Spry4^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Spry4^tm1Ayos
• Name: sprouty RTK signaling antagonist 4; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3699499
• Gene: Spry4 Location: Chr18:38719300-38734400 bp, - strand Genetic Position: Chr18, 20.5 cM
• Alliance: Spry4^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116506
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin resistance cassette. Western blot confirmed absence of protein in mutants. (J:116506)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry4 Mutation: 43 strains or lines available

References

• Original: J:116506 Taniguchi K, et al., Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun. 2007 Jan 26;352(4):896-902
• All: 4 reference(s)