involves: 129 * C57BL/6J	abnormal brain development	J:116506
	abnormal craniofacial morphology	J:116506
	abnormal forebrain development	J:116506
	abnormal limb morphology	J:116506
	abnormal lung development	J:116506
	abnormal respiratory conducting tube morphology	J:116506
	alobar holoprosencephaly	J:116506
	cyclopia	J:116506
	embryonic lethality during organogenesis, incomplete penetrance	J:116506
	prenatal lethality, complete penetrance	J:116506

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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