Sigirr Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
MGI:1344402

9 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sigirr^tm1Lix/Sigirr^tm1Lix involves: 129S6/SvEvTac * BALB/c	abnormal chemokine secretion	J:85151
	abnormal splenocyte proliferation	J:85151
	increased inflammatory response	J:85151
	increased susceptibility to endotoxin shock	J:85151
Sigirr^tm1Mant/Sigirr^tm1Mant involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal chemokine secretion	J:88907
	abnormal dendritic cell physiology	J:88907
	abnormal interleukin secretion	J:88907
	normal immune system phenotype	J:88907
	increased interleukin-6 secretion	J:88907
	increased susceptibility to induced colitis	J:88907

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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