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Sigirr Gene Detail
Summary
  • Symbol
    Sigirr
  • Name
    single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  • Synonyms
    Sigirr, Tir8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344402
    NCBI Gene: 24058
  • Gene Overview
    MyGene.info: SIGIRR
Location & Maps
more
  • Sequence Map
    Chr7:141091175-141100572 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9398 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.35 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SIGIRR, single Ig and TIR domain containing
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIGIRR, single Ig and TIR domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-1R8, TIR8
  • Links
    NCBI Gene ID: 59307
    neXtProt AC: NX_Q6IA17

  • Chr Location
    11p15.5; chr11:405716-417454 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    8
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Sigirr
  • Incidental Mutations
When challenged, homozygous mutant mice show an increased inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060386 VEGA Gene Model | MGI Sequence Detail 9398 C57BL/6J ±  kb
transcript OTTMUST00000147760 VEGA | MGI Sequence Detail 1990 Not Applicable  
polypeptide OTTMUSP00000076869 VEGA | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014863 single Ig IL-1-related receptor
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR015621 Interleukin-1 receptor family
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Molecular
Reagents
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  • All nucleic 36
    cDNA 36

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141892
References
more
  • Summaries
    All 57
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 33
  • Earliest
    J:55824 Thomassen E, et al., Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 1999 Jun;11(6):389-99
  • Latest
    J:231648 Nold-Petry CA, et al., IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 2015 Apr;16(4):354-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory