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Sigirr
Gene Detail
Symbol

Name
ID
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
MGI:1344402
Synonyms
Sigirr, Tir8
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:141091175-141100546 bp, - strand
From Ensembl annotation of GRCm38

  9372 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SIGIRR
Gene Tree: Sigirr

Human
homologs
SIGIRR, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 59307
neXtProt AC: NX_Q6IA17

Human Synonyms: TIR8

Human Chr (Location): 11p15.5; chr11:405716-417454 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
When challenged, homozygous mutant mice show an increased inflammatory response.
 
Interactions
Sigirr interacts with 19 markers (Mir10a, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process acute-phase response, negative regulation of chemokine biosynthetic process, ...
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (33)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sigirr ; ZFIN sigirr    NEW 
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000025494 (Evidence)
Entrez Gene 24058 (Evidence)
UniGene 38017
DFCI TC1582320, TC1588971
DoTS DT.101123488, DT.529522, DT.111018711, DT.94261937, DT.97356103
NIA Mouse Gene Index U138838
Consensus CDS Project CCDS40179.1
International Mouse Phenotyping Consortium Status Sigirr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025494 Ensembl Gene Model | MGI Sequence Detail 9372 C57BL/6J ±  kb
transcript ENSMUST00000097958 Ensembl | MGI Sequence Detail 1990 Not Applicable 
polypeptide ENSMUSP00000095571 Ensembl | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000014863 single Ig IL-1-related receptor
References
(Earliest) J:55824 Thomassen E, et al., Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 1999 Jun;11(6):389-99
(Latest) J:205900 Russell SE, et al., Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by gammadelta T cells. J Immunol. 2013 Sep 15;191(6):3337-46
All references(57)
Other
accession IDs
MGI:2141892

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory